Heparan Sulfate Proteoglycans in Tauopathy [PDF]
Biomolecules, 2022 Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Yanan Zhu +7 more
doaj +5 more sources
Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression [PDF]
Frontiers in Endocrinology, 2018 Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains. Proteins with covalently bound Heparan sulfate chains are termed Heparan Sulfate
Arvindhan Nagarajan +3 more
doaj +4 more sources
Heparan Sulfate Proteoglycans in Human Colorectal Cancer [PDF]
Analytical Cellular Pathology, 2018 Colorectal cancer is the third most common cancer worldwide, accounting for more than 610,000 mortalities every year. Prognosis of patients is highly dependent on the disease stage at diagnosis.
Carolina Meloni Vicente +7 more
doaj +4 more sources
Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type [PDF]
Scientific Reports, 2017 Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Elisabet Ihse +5 more
doaj +3 more sources
Effect of epithelial debridement on human cornea proteoglycans [PDF]
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
doaj +2 more sources
Heparan sulfate proteoglycans: structure, protein interactions and cell signaling [PDF]
Anais da Academia Brasileira de Ciências, 2009 Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular matrix in all the animal species. This review will focus on the structural characteristics of the heparan sulfate proteoglycans related to protein interactions ...
Juliana L. Dreyfuss +5 more
doaj +4 more sources
A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors [PDF]
Frontiers in Immunology, 2021 While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell receptors with non-conventional ligands, particularly carbohydrate antigens, is less well ...
Klara Klein +16 more
doaj +2 more sources
Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling [PDF]
Brazilian Journal of Medical and Biological Research, 2006 The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a
C.C. Lopes, C.P. Dietrich, H.B. Nader
doaj +3 more sources
Importance of Heparan Sulfate Proteoglycans in Pancreatic Islets and β-Cells. [PDF]
Int J Mol Sci, 2022 Takahashi I.
europepmc +3 more sources
An Atlas of Heparan Sulfate Proteoglycans in the Postnatal Rat Lens. [PDF]
Invest Ophthalmol Vis Sci, 2021 Wishart TFL, Lovicu FJ.
europepmc +2 more sources