Animal Models for Hepatitis E Virus [PDF]
Viruses, 2019 Hepatitis E virus (HEV) is an underdiagnosed pathogen with approximately 20 million infections each year and currently the most common cause of acute viral hepatitis.
Laura Corneillie +2 more
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Advances and perspectives in animal models of human hepatitis A virus [PDF]
Animal Models and Experimental MedicineHepatitis A virus (HAV) is an important pathogen that has continuously posed a threat to global public health for over 5000 years. The development of accessible and reliable small animal models, especially murine models, is essential for elucidating HAV ...
Jian Li +3 more
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Evidence of Rat Hepatitis E Virus Circulation through Wastewater Surveillance, Central Argentina [PDF]
Emerging Infectious DiseasesDuring 2023–2024, we detected rat hepatitis E virus in 67.7% of wastewater samples from central Argentina. This high level of detection opens new inquiries in the region, highlighting the need to investigate the virus in both animal reservoirs and ...
Bianca Filoni +12 more
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Presence and Diversity of Different Enteric Viruses in Wild Norway Rats (Rattus norvegicus)
Viruses, 2021 Rodents are common reservoirs for numerous zoonotic pathogens, but knowledge about diversity of pathogens in rodents is still limited. Here, we investigated the occurrence and genetic diversity of enteric viruses in 51 Norway rats collected in three ...
Sandra Niendorf +7 more
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A small animal model of chronic hepatitis E infection using immunocompromised rats
JHEP Reports, 2022 Background & Aims: HEV variants such as swine genotypes within Paslahepevirus species balayani (HEV-A) and rat HEV (Rocahepevirus ratti; HEV-C1) cause chronic hepatitis E in immunocompromised individuals.
Siddharth Sridhar +13 more
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Progress of hepatitis B virus-associated neutralizing antibody in antiviral therapy of chronic hepatitis B [PDF]
Xin yixue, 2022 Chronic hepatitis B virus infection is not only an important global public health problem but also an important challenge in our country. Although there are some vaccines for hepatitis B and its prevalence is increasing year by year, there are still many
Zhao Yudi, Huang Mingxing
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Recent Drug Development in the Woodchuck Model of Chronic Hepatitis B
Viruses, 2022 Infection with hepatitis B virus (HBV) is responsible for the increasing global hepatitis burden, with an estimated 296 million people being carriers and living with the risk of developing chronic liver disease and cancer.
Manasa Suresh, Stephan Menne
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Animal Models of Hepatitis A and E [PDF]
ILAR Journal, 2001 Several useful animal models for both hepatitis A and E have been identified, characterized, and refined. At present, all of the best models utilize nonhuman primates: chimpanzees, tamarin species, and owl monkeys for hepatitis A; and macaque species, chimpanzees, and owl monkeys for hepatitis E.
R H, Purcell, S U, Emerson
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Animal Models for Autoimmune Hepatitis: Are Current Models Good Enough?
Frontiers in Immunology, 2022 Autoimmune liver diseases like autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and IgG4-related cholangitis are chronic inflammatory diseases of the liver with an autoimmune background.
Urs Christen, Edith Hintermann
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COMMD1-deficient dogs accumulate copper in hepatocytes and provide a good model for chronic hepatitis and fibrosis. [PDF]
PLoS ONE, 2012 New therapeutic concepts developed in rodent models should ideally be evaluated in large animal models prior to human clinical application. COMMD1-deficiency in dogs leads to hepatic copper accumulation and chronic hepatitis representing a Wilson's ...
Robert P Favier +8 more
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