Results 1 to 10 of about 162,168 (205)

Evidence of Rat Hepatitis E Virus Circulation through Wastewater Surveillance, Central Argentina. [PDF]

Emerg Infect Dis
During 2023–2024, we detected rat hepatitis E virus in 67.7% of wastewater samples from central Argentina. This high level of detection opens new inquiries in the region, highlighting the need to investigate the virus in both animal reservoirs and ...
Abravanel F, Castille C, Marter N, Guerin JL, Lhomme S, Izopet J.   +5 more
europepmc   +2 more sources

Natural Hepacivirus Infection in Tree Shrews: A Call for Routine Screening in Hepatitis Virus Research. [PDF]

Viruses
Hepatitis viruses continue to pose major global health challenges, necessitating the development of reliable and well-characterized experimental models.
Kayesh MEH, Sanada T, Kohara M, Tsukiyama-Kohara K.   +3 more
europepmc   +2 more sources

Immunogenicity and safety in animals of a lyophilized live attenuated hepatitis A vaccine following stabilizer optimization. [PDF]

Sci Rep
To evaluate the immunogenicity and safety profiles of lyophilized hepatitis A live attenuated vaccine (L-A-1 attenuated strain) after stabilizer formula optimization using non-human primates and various rodent models.
Wang Y, Xia Q, Li C, Wu P, Yue L, Wang X, Bai G, Zheng S, Xu Y.   +8 more
europepmc   +2 more sources

Presence and Diversity of Different Enteric Viruses in Wild Norway Rats (Rattus norvegicus)

Viruses, 2021
Rodents are common reservoirs for numerous zoonotic pathogens, but knowledge about diversity of pathogens in rodents is still limited. Here, we investigated the occurrence and genetic diversity of enteric viruses in 51 Norway rats collected in three ...
Sandra Niendorf, Dominik Harms, Katja F. Hellendahl, Elisa Heuser, Sindy Böttcher, Sonja Jacobsen, C.-Thomas Bock, Rainer G. Ulrich   +7 more
doaj   +1 more source

A small animal model of chronic hepatitis E infection using immunocompromised rats

JHEP Reports, 2022
Background & Aims: HEV variants such as swine genotypes within Paslahepevirus species balayani (HEV-A) and rat HEV (Rocahepevirus ratti; HEV-C1) cause chronic hepatitis E in immunocompromised individuals.
Siddharth Sridhar, Shusheng Wu, Jianwen Situ, Estie Hon-Kiu Shun, Zhiyu Li, Anna Jin-Xia Zhang, Kyle Hui, Carol Ho-Yan Fong, Vincent Kwok-Man Poon, Nicholas Foo-Siong Chew, Cyril Chik-Yan Yip, Wan-Mui Chan, Jian-Piao Cai, Kwok-Yung Yuen   +13 more
doaj   +1 more source

Progress of hepatitis B virus-associated neutralizing antibody in antiviral therapy of chronic hepatitis B [PDF]

Xin yixue, 2022
Chronic hepatitis B virus infection is not only an important global public health problem but also an important challenge in our country. Although there are some vaccines for hepatitis B and its prevalence is increasing year by year, there are still many
Zhao Yudi, Huang Mingxing
doaj   +1 more source

Recent Drug Development in the Woodchuck Model of Chronic Hepatitis B

Viruses, 2022
Infection with hepatitis B virus (HBV) is responsible for the increasing global hepatitis burden, with an estimated 296 million people being carriers and living with the risk of developing chronic liver disease and cancer.
Manasa Suresh, Stephan Menne
doaj   +1 more source

Animal Models for Autoimmune Hepatitis: Are Current Models Good Enough?

Frontiers in Immunology, 2022
Autoimmune liver diseases like autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and IgG4-related cholangitis are chronic inflammatory diseases of the liver with an autoimmune background.
Urs Christen, Edith Hintermann
doaj   +1 more source

COMMD1-deficient dogs accumulate copper in hepatocytes and provide a good model for chronic hepatitis and fibrosis. [PDF]

PLoS ONE, 2012
New therapeutic concepts developed in rodent models should ideally be evaluated in large animal models prior to human clinical application. COMMD1-deficiency in dogs leads to hepatic copper accumulation and chronic hepatitis representing a Wilson's ...
Robert P Favier, Bart Spee, Baukje A Schotanus, Ted S G A M van den Ingh, Hille Fieten, Bas Brinkhof, Cornelia S Viebahn, Louis C Penning, Jan Rothuizen   +8 more
doaj   +1 more source

Characterization of innate immune response to hepatitis B virus genotype F acute infection in tree shrew (Tupaia belangeri) model

Frontiers in Virology, 2022
Hepatitis B virus (HBV) infection is a global public health problem. The clinical outcomes of HBV infections are influenced by host as well as viral factors, including viral genotypes and subgenotypes.
Mohammad Enamul Hoque Kayesh, Mohammad Enamul Hoque Kayesh, Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Md Abul Hashem, Takahiro Sanada, Bouchra Kitab, Bouchra Kitab, Md Haroon Or Rashid, Md Haroon Or Rashid, Lipi Akter, Sayeh Ezzikouri, Shuko Murakami, Shintaro Ogawa, Yasuhito Tanaka, Michinori Kohara, Kyoko Tsukiyama-Kohara, Kyoko Tsukiyama-Kohara   +17 more
doaj   +1 more source