Results 161 to 170 of about 40,174 (273)

Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin

open access: yesViruses
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells.
Jiyuan Yang   +12 more
doaj   +1 more source

Mineralized Collagen: Adaptation of the Mineral Content to Control BMP‐2 Delivery

open access: yesJournal of Biomedical Materials Research Part A, Volume 114, Issue 1, January 2026.
ABSTRACT To achieve bone regeneration in critical size defects, filling of the defect either with autologous bone or with a biodegradable bone substitute material possessing osteoconductivity and osteoinductivity is required. Biomimetically mineralized collagen is a nanocomposite material that closely resembles the natural bone matrix in composition ...
Leonie Schlicht   +5 more
wiley   +1 more source

Profiling of Extracellular Vesicles of Non‐Small Cell Lung Cancer Reveals Proteins Associated With Osimertinib Resistance

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Non‐invasive biomarkers are needed to further personalize EGFR tyrosine kinase inhibitor (EGFR TKI) osimertinib treatment in non‐small cell lung cancer (NSCLC) patients. By analysing the proteome of extracellular vesicles (EVs) isolated from an osimertinib resistant NSCLC cell line and from serum of patients given osimertinib in second line within the ...
Albano Cáceres‐Verschae   +15 more
wiley   +1 more source

Oral Delivery of R‐spondin1‐Loaded Small Extracellular Vesicles Activates WNT Signalling Pathway to Accelerate Intestinal Injury Repair and Reverse Ageing

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Yang et al. demonstrated that HSPG mediate the loading of active R‐spondin1 protein onto the surface of small extracellular vesicles (evRSPO1). evRSPO1 induced WNT/β‐catenin activity in intestinal organoids and tissues, thereby regulating intestinal stem cells proliferation.
Lingyan Yang   +13 more
wiley   +1 more source

Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans. [PDF]

open access: yesEMBO J, 2021
Bermejo-Jambrina M   +14 more
europepmc   +1 more source

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