Results 81 to 90 of about 24,189 (241)

The expression of stemness features in B viral multistep hepatocarcinogenesis.

, 2017
A) Representative features of EpCAM, K19, and CD133 expression in LGDNs, HGDNs, eHCCs, and pHCCs are presented. Original magnification x200. Inset, high power magnification x400.
Young-Joo Kim (1955062), Haeryoung Kim (3692143), Jeong Eun Yoo (616105), Hyungjin Rhee (616104), Jin Sub Choi (616108), Ei Yong Ahn (3692146), Young Nyun Park (149284), Massimo Roncalli (17647)   +7 more
core   +1 more source

The enigma of RIPK1 in the liver: More than just a kinase

Molecular & Cellular Oncology, 2017
Receptor interacting protein kinase 1 (RIPK1) represents a key molecule in cell death. Here, we discuss our recent data on RIPK1 in liver injury and hepatocellular carcinoma development and put these into relation to previous experimental findings to ...
Mihael Vucur, Anne T. Schneider, Jérémie Gautheron, Tom Luedde   +3 more
doaj   +1 more source

Dynamics of Genomic, Epigenomic, and Transcriptomic Aberrations during Stepwise Hepatocarcinogenesis

, 2019
Hepatocellular carcinoma (HCC) undergoes a stepwise progression from liver cirrhosis to low-grade dysplastic nodule (LGDN), high-grade dysplastic nodule (HGDN), early HCC (eHCC), and progressed HCC (pHCC).
Woo, HG, Kwon, SM, Jee, BA, Choi, GH, Park, YN, Yoon, S, Rhee, H, Choi, JH, Yoo, JE, Nahm, JH, Jeon, Y   +10 more
core   +2 more sources

New insight into the role of autophagy in tumorigenesis

Cell Stress, 2017
Autophagy plays an important role in maintaining cellular homeostasis. Its dysfunction can cause many diseases, including neurodegenerative diseases, metabolic diseases and cancer.
Yongjun Tian, Linya Wang, Jing-hsiung James Ou   +2 more
doaj   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio
Hepatocellular carcinoma (HCC) is among the most common causes of cancer‐related deaths worldwide. Previous studies showed that N6‐methyladenosine (m6A), the most abundant chemical modification in eukaryotic RNAs, is implicated in HCC progression.
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
doaj   +1 more source

Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia. [PDF]

, 2008
BACKGROUND: Little is known about changes in hepatitis B viral load (HBV DNA) in relation to age in Africa. The aim of this study is to determine the natural course of HBV chronic infection, particularly in relation to sequential changes in serum HBV DNA
Jeffries, David, Kaye, Steve, Hilton C. Whittle (7946705), David Jeffries, Maimuna E Mendy, Samuel J McConkey, Steve Kaye, Samuel McConkey (7896113), Marianne AB Sande van der (7946780), Kaye Steve, Mendy, Maimuna E, Maimuna E. Mendy (7946657), Hall, Andrew J, Mendy Maimuna E, Andrew J Hall, Crozier, Sarah, McConkey, Samuel J, Sarah Crozier (46005), Sande van der, Marianne AB, Steve Kaye (46006), Whittle, Hilton C, Andrew J. Hall (78002), Whittle Hilton C, Sande van der Marianne AB, Hilton C Whittle, Marianne AB Sande van der, David Jeffries (46007), Sarah Crozier, Jeffries David, McConkey Samuel J, Hall Andrew J, Crozier Sarah   +31 more
core   +1 more source

Evolutionary View of Liver Pathology

Evolutionary Applications
Evolutionary medicine emerged in the late twentieth century, integrating principles of natural selection and adaptation with the health sciences. Today, with a rapidly widening gap between the biology of Homo sapiens and its environment, maladaptation or
Katalin Dezső, Sándor Paku, Mária‐Manuela Juhász, László Kóbori, Péter Nagy   +4 more
doaj   +1 more source

Hepatic immunopathogenesis of Crimean-Congo hemorrhagic fever virus: from acute liver injury to hypothesis-driven links with hepatocarcinogenesis [PDF]

Exploration of Digestive Diseases
Crimean-Congo hemorrhagic fever virus (CCHFV) is a globally distributed, highconsequence zoonotic pathogen whose clinical spectrum extends far beyond hemorrhagic diathesis.
Meisam Akrami, Maryam Akrami, Amirhossein Amini, Mohammad Jebeli   +3 more
doaj   +1 more source

Genetic alterations and epigenetic changes in hepatocarcinogenesis

, 2007
<p class="MsoNormal"><span style="font-size: 10pt; font-family: QuorumITCbyBT-Book">Hepatocarcinogenesis as hepatocellular carcinoma (HCC) is associated with background of chronic liver disease usually in association with cirrhosis, marked ...
Luz Stella Hoyos Giraldo
core   +2 more sources

Immunopathogenesis of Hepatitis B Virus Infection and Related Complications [PDF]

European Medical Journal Hepatology, 2016
Chronic hepatitis B (CHB) is a serious consequence of hepatitis B virus (HBV), which infects and replicates in the liver. It is characterised by prolonged hepatitis B surface antigen seropositivity; this can lead to both cirrhosis and hepatocellular ...
Mankgopo M. Kgatle, Mashiko Setshedi
doaj