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Structural Properties of the Heparan Sulfate Proteoglycans of Brain
Journal of Neurochemistry, 1989Abstract: The heparan sulfate proteoglycans present in a deoxycholate extract of rat brain were purified by ion exchange chromatography, affinity chromatography on lipoprotein lipase agarose, and gel filtration. Heparitinase treatment of the heparan sulfate proteoglycan fraction (containing 86% heparan sulfate and 10% chondroitin sulfate) that was ...
Richard U. Margolis, James A. Ripellino
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Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans [PDF]
Glycobiology, 2001 Heparanases are endoglycosidases that cleave the heparan sulfate glycosaminoglycans from proteoglycan core proteins and degrade them to small oligosaccharides. Inside cells, these enzymes are important for the normal catabolism of heparan sulfate proteoglycans (HSPGs), generating glycosaminoglycan fragments that are then transported to lysosomes and ...
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Heparan sulfate proteoglycans in healthy and diseased systems
WIREs Systems Biology and Medicine, 2011AbstractHeparin and heparan sulfate (HS) are glycosaminoglycans (GAGs) that are synthesized in the tissues and organs of mammals. They are synthesized and attached to a core protein as proteoglycans through serine–glycine concensus motifs along the core protein.
John M. Whitelock, James Melrose
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Synthesis of heparan sulfate proteoglycans by the isolated glomerulus
Biochemistry and Cell Biology, 1988Incorporation of [35S]sulfate into newly synthesized macromolecules was studied in the isolated rat glomerulus and found to be linear between 6 and 24 h. When whole glomeruli were treated under conditions that dissociate proteoglycan aggregates, >90% of incorporated label was extracted.
Marina Khatchatourian +1 more
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Heparan Sulfate Proteoglycan-Mediated Polyamine Uptake
2011The polyamines are polycationic compounds essential for cellular proliferation and transformation. In addition to a well-defined biosynthesis pathway, polyamines are internalized into cells by as yet incompletely defined mechanisms. Numerous reports have shown that efficient polyamine uptake depends on the presence of polyanionic, cell surface ...
Paulina Kucharzewska +3 more
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Functions of Cell Surface Heparan Sulfate Proteoglycans
Annual Review of Biochemistry, 1999▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a large number of extracellular ligands. Members of both cell surface heparan sulfate proteoglycan families, the transmembrane syndecans and the glycosylphosphoinositide-linked glypicans, bind these ligands and enhance formation of their receptor-signaling ...
Masahiro Zako +6 more
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Heparan sulfate proteoglycans and the emergence of neuronal connectivity
Current Opinion in Neurobiology, 2006With the identification of the molecular determinants of neuronal connectivity, our understanding of the extracellular information that controls axon guidance and synapse formation has evolved from single factors towards the complexity that neurons face in a living organism.
David Van Vactor +2 more
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Heparan sulfate proteoglycans in Drosophila neuromuscular development
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017Heparan sulfate proteoglycans (HSPGs) are glycoconjugates bearing heparan sulfate (HS) chains covalently attached to core proteins, which are ubiquitously distributed on the cell surface and in the extracellular matrix. HSPGs interact with a number of molecules mainly through HS chains, which play critical roles in diverse physiological and disease ...
Nobuaki Maeda, Keisuke Kamimura
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Disulfide-bonded aggregates of heparan sulfate proteoglycans
Biochemistry, 1984Heparan sulfate proteoglycans have been isolated from Swiss mouse 3T3 cells by using two nondegradative techniques: extraction with 4 M guanidine or 2.5% 1-butanol. These proteoglycans were separated from copurifying chondroitin sulfate proteoglycans by using ion-exchange chromatography on DEAE-cellulose in the presence of 2 M urea.
Linda J. Lowe-Krentz, John M. Keller
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Functions of Heparan Sulfate Proteoglycans in Morphogenesis
2009Heparan sulfate proteoglycans (HSPG) are present ubiquitously on the cell surface and in the extracellular matrix including the basement membranes. There are two families of HSPGs in the cell surface, syndecans and glypicans. HSPGs in the extracellular matrix are mainly perlecan and agrin.
Hiroko Habuchi, Koji Kimata
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