Results 71 to 80 of about 24,189 (241)

Role of Gut Microbiota in Hepatocarcinogenesis [PDF]

Microorganisms, 2019
Hepatocellular carcinoma (HCC), one of the leading causes of death worldwide, has a causal nexus with liver injury, inflammation, and regeneration that accumulates over decades. Observations from recent studies have accounted for the involvement of the gut–liver axis in the pathophysiological mechanism responsible for HCC.
Haripriya Gupta, Gi Soo Youn, Min Jea Shin, Ki Tae Suk   +3 more
openaire   +3 more sources

Serum steroid profiling of hepatocellular carcinoma associated with hyperadrenocorticism in dogs: A preliminary study

Frontiers in Veterinary Science, 2022
BackgroundHepatocellular carcinoma (HCC) is one of the most common primary liver tumors in humans and dogs. Excessive adrenocortical hormone exposure may cause steroid hepatopathy, which may develop into HCC.
Thandar Oo, Noboru Sasaki, Yoshinori Ikenaka, Takahiro Ichise, Noriyuki Nagata, Nozomu Yokoyama, Kazuyoshi Sasaoka, Keitaro Morishita, Kensuke Nakamura, Mitsuyoshi Takiguchi   +9 more
doaj   +1 more source

Mac‐2 Binding Protein Glycosylation Isomer (M2BPGi)–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi   +8 more
wiley   +1 more source

Comparative analysis of TP53 gene in Tupaia belangeri subspecies (Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis) and identification of mutations in spontaneous tumor cases

Animal Models and Experimental Medicine, EarlyView.
This study provides the first evidence of natural TP53 variation between tree shrew subspecies and identifies somatic TP53 mutations in spontaneous tree shrew sarcomas. The high structural and functional conservation of tree shrew p53 with humans supports its utility as a relevant model for TP53‐related cancer research.
Yingying Cao, Haibo Tang, Liang Liang, Jing Leng, Weijian Huang   +4 more
wiley   +1 more source

An update on hepatocarcinogenesis.

Hong Kong medical journal = Xianggang yi xue za zhi, 2009
Hepatocellular carcinoma is the most common cancer occurring in males in the world and has an annual incidence worldwide of 1 million. There are variations in its geographical distribution. It is the second most common cancer in Southeast Asia, including Hong Kong and ranks third among males in China.
Lai, CL, Lau, YN, Wu, PC
openaire   +2 more sources

Micro‐ and nanoplastics in gastrointestinal disorders: Mapping the translational gap between exposure, biomonitoring, and pathogenic mechanisms

BMEMat, EarlyView.
This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao, Yujie Luo, Chuanda Zhu, Yanwei Hu   +3 more
wiley   +1 more source

Pathogenicity and virulence of Hepatitis B virus

Virulence, 2022
Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are an estimated 296 million people in the world that are chronically infected by this virus, and many of them will develop severe liver diseases including hepatitis ...
Yu-Chen Chuang, Kuen-Nan Tsai, Jing-Hsiung James Ou   +2 more
doaj   +1 more source

Research progress in hepatitis B virus covalently closed circular DNA

Cancer Biology & Medicine, 2022
Hepatitis B virus (HBV) infections are a global public health issue. HBV covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs, is a key factor in the HBV replication cycle.
Xiaodong Zhang, Yufei Wang, Guang Yang
doaj   +1 more source

Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice

, 2012
Liver tumor, especially hepatocellular carcinoma (HCC), is closely associated with chronic inflammation. We previously showed that farnesoid X receptor knockout (FXR−/−) mice displayed chronic inflammation and developed spontaneous liver tumors when they
Yu, Hua, Guiyu Lou, Carl Van Ness, Zhou, Hong, Chao He, Zhang, Yunfeng, He, Chao, Wu, Jun, Hong Zhou, Lou, Guiyu, Ness, Carl Van, Meng, Zhipeng, Jun Wu, Hua Yu, Zhipeng Meng, Huang, Wendong, Xu, Rongzhen, Wendong Huang, Rongzhen Xu, Gan, Yichao, Xiaoqiong Wang, Wang, Xiaoqiong, Yunfeng Zhang, Yichao Gan   +23 more
core   +1 more source

Protective Effects of Defatted Sticky Rice Bran Extracts on the Early Stages of Hepatocarcinogenesis in Rats

Molecules, 2019
Use of natural products is one strategy to lessen cancer incidence. Rice bran, especially from colored rice, contains high antioxidant activity. Cancer chemopreventive effects of hydrophilic purple rice bran extract (PRBE) and white rice bran extract ...
Aphisit Dokkaew, Charatda Punvittayagul, Orapin Insuan, Pornngarm Limtrakul (Dejkriengkraikul), Rawiwan Wongpoomchai   +4 more
doaj   +1 more source