Results 1 to 10 of about 20,897 (221)

Heparan Sulfate Proteoglycans in Tauopathy [PDF]

Biomolecules, 2022
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Yanan Zhu, Lauren Gandy, Fuming Zhang, Jian Liu, Chunyu Wang, Laura J. Blair, Robert J. Linhardt, Lianchun Wang   +7 more
doaj   +4 more sources

Heparan Sulfate Proteoglycans in Human Colorectal Cancer [PDF]

Analytical Cellular Pathology, 2018
Colorectal cancer is the third most common cancer worldwide, accounting for more than 610,000 mortalities every year. Prognosis of patients is highly dependent on the disease stage at diagnosis.
Carolina Meloni Vicente, Daiana Aparecida da Silva, Priscila Veronica Sartorio, Tiago Donizetti Silva, Sarhan Sydney Saad, Helena Bonciani Nader, Nora Manoukian Forones, Leny Toma   +7 more
doaj   +4 more sources

Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression [PDF]

Frontiers in Endocrinology, 2018
Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains. Proteins with covalently bound Heparan sulfate chains are termed Heparan Sulfate
Arvindhan Nagarajan, Parmanand Malvi, Narendra Wajapeyee, Narendra Wajapeyee   +3 more
doaj   +4 more sources

A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors [PDF]

Frontiers in Immunology, 2021
While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell receptors with non-conventional ligands, particularly carbohydrate antigens, is less well ...
Klara Klein, Klara Klein, Klara Klein, Angelique Hölzemer, Angelique Hölzemer, Angelique Hölzemer, Tim Wang, Tim Wang, Tim Wang, Tae-Eun Kim, Haley L. Dugan, Haley L. Dugan, Stephanie Jost, Stephanie Jost, Marcus Altfeld, Wilfredo F. Garcia-Beltran, Wilfredo F. Garcia-Beltran   +16 more
doaj   +2 more sources

Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis.

Blood
Abstract From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology.
Piszczatowski RT, Bülow HE, Steidl U.
europepmc   +3 more sources

Profiling Heparan Sulfate Proteoglycans in Ovarian Carcinoma [PDF]

The Scientific World Journal, 2005
: heparan sulfate, proteoglycans, syndecan, glypican, perlecan, ovarian carcinoma, angiogenesis, prognostic factors Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed cell surface and extracellular matrix (ECM) molecules consisting of a core protein covalently attached to the structurally complex glycosaminoglycan, heparan sulfate (HS ...
Andrew R. Clamp, Gordon C. Jayson
doaj   +5 more sources

Heparan Sulfate Proteoglycans: Key Mediators of Stem Cell Function [PDF]

Frontiers in Cell and Developmental Biology, 2020
Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of glycoproteins with exquisite structural complexity. They are ubiquitously expressed across tissues and have been found to exert a multitude of effects on cell behavior and ...
Maanasa Ravikumar, Maanasa Ravikumar, Raymond Alexander Alfred Smith, Victor Nurcombe, Victor Nurcombe, Simon M. Cool, Simon M. Cool   +6 more
doaj   +2 more sources

Heparan Sulfate Proteoglycans as Relays of Neuroinflammation. [PDF]

J Histochem Cytochem, 2018
Heparan sulfate proteoglycans (HSPGs) are implicated as inflammatory mediators in a variety of settings, including chemokine activation, which is required to recruit circulating leukocytes to infection sites. Heparan sulfate (HS) polysaccharide chains are highly interactive and serve co-receptor roles in multiple ligand:receptor interactions.
O'Callaghan P, Zhang X, Li JP.
europepmc   +5 more sources

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling [PDF]

eLife, 2020
R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4,
Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi   +12 more
doaj   +2 more sources

Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity [PDF]

Frontiers in Molecular Neuroscience, 2018
Neural circuits consist of distinct neuronal cell types connected in specific patterns. The specificity of these connections is achieved in a series of sequential developmental steps that involve the targeting of neurites, the identification of synaptic ...
Giuseppe Condomitti, Giuseppe Condomitti, Joris de Wit, Joris de Wit   +3 more
doaj   +4 more sources