Results 51 to 60 of about 162,168 (205)

Hepatitis E as a Zoonosis

, 2016
Hepatitis E (HE) virus infection is not limited to spread from human to human but also occurs between animals and more importantly as zoonotic spread from animals to humans. Genotyping of strains from hepatitis E virus-infected patients has revealed that
Widén, Frederik,, Sveriges lantbruksuniversitet.   +1 more
core   +1 more source

Hepatitis mouse models: From acute-to-chronic autoimmune hepatitis

, 2014
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease associated with interface hepatitis, raised plasma liver enzymes, the presence of autoantibodies and regulatory T-cell (Tregs) dysfunction.
Wong, F.S., Yuksel, M., Heindryckx, F., Colle, I., Wen, L., Laukens, D., Van Vlierberghe, H., Geerts, A.   +7 more
core   +1 more source

Animal Models to Study Hepatitis C Virus Infection

Frontiers in Immunology, 2018
With more than 71 million chronically infected people, the hepatitis C virus (HCV) is a major global health concern. Although new direct acting antivirals have significantly improved the rate of HCV cure, high therapy cost, potential emergence of drug ...
Rani Burm, Laura Collignon, Ahmed Atef Mesalam, Ahmed Atef Mesalam, Philip Meuleman   +4 more
doaj   +1 more source

Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail [PDF]

, 2015
A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms
Struthers, M, Tuplin, AK, Tuplin, Andrew, Bentley, K, Struthers, Madeleine, Cook, J, Cook, Jonathan, Evans, DJ, Evans, David J., Struthers, Madeline, Bentley, Kirsten, Cook, Jonathan P.   +11 more
core   +1 more source

Pathobiology and diagnosis of clostridial hepatitis in animals

Journal of Veterinary Diagnostic Investigation, 2019
Clostridia can cause hepatic damage in domestic livestock, and wild and laboratory animals. Clostridium novyi type B causes infectious necrotic hepatitis (INH) in sheep and less frequently in other species. Spores of C. novyi type B can be present in soil; after ingestion, they reach the liver via portal circulation where they persist in phagocytic ...
Mauricio A. Navarro, Francisco A. Uzal
openaire   +5 more sources

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Tuplin, Andrew, Struthers, Madeleine, Struthers, M., Andrew Tuplin, Tuplin, A., Struthers, M, Madeleine Struthers, Simmonds, Peter, David J. Evans, Tuplin, A, Evans, DJ, Peter Simmonds, Evans, David J., Simmonds, P., Evans, D. J., Simmonds, P   +15 more
core   +1 more source

AIC649 Induces a Bi-Phasic Treatment Response in the Woodchuck Model of Chronic Hepatitis B.

PLoS ONE, 2015
AIC649 has been shown to directly address the antigen presenting cell arm of the host immune defense leading to a regulated cytokine release and activation of T cell responses.
Daniela Paulsen, Olaf Weber, Helga Ruebsamen-Schaeff, Bud C Tennant, Stephan Menne   +4 more
doaj   +1 more source

First identification of bovine hepacivirus in wild boars

Scientific Reports, 2022
Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus.
Claudio de Martinis, Lorena Cardillo, Claudia Esposito, Maurizio Viscardi, Lorella Barca, Stefania Cavallo, Nicola D’Alessio, Vito Martella, Giovanna Fusco   +8 more
doaj   +1 more source

Lipid metabolism and HCV infection [PDF]

, 2010
Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body.
Boulant, Steeve, Paul Targett-Adams, Targett-Adams, Paul, Douglas, Mark W., McLauchlan, John, Steeve Boulant, John McLauchlan, Mark W. Douglas   +7 more
core   +1 more source

Animal Models for Hepatitis C Infection Studies

, 2015
Studies on animal models have critical significance in that they cast light on the full comprehension of the HCV infection, and form the foundations of future treatments and possible prevention ...
Aslan, Ferhat Gürkan, Altındiş, Mustafa   +1 more
core   +1 more source