Results 181 to 190 of about 17,474,409 (256)

Cyclin‐dependent kinase 4/6 (CDK4/6) inhibitor‐induced hepatotoxicity and its resolution: a study of seven cases

Histopathology, EarlyView.
CDK4/6 inhibitor‐induced liver injury represents a clinically significant and histologically distinctive form of drug‐induced hepatotoxicity, most commonly encountered with ribociclib. The predominant pattern is severe acute hepatocellular injury, frequently accompanied by lymphocytic cholangitis, a combination that, in the appropriate clinical context,
Sunayana Misra, Lisa Centeno, Dupinder Singh, Romil Saxena, Rifat Mannan   +4 more
wiley   +1 more source

Same‐night PrEP in community care: The Nightcafé model for male and transgender sex workers

HIV Medicine, EarlyView.
Abstract Introduction Despite high risk of HIV infection, uptake of pre‐exposure prophylaxis (PrEP) remains limited among male and transgender sex workers (MSW and TSW), and data on tailored interventions to improve access are scarce. The Nightcafé programme addresses this gap by offering low‐threshold PrEP provision in a community‐centred setting ...
Elena Heizmann, Andrea Farnham, Christian Grolimund, Jorge Flores Real, Paul Halm, Veronika Braig, Hadrien Komaromi, Giulietta Mila Laffers, Jan Fehr, Benjamin Hampel   +9 more
wiley   +1 more source

Hepatitis D virus infection in persons with HIV and hepatitis B virus across Europe: A cross‐sectional analysis of the HDV‐Europe cohort

HIV Medicine, EarlyView.
Abstract Introduction Infection with hepatitis D virus (HDV) is known to accelerate the progression of liver disease and is associated with mortality in individuals with HIV and hepatitis B virus (HBV). However, little is known about current HDV epidemiology, including HDV‐testing practices and prevalence, in this population in Europe.
Anders Boyd, Thomas Lutz, Kathrin van Bremen, Alessandro Tavelli, Antonella d'Arminio Monforte, Marc van der Valk, Miłosz Parczewski, Magdalena Tchorz, Iwona Cielniak, Luz Martín‐Carbonero, María del Mar Arcos‐Rueda, Charles Béguelin, Gilles Wandeler, Sanjay Bhagani, Charlotte Lim, Fauzi Elamouri, Juan Berenguer, Jürgen K. Rockstroh, Pablo Ryan   +18 more
wiley   +1 more source

Chronic alanine aminotransferase elevation in people with HIV: Time trends over 22 years and genetic predisposition

HIV Medicine, EarlyView.
Abstract Introduction Chronic elevation of alanine aminotransferase (cALT) is common in people with HIV. Published reports on cALT prevalence time trends have not been uniform. It is unknown whether genetic background is associated with cALT in people with HIV. Methods cALT was defined as ALT levels (male, >50 U/L, female, >35 U/L) at ≥2 consecutive, 6‐
Noemi R. Simon, Carlotta Mondoka, Christian W. Thorball, Isabella C. Schoepf, Lene Ryom, Irene Abela, Charles Béguelin, Urs Führer, Helen Kovari, Catia Marzolini, Annalisa Marinosci, Christian Kahlert, Luigia Elzi, David Haerry, Matthias Cavassini, Bruno Ledergerber, Jacques Fellay, Gilles Wandeler, Philip E. Tarr, the Swiss HIV Cohort Study, IA Abela, K Aebi‐Popp, A Anagnostopoulos, E Bernasconi, A Boyd, DL Braun, HC Bucher, A Calmy, M Cavassini, SE Chaudron, A Ciuffi, G Dollenmaier, M Egger, L Elzi, JS Fehr, J Fellay, S Frigerio Malossa, CA Fux, HF Günthard, A Hachfeld, DHU Haerry, B Hasse, M Hoffmann, M Huber, D Jackson‐Perry, CR Kahlert, D Kaufmann, O Keiser, RD Kouyos, H Kovari, K Kusejko, ND Labhardt, K Leuzinger, C Marzolini, KJ Metzner, N Müller, J Nemeth, D Nicca, J Notter, P Paioni, M Perreau, A Rauch, LP Salazar‐Vizcaya, P Schmid, O Segeral, RF Speck, M Stöckle, B Surial, PE Tarr, A Trkola, G Wandeler, M Weisser, S. Yerly   +72 more
wiley   +1 more source

Sexually Transmitted Infection Prevalence and Determinants Among Sexual Health Clinic Attendees in Bucharest, Romania

International Journal of Dermatology, EarlyView.
Cross‐sectional study among 70 sexual health clinic attendees (70% MSM) in Bucharest combining multisite STI testing with knowledge, attitudes, and practices assessment. Key findings include 35.5% bacterial STI prevalence, essential extragenital testing, and cost barriers to screening uptake.
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

ANZTCT cytomegalovirus practice survey for allogeneic haemopoietic stem cell transplant and cellular therapy recipients in Australia and New Zealand

Internal Medicine Journal, EarlyView.
Abstract Background Despite pre‐emptive treatment (PeT), cytomegalovirus (CMV) disease and reactivation remain a clinical concern. In Australia and New Zealand (ANZ), variability exists in the management of CMV for haematopoietic stem cell transplantation (HSCT) recipients.
Andrea Henden, Lynette Chee, Julia Clark, Rachel Conyers, Julian Cooney, Richard Doocey, David Gottlieb, Tim Prestidge, Madeleine Powys, Philip Selby, Gaurav Sutrave, Eric Wong, Michelle K. Yong, Nada Hamad   +13 more
wiley   +1 more source

Preventing infections after CD19‐directed chimeric antigen receptor T‐cell therapies for lymphoma: a consensus practice statement

Internal Medicine Journal, EarlyView.
Abstract Chimeric antigen receptor (CAR) T‐cell therapies directed against cluster of differentiation 19 (CD19) are a standard of care for relapsed or refractory B‐cell lymphomas. Infection is the leading cause of non‐relapse mortality, and this risk may persist for years after CAR T‐cell receipt.
Aine Hurley, Philip George, Gemma Reynolds, Adam Stewart, Hang Quach, Nicole O'Leary, Zoe McQuilten, Andrea S. Henden, Lynette Chee, Chan Y. Cheah, Olivia Bupha‐Intr, Emily Blyth, Ben Teh, Monica Slavin, Michael Dickinson, Robert Weinkove   +15 more
wiley   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

TIM‐3 Functions as an Activator of NK Cells in GBM and Can Be Upregulated by Torin‐1: Implications for Exogenous NK Cell Transplantation

Immunology, EarlyView.
Unlike generalized mTOR inhibitors, Torin‐1 uniquely drives compensatory upregulation of TIM‐3 on human NK cells, shielding them from immunosuppression while concurrently inhibiting glioblastoma (GBM) growth. Selecting or preconditioning ex vivo NK cell products for high TIM‐3 expression can offer a combination strategy for adoptive cell therapy in GBM.
Yuning Liu, Tram Dao, Shambhavi Borde, Diana Dinh, Sofia Lombardi, Sandra Torregrosa‐Allen, Haley A. Harper, Veronika Slivova, Aaron Cohen‐Gadol, MacKenzie McIntosh, Bennet D. Elzey, Sandro Matosevic   +11 more
wiley   +1 more source