Advanced Science, EarlyView.USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian +9 more
wiley +1 more source
Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]
, 2007 A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Camacho, F. +15 more
core +1 more source
Hepatitis B virus x protein coding sequence variation in chronically infected patient
مجله دانشگاه علوم پزشکی گرگان, 2017 Background and Objective: Chronic infection with Hepatitis B virus (HBV) is one of the main causes of cirrhosis and hepatocellular carcinoma (HCC). The pathogenicity of the virus is determined by the multi-functional protein x (HBx).
A Mohebbi +6 more
doaj
Hepatitis B virus induces hypoxia-inducible factor-2α expression through hepatitis B virus X protein
Oncology Reports, 2015 A growing number of studies suggest that the hepatitis B virus X protein (HBx) enhances the protein stability of the hypoxia-inducible factor-1α (HIF-1α). However, the relationship between hepatitis B virus (HBV), HBx and hypoxia-inducible factor-2α (HIF-2α) has not yet been fully elucidated.
Jian-Li, Hu +6 more
openaire +3 more sources
Advanced Science, EarlyView.Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang +4 more
wiley +1 more source
Hepatitis B virus infection in the Republic of Yemen [PDF]
A community-based cross-sectional household seroepdemiological survey was conducted in the Republic of Yemen to estimate the prevalence of HBV infection as well as hepatitis B vaccine coverage and effectiveness amongst children vaccinated in the ...
Qirbi, Naseeb
core +1 more source
Seroepidemiology of hepatitis B virus in Addis Ababa Ethiopia: transmission patterns and vaccine control [PDF]
, 2003 A community-based seroepidemiological survey of Addis Ababa, Ethiopia was conducted in 1994 to inform on the transmission dynamics and control of hepatitis B virus (HBV) infection.
Cutts, FT +11 more
core +1 more source
Molecular characterization of hepatitis B virus X gene in chronic hepatitis B patients
Virology Journal, 2012 Background HBV-X protein is associated with the pathogenesis of HBV related diseases, specially in hepatocellular carcinomas of chronic patients. Genetic variability of the X gene includes genotypic specific variations and mutations emerging during ...
Barbini Luciana +4 more
doaj +1 more source
Global re‐wiring of p53 transcription regulation by the hepatitis B virus X protein
Molecular Oncology, 2016 Background The tumour suppressor p53 is a central player in transcription regulation and cell fate determination. By interacting with p53 and altering its sequence‐specific binding to the response elements, the hepatitis B virus X protein (HBx) was ...
Cheryl Chan +6 more
doaj +1 more source
Reconstitution of hepatitis B virus (HBV)-specific T cell responses with treatment of human immunodeficiency virus/HBV coinfection [PDF]
, 2003 Liver-related mortality is an increasing problem in human immunodeficiency virus (HIV)/hepatitis B virus (HBV)-coinfected patients receiving highly active antiretroviral therapy (HAART).
Gilson, RJ +4 more
core