Results 61 to 70 of about 24,189 (241)

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

DataSheet_1_3,5,3′-Triiodothyronine–Loaded Liposomes Inhibit Hepatocarcinogenesis Via Inflammation-Associated Macrophages.docx

, 2022
BackgroundHepatocellular carcinoma (HCC) is inflammation-related cancer. Persistent inflammatory injury of the liver is an important factor mediating the occurrence and development of liver cancer.
Hengyan Zhang (6831760), Xiaojuan Hou (6028322), Chen Zong (537910), Gangqi Sun (12521569), Junxia Shi (7916642), Changchun Shao (10955965), Luyao Zhang (1842607), Xue Yang (144876), Rong Li (72042), Fengwei Li (5798753), Li Zhang (8200)   +10 more
core   +1 more source

Biological Roles of Hepatitis B Viral X Protein in the Viral Replication and Hepatocarcinogenesis [PDF]

, 2023
Hepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins.
Otsuka, Motoyuki
core   +1 more source

Regulation of hepatocarcinogenesis by microRNAs

Frontiers in Bioscience, 2013
Liver cancer (hepatocellular carcinoma, HCC) is a major malignancy worldwide. Etiologically, hepatocarcinogenesis is closely associated with HBV and HCV infections; however, its underlying molecular mechanism is not completely understood. MicroRNAs are a class of small non-coding RNAs that negatively regulate gene expression by interacting with the 3 ...
Chun-Ming, Wong, Alan Ka-Lun, Kai, Felice Ho-Ching, Tsang, Irene Oi-Lin, Ng   +3 more
openaire   +2 more sources

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

CAMK2γ Antagonizes mTORC1 Activation during Hepatocarcinogenesis

, 2016
Hepatocellular carcinoma (HCC) is one of the most deadly cancers that still lacks effective treatments. Dysregulation of kinase signaling has frequently been reported to contribute to HCC.
Gan, Xiaoxian, Van Ness, Carl, Han, Weidong, Ma, Xiaoxiao, Du, Juan, Fu, Xianghui, Meng, Zhipeng, He, Min, Gu, Ying, Schones, Dustin E, Huang, Wendong, Zhang, Jiawei, Xu, Rongzhen, Fang, Zhipeng, Wang, Xiaoqiong   +14 more
core   +1 more source

Hepatocarcinogenesis and Ceramide/Cholesterol Metabolism [PDF]

Anti-Cancer Agents in Medicinal Chemistry, 2012
Sphingolipids (SLs) and cholesterol are critical structural components of membrane bilayers. Although recent evidence has revealed an emerging role of both lipids in signaling pathways, their contribution to cancer development and treatment has been largely overlooked. Sphingolipids comprise a family of bioactive lipids with divergent roles in numerous
Morales, Albert, Marí, Montserrat, García-Ruiz, Carmen, Colell Riera, Anna, Fernández-Checa, José C.   +4 more
openaire   +3 more sources

Preneoplastic lesions in human hepatocarcinogenesis

, 2005
The early stages of hepatocarcinogenesis in human chronic liver diseases are characterized by the emergence of preneoplastic lesions of which some will eventually develop into hepatocellular carcinoma (HCC).
Roskams, Tania, Desmet, Valeer, Libbrecht, Louis   +2 more
core   +1 more source

Protective Role of Decorin in Primary Hepatocellular Carcinoma

Frontiers in Oncology, 2020
Hepatocellular carcinoma (HCC) represents one of the most frequent type of primary liver cancers. Decorin, a small leucine-rich proteoglycan of the extracellular matrix, represents a powerful tumor cell growth and migration inhibitor by hindering ...
Andrea Reszegi, Zsolt Horváth, Hajnalka Fehér, Barnabás Wichmann, Péter Tátrai, Ilona Kovalszky, Kornélia Baghy   +6 more
doaj   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source