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Animal Models for Hepatitis E Virus [PDF]
Viruses, 2019 Hepatitis E virus (HEV) is an underdiagnosed pathogen with approximately 20 million infections each year and currently the most common cause of acute viral hepatitis.
Laura Corneillie +2 more
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Zoonotic Hepatitis E Virus: Classification, Animal Reservoirs and Transmission Routes
Viruses, 2016 During the past ten years, several new hepatitis E viruses (HEVs) have been identified in various animal species. In parallel, the number of reports of autochthonous hepatitis E in Western countries has increased as well, raising the question of what role
Virginie Doceul +3 more
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Animal Models of Hepatitis B Virus Infection–Success, Challenges, and Future Directions
Viruses, 2021 Chronic hepatitis B virus (HBV) infection affects more than 250 million people worldwide, which greatly increases the risk for terminal liver diseases, such as liver cirrhosis and hepatocellular carcinoma (HCC).
Yongzhen Liu +2 more
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Mechanism of Cross-Species Transmission, Adaptive Evolution and Pathogenesis of Hepatitis E Virus
Viruses, 2021 Hepatitis E virus (HEV) is the leading cause of acute hepatitis worldwide. While the transmission in developing countries is dominated by fecal-oral route via drinking contaminated water, the zoonotic transmission is the major route of HEV infection in ...
Putu Prathiwi Primadharsini +2 more
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Animal Models for Hepatitis E Virus
, 2016 Animal models are one of the most important tools in the study of human hepatitis E virus (HEV) infection. They are particularly important in light of the major limitations of the cell culture system for HEV. Besides nonhuman primates, which are extremely valuable because of their susceptibility to HEV genotypes 1-4, animals like swine, rabbit, and ...
Lin, Wang, Ling, Wang
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HCV Animal Models: A Journey of More than 30 Years [PDF]
Viruses, 2009 In the 1970s and 1980s it became increasingly clear that blood transfusions could induce a form of chronic hepatitis that could not be ascribed to any of the viruses known to cause liver inflammation.
Philip Meuleman, Geert Leroux-Roels
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Viruses, 2017 The human Hepatitis Delta Virus (HDV) is unique among all viral pathogens. Encoding only one protein (Hepatitis Delta Antigen; HDAg) within its viroid-like self-complementary RNA, HDV constitutes the smallest known virus in the animal kingdom.
Florian A. Lempp, Stephan Urban
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Hepatitis E virus immunosuppressed animal models
BMC Infectious DiseasesHepatitis E virus (HEV) is an important emerging pathogen producing significant morbidity in immunosuppressed patients. HEV has been detrimental to solid organ transplant (SOT) patients, cancer patients, and HIV-positive patients, where chronic HEV ...
Kush Kumar Yadav, Scott P. Kenney
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Animal Models of Hepatitis A and E [PDF]
ILAR Journal, 2001 Several useful animal models for both hepatitis A and E have been identified, characterized, and refined. At present, all of the best models utilize nonhuman primates: chimpanzees, tamarin species, and owl monkeys for hepatitis A; and macaque species, chimpanzees, and owl monkeys for hepatitis E.
R H, Purcell, S U, Emerson
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Targeting Host Innate and Adaptive Immunity to Achieve the Functional Cure of Chronic Hepatitis B
Vaccines, 2020 Despite the availability of an effective preventive vaccine for hepatitis B virus (HBV) for over 38 years, chronic HBV (CHB) infection remains a global health burden with around 257 million patients. The ideal treatment goal for CHB infection would be to
Sayeh Ezzikouri +4 more
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