Results 11 to 20 of about 40,174 (273)

Heparan Sulfate Proteoglycans: Key Mediators of Stem Cell Function [PDF]

Frontiers in Cell and Developmental Biology, 2020
Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of glycoproteins with exquisite structural complexity. They are ubiquitously expressed across tissues and have been found to exert a multitude of effects on cell behavior and ...
Maanasa Ravikumar, Maanasa Ravikumar, Raymond Alexander Alfred Smith, Victor Nurcombe, Victor Nurcombe, Simon M. Cool, Simon M. Cool   +6 more
doaj   +2 more sources

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling [PDF]

eLife, 2020
R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4,
Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi   +12 more
doaj   +2 more sources

Endocytosis and Trafficking of Heparan Sulfate Proteoglycans in Triple-Negative Breast Cancer Cells Unraveled with a Polycationic Peptide. [PDF]

Int J Mol Sci, 2020
Mandarini E, Tollapi E, Zanchi M, Depau L, Pini A, Brunetti J, Bracci L, Falciani C.   +7 more
europepmc   +3 more sources

Heparan Sulfate Proteoglycans [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Stephane, Sarrazin, William C, Lamanna, Jeffrey D, Esko   +2 more
openaire   +4 more sources

Heparan Sulfate Proteoglycans as Attachment Factor for SARS-CoV‑2 [PDF]

ACS Central Science, 2021
Lin Liu, Pradeep Chopra, Xiuru Li, Kim M. Bouwman, S. Mark Tompkins, Margreet A. Wolfert, Robert P. de Vries, Geert-Jan Boons   +7 more
doaj   +2 more sources

Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis.

Blood
Abstract From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology.
Piszczatowski RT, Bülow HE, Steidl U.
europepmc   +3 more sources

Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias? [PDF]

Viruses, 2019
Cagno V, Tseligka ED, Jones ST, Tapparel C.   +3 more
europepmc   +3 more sources

Alterations in heparan sulfate proteoglycan synthesis and sulfation and the impact on vascular endothelial function

Matrix Biology Plus, 2022
The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular homeostasis.
Danielle Pretorius, Robert P. Richter, Tanya Anand, Jessica C. Cardenas, Jillian R. Richter   +4 more
doaj   +1 more source

Heparan Sulfate: A Regulator of White Adipocyte Differentiation and of Vascular/Adipocyte Interactions

Biomedicines, 2022
White adipose tissues are major endocrine organs that release factors, termed adipokines, which affect other major organ systems. The development and functions of adipose tissues depend largely upon the glycosaminoglycan heparan sulfate.
J. Michael Sorrell, Arnold I. Caplan
doaj   +1 more source

Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. [PDF]

, 2011
Sanfilippo syndrome type B (MPS IIIB) is characterized by profound mental retardation in childhood, dementia and death in late adolescence; it is caused by deficiency of α-N-acetylglucosaminidase and resulting lysosomal storage of heparan sulfate.
Neufeld, Elizabeth F, Ohmi, Kazuhiro, Zhao, Hui-Zhi   +2 more
core   +11 more sources