Results 11 to 20 of about 17,555 (155)
Heparan Sulfate Proteoglycans in Tauopathy. [PDF]
Biomolecules, 2022 Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis. Heparan sulfate proteoglycans, a major type of extracellular matrix, have been believed to involve in tauopathies.
Zhu Y +7 more
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Heparan Sulfate Proteoglycans [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Jeffrey D. Esko +2 more
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Heparan sulfate proteoglycans and cancer [PDF]
British Journal of Cancer, 2001 Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached.
Blackhall, F. H. +3 more
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Heparan sulfate proteoglycans at a glance [PDF]
Journal of Cell Science, 2007 Proteoglycans are abundant components of the cell surface and extracellular matrix that mediate critical interactions between cells and their environment. They play a variety of biological roles in normal tissues and in response to injury and disease.
Scott B. Selleck, Catherine Kirkpatrick
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Agrin Is a Heparan Sulfate Proteoglycan [PDF]
Journal of Biological Chemistry, 1995 In the present study we have identified the extracellular matrix protein agrin as a major heparan sulfate proteoglycan (HSPG) in embryonic chick brain. Using monoclonal antibodies and a polyclonal antiserum to the core protein of a previously identified HSPG from embryonic chick brain, our expression screened a random-primed E9 chick brain cDNA library.
Gregory J. Cole +3 more
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Heparan sulfate proteoglycans in glomerular inflammation [PDF]
Kidney International, 2004 Heparan sulfate proteoglycans (HSPGs) are glycoproteins consisting of a core protein to which linear heparan sulfate side chains are covalently attached. These heparan sulfate side chains can be modified at different positions by several enzymes, which include N-deacetylases, N- and O-sulfotransferases, and an epimerase.
Rops, L.W.M.M. +6 more
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Heparan Sulfate Proteoglycan Signaling in Tumor Microenvironment [PDF]
International Journal of Molecular Sciences, 2020 In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an intriguing subject of study for their complex structural characteristics, their finely regulated biosynthetic machinery, and the wide range of functions they perform in living organisms from development to adulthood.
De Pasquale, Valeria +1 more
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Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression. [PDF]
Front Endocrinol (Lausanne), 2018 Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains. Proteins with covalently bound Heparan sulfate chains are termed Heparan Sulfate Proteoglycans (HSPGs). Both HS and HSPGs bind to various growth factors and act as co-receptors for
Nagarajan A, Malvi P, Wajapeyee N.
europepmc +6 more sources
Wingless, Hedgehog and Heparan Sulfate Proteoglycans [PDF]
Development, 2004 Several recent papers published in Development challenge some of the previous views published by our group and others that: (1) the Drosophila glypican molecules Dally and Dally-like protein (Dlp) are involved in Wingless (Wg) signaling; and (2) Tout-velu/Ext/Ttv affects Hedgehog (Hh) but not ...
Norbert Perrimon, Udo Häcker
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Heparan Sulfate Proteoglycans as Relays of Neuroinflammation. [PDF]
J Histochem Cytochem, 2018 Heparan sulfate proteoglycans (HSPGs) are implicated as inflammatory mediators in a variety of settings, including chemokine activation, which is required to recruit circulating leukocytes to infection sites. Heparan sulfate (HS) polysaccharide chains are highly interactive and serve co-receptor roles in multiple ligand:receptor interactions.
O'Callaghan P, Zhang X, Li JP.
europepmc +5 more sources