Results 91 to 100 of about 24,189 (241)

Tibolone Use Associated With Elevated Hepatocellular Carcinoma Risk: Findings From a Nationwide Cohort

International Journal of Cancer, EarlyView.
ABSTRACT Tibolone, a synthetic steroid with estrogenic, progestogenic, and androgenic activity, is widely prescribed for menopausal symptoms, but its association with hepatocellular carcinoma (HCC) remains unclear. Using data from 117,271 women aged ≥ 45 years in the Korean National Health Insurance Service–Health Screening Cohort, we evaluated ...
Jimin Lee, Hye Jun Kim, Sun Jae Park, Sangwoo Park, Jina Chung, Jiwon Yu, Ju Hyun Kang, Seogsong Jeong, Hyun‐Young Shin, Sang Min Park   +9 more
wiley   +1 more source

Role of the Mitochondrial Citrate-malate Shuttle in Hras12V-Induced Hepatocarcinogenesis: A Metabolomics-Based Analysis

Metabolites, 2020
The activation of the Ras signaling pathway is a crucial process in hepatocarcinogenesis. Till now, no reports have scrutinized the role of dynamic metabolic changes in Ras oncogene-induced transition of the normal and precancerous liver cells to ...
Chuanyi Lei, Jun Chen, Huiling Li, Tingting Fan, Xu Zheng, Hong Wang, Nan Zhang, Yang Liu, Xiaoqin Luo, Jingyu Wang, Aiguo Wang   +10 more
doaj   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury

, 2011
*Department of Medicine III, University Hospital, Aachen, Germany; ‡Department of Radiology, Justus-Liebig University, Giessen, Germany; §Institute of Pathology, University Hospital Aachen, Germany; and Human Genetics Division, University of ...
Liedtke, Christian, Trautwein, Christian, Cubero Palero, Francisco Javier   +2 more
core   +1 more source

Absence of progressive liver disease after treatment in children with chronic hepatitis C: A nationwide registry study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives In adults with chronic hepatitis C (CHC) and advanced fibrosis, hepatocellular carcinoma (HCC) surveillance is recommended after achieving a sustained virologic response (SVR). However, post‐SVR surveillance strategies for children remain unclear. The aim of this study was to assess the durability of SVR and determine an appropriate
Hitoshi Tajiri, Mitsuyoshi Suzuki, Yuri Etani, Yoshinori Ito, Koichi Ito, Tomoya Fukuoka, Tatsuki Mizuochi   +6 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling

Cancer Science, EarlyView.
Psychological stress promotes hepatocellular carcinoma progression through coordinated regulation of macrophages and neutrophils. Noradrenaline activates ADRB2 signaling in intratumoral macrophages, leading to CXCL2 production and neutrophil recruitment.
Keita Ogawa, Takahiro Aoki, Tatsuya Kaneko, Hongxuan Wang, Daiki Shimizu, Daisuke Katsumi, Iori Kojima, Hidekazu Tanaka, Kiwamu Motoyoshi, Ko Ozaki, Katsuhiro Nishimura, Tomohisa Iinuma, Mariko Takami, Shinichiro Motohashi   +13 more
wiley   +1 more source

Chronic liver inflammation and hepatocellular carcinoma: persistence matters

Swiss Medical Weekly, 2011
Inflammatory responses in the liver – a central constituent of hepatic wound healing – can be self-limited or persistent depending on the aetiology, liver health state, concentration of toxins or pathogens, and the time frame of exposure to toxins or ...
YT Boege, F Reisinger, M Heikenwalder
doaj   +1 more source

Toward a Synthetic Data Revolution: Diffusion Model‐Enhanced Hepatocellular Carcinoma Prediction in Steatotic Liver Disease

Hepatology Research, EarlyView.
ABSTRACT Aim Steatotic liver disease (SLD) encompasses a heterogeneous spectrum with varying risks of hepatocellular carcinoma (HCC). Limited sample sizes limit the development of predictive models, particularly for rare outcomes. This study evaluated whether generative artificial intelligence (AI)‐based synthetic data augmentation can enhance HCC risk
Masaya Sato, Takuma Nakatsuka, Yuki Matsushita, Takuma Kaneko, Keisuke Mabuchi, Tomoharu Yamada, Kazuya Okushin, Tatsuya Minami, Yotaro Kudo, Satoshi Kodera, Kazuhiko Koike, Mitsuhiro Fujishiro, Ryosuke Tateishi   +12 more
wiley   +1 more source

Predictors of hepatocellular carcinoma recurrence associated with the use of direct‐acting antiviral agent therapy for hepatitis C virus after curative treatment: A prospective multicenter cohort study

Cancer Medicine, 2019
Background Previous studies have suggested an association between the use of direct‐acting antiviral agents (DAAs) for treating hepatitis C virus (HCV) infection and the resulting decrease in the incidence of hepatocellular carcinoma (HCC); however, it ...
Masahito Nakano, Hironori Koga, Tatsuya Ide, Ryoko Kuromatsu, Satoru Hashimoto, Hiroshi Yatsuhashi, Masataka Seike, Nobito Higuchi, Makoto Nakamuta, Satoshi Shakado, Shotaro Sakisaka, Satoshi Miuma, Kazuhiko Nakao, Yoko Yoshimaru, Yutaka Sasaki, Satoshi Oeda, Yuichiro Eguchi, Yuichi Honma, Masaru Harada, Kenji Nagata, Seiichi Mawatari, Akio Ido, Tatsuji Maeshiro, Shuichi Matsumoto, Yuko Takami, Tetsuo Sohda, Takuji Torimura   +26 more
doaj   +1 more source