Results 31 to 40 of about 162,168 (205)

Hepatitis delta virus RNA decline post-inoculation in human NTCP transgenic mice is biphasic

mBio, 2023
Chronic infection with hepatitis B and delta viruses (HDV) is the most serious form of viral hepatitis due to more severe manifestations of an accelerated progression to liver fibrosis, cirrhosis, and hepatocellular carcinoma.
Stephanie Maya, Leeor Hershkovich, E. Fabian Cardozo-Ojeda, Elham Shirvani-Dastgerdi, Jay Srinivas, Louis Shekhtman, Susan L. Uprichard, Andrew R. Berneshawi, Thomas R. Cafiero, Harel Dahari, Alexander Ploss   +10 more
doaj   +1 more source

The CYP2D6 animal model: how to induce autoimmune hepatitis in mice

, 2012
Autoimmune hepatitis is a rare but life threatening autoimmune disease of the liver of unknown etiology1,2. In the past many attempts have been made to generate an animal model that reflects the characteristics of the human disease 3-5.
Christen, Urs, Hintermann, Edith, Ehser, Janine   +2 more
core   +1 more source

Animal models of autoimmune hepatitis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019
Many animal models for autoimmune hepatitis (AIH) have been described in the past. Most models had to deal with the relative immunosuppressive environment of the liver. Therefore, some models used a combination of several triggering factors often on a susceptible background to generate an aggressive immune response that targets the liver.
openaire   +2 more sources

Viral hepatitis E: A disease of humans and animals [PDF]

Veterinarski Glasnik, 2012
The hepatitis E virus is ubiquitous in all parts of the world where pig production exists. The infection occurs in several animal species and its course is mostly asymptomatic. Viral strains isolated from pigs and humans are genetically similar,
Kureljušić Branislav, Ivetić Vojin, Savić Božidar, Kureljušić Jasna, Jezdimirović Nemanja   +4 more
doaj   +1 more source

Estimation of hepatitis E virus transmission among pigs due to contact-exposure

, 2008
Locally acquired hepatitis E in humans from industrialized countries has been repeatedly suggested to originate from pigs. Pigs may serve as a reservoir of hepatitis E virus (HEV) for humans when a typical infected pig causes on average more than one ...
Saskia A. Rutjes, Wellenberg, Gerard, van der Poel, W.H.M., Rutjes, Saskia, de Jong, Mart, Frankena, K., de Jong, M.C.M., Rutjes, S.A., van Der Poel, Wim, Poel, W.H.M., van der, Martijn Bouwknegt, Frankena, Klaas, Roda Husman, A.M., de, Mart C.M. de Jong, Gerard J. Wellenberg, Bouwknegt, M., Jong, M.C.M., de, Klaas Frankena, Wellenberg, G.J., de Roda Husman, A.M., Ana Maria de Roda Husman, Bouwknegt, Martijn, Wim H.M. van der Poel, de Roda Husman, Ana Maria   +23 more
core   +1 more source

Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs [PDF]

, 2012
Hepatitis E virus (HEV) is an important but extremely understudied human pathogen. Genotypes 1 and 2 are restricted to humans, whereas genotypes 3 and 4 are zoonotic, infecting both humans and pigs.
Meng, Xiang-Jin, Feagins, Alicia R, Huang, Yao-Wei, Córdoba, Laura, Dryman, Barbara A, Opriessnig, Tanja, Cossaboom, Caitlin M   +6 more
core   +1 more source

Experimental Infection of Rabbits with Rabbit and Genotypes 1 and 4 Hepatitis E Viruses

, 2010
Background: A recent study provided evidence that farmed rabbits in China harbor a novel hepatitis E virus (HEV) genotype. Although the rabbit HEV isolate had 77-79% nucleotide identity to the mammalian HEV genotypes 1 to 4, their genomic organization is
Zheng, L, Ma Yuyuan, Zhang, JG, Liu Yunbo, Zhao, CY, Harrison Tim J., Ma Hongxia, Hongxia Ma, Wang, YC, Wang Youchun, Ma, YY, Yuyuan Ma, Sun, SH, Yunbo Liu, Youchun Wang, Ma, HX, Zhao Chenyan, Harrison, TJ, Zheng Lin, Chenyan Zhao, Jingang Zhang, Zhang Jingang, Tim J Harrison, Lin Zheng, Sun Shuhua, Shuhua Sun, Liu, YB   +26 more
core   +1 more source

Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. [PDF]

, 2010
Specific differences in signaling and antiviral properties between the different Lambda-interferons, a novel group of interferons composed of IL-28A, IL-28B and IL-29, are currently unknown.
Ralf Bartenschlager, Brand, Stephan, Burkhard Göke, Göke, Burkhard, Artur Kaul, Stephan Brand, Beigel, Florian, Kaul, Artur, Kathrin Zitzmann, Helmut M. Diepolder, Diegelmann, Julia, Diepolder, Helmut M., Christoph J Auernhammer, Bartenschlager, Ralf, Helmut M Diepolder, Christoph J. Auernhammer, Julia Diegelmann, Florian Beigel, Zitzmann, Kathrin, Auernhammer, Christoph J.   +19 more
core   +1 more source

Potential Fish Oil as Acute Hepatitis Candidate by Hepatoprotective Mechanism: A-review

JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2023
Acute hepatitis is a health concern that emerged during the COVID-19 outbreak. Toxic drugs, infections, autoimmune diseases, and other causes may induce acute hepatitis, which is deadly. Acute hepatitis isn't treatable.
Heru Sasongko, Muhammad Fiqri Zulpadly, Yeni Farida   +2 more
doaj   +1 more source

Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors

, 2010
Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined.
Christiane Brohm, Kathrin Hueging, Michael Ott, Hueging, Kathrin, Brohm, Christiane, Ott, Michael, Bitzegeio, Julia, Dorothea Bankwitz, Herrmann, Eva, Sibylle Haid, Thomas Pietschmann, Mirjam B. Zeisel, Baumert, Thomas F, Iken, Marcus, Haid, Sibylle, Marcus Iken, Julia Bitzegeio, Thomas F. Baumert, Zeisel, Mirjam B, Thomas F Baumert, Mirjam B Zeisel, Eva Herrmann, Baumert, Thomas, Bankwitz, Dorothea, Zeisel, Mirjam B., Pietschmann, Thomas   +25 more
core   +1 more source