Results 171 to 180 of about 40,174 (273)

CDG due to Defective Membrane Transporters: Update

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Congenital disorders of glycosylation are genetic defects in the glycoprotein and glycolipid glycan assembly and attachment. Some 200 CDG have been reported since the first clinical description in 1980. Most CDG are enzymatic deficiencies, but 13 (6.5%) are defects in the ER, Golgi apparatus (GA), and plasma membrane transporters.
D. Quelhas, C. R. Ferreira, J. Jaeken
wiley   +1 more source

Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson's in vivo models. [PDF]

Life Sci Alliance, 2022
Chen M, Vincent J, Ezeanii A, Wakade S, Yerigenahally S, Mor DE.   +5 more
europepmc   +1 more source

The Low Density Lipoprotein Receptor-related Protein Complexes with Cell Surface Heparan Sulfate Proteoglycans to Regulate Proteoglycan-mediated Lipoprotein Catabolism

, 2003
Larissa Wilsie, Robert A. Orlando
openalex   +1 more source

Mastering Organoid Growth: A Complete Guide to Overcoming Methodological Challenges

MedComm, Volume 7, Issue 1, January 2026.
Organoids offer transformative 3D models that precisely mimic human organ architecture and function. This review details the latest methodology, emphasizing the cultivation of liver and other abdominal organoids. We analyze technological challenges (e.g., nutrient delivery, scalability, diversity) and provide practical insights for new researchers ...
Chunbao Jiao, Omer Faruk Karakaya, Neda Dadgar, Chase J. Wehrle, Zahra Massoud, Hanna Hong, Robert L. Fairchild, Nic Leipzig, Federico Aucejo, Wen Wee Ma, Jan Joseph Melenhorst, Sofia Ferreira Gonzales, Andrea Schlegel   +12 more
wiley   +1 more source

Pericellular heparan sulfate proteoglycans: Role in regulating the biosynthetic response of nucleus pulposus cells to osmotic loading. [PDF]

JOR Spine, 2022
Krull CM, Rife J, Klamer B, Purmessur D, Walter BA.   +4 more
europepmc   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Heparan Sulfate Proteoglycans Mediate Attachment and Entry of Human T-Cell Leukemia Virus Type 1 Virions into CD4 ⁺ T Cells

, 2005
Kathryn S. Jones, Cari Petrow‐Sadowski, Daniel Bertolette, Ying Huang, Francis W. Ruscetti   +4 more
openalex   +1 more source

MMP2 Sheds Glypican‐4 to Suppress Slit3‐Robo4 Signaling and Angiogenesis

Proteoglycan Research, Volume 4, Issue 1, January 2026.
ABSTRACT Axon guidance molecules, initially identified for their roles in neural development, are now recognized as crucial regulators of angiogenesis and blood vessel patterning. Among these, Slit3 promotes endothelial cell migration, proliferation, and vascular network formation by signaling through the endothelial‐specific receptor Robo4.
Wenyuan Xiao, Alexander R. Orta, Jingwen Yue, Xuehong Song, Huquan Yin, Lianchun Wang   +5 more
wiley   +1 more source

Heparan sulfate proteoglycans serve as alternative receptors for low affinity LCMV variants. [PDF]

PLoS Pathog, 2021
Volland A, Lohmüller M, Heilmann E, Kimpel J, Herzog S, von Laer D.   +5 more
europepmc   +1 more source

Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease [PDF]

, 1991
George Perry, SL Siedlak, Peggy L. Richey, Mitsuru Kawai, Patrick Cras, RN Kalaria, Galloway Pg, J. Marian Scardina, Barbara Cordell, BD Greenberg   +9 more
openalex   +1 more source