Results 51 to 60 of about 24,189 (241)

JAK/STAT signaling in hepatocellular carcinoma

Hepatic Oncology, 2020
Liver cancer is the second most lethal cancer in the world with limited treatment options. Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has had increasing global incidence over the past few years.
Justin Jit Hin Tang, Dexter Kai Hao Thng, Jhin Jieh Lim, Tan Boon Toh   +3 more
doaj   +1 more source

Impact of the introduction of direct-acting anti-viral drugs on hepatocarcinogenesis: a prospective serial follow-up MRI study [PDF]

, 2020
Background: We conducted a prospective study using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid–enhanced magnetic resonance imaging (Gd-EOB-MRI) to determine whether sustained virological response (SVR) by direct-acting anti-viral (DAA ...
Chayama, K, Hidenori Toyoda, Toyoda, H, Yasuda, S, Tada, T, Tanaka, J, Takashi Kumada, Kenji Takeshima, Kazuaki Chayama, Satoshi Yasuda, Johnson, PJ, Toshifumi Tada, Philip J Johnson, Ogawa, S, Kumada, T, Sadanobu Ogawa, Takeshima, K, Junko Tanaka   +17 more
core   +1 more source

Hepatitis B virus and Hepatocarcinogenesis

, 2008
Hepatitis B viral (HBV) infection is the commonest cause of hepatocellular carcinoma. HBV DNA is the most important predictor of hepatocarcinogenesis in HB surface antigen positive patients.
Faisal Azam, Anastasios Koulaouzidis
core   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Hepatocarcinogenesis: imaging-pathologic correlation

, 2011
Rapid advances in liver surgery, including liver transplantation, radiology, and pathology, have created a need for clinically relevant nomenclature for premalignant and early lesions of hepatocellular carcinoma (HCC).
박영년, 김명진
core   +1 more source

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

, 2022
The compressed file contains the CellBender filtered snRNA-seq data of the human samples used in the paper "Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis" (https://www.nature.com/articles/s41586-022-05289-6)
Ajay Nair (11993258)
core   +2 more sources

An inflammatory proposal for hepatocarcinogenesis [PDF]

Hepatology, 2012
Abstract Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory ...
Rachel I. Brody, Neil D. Theise, Roberto J. Groszmann, Yasuko Iwakiri, Tamar H. Taddei   +4 more
openaire   +2 more sources

Rare Inherited Cholestatic Disorders and Molecular Links to Hepatocarcinogenesis

Cells, 2022
Hepatocellular carcinoma (HCC) is the most common primary liver cancer affecting adults and the second most common primary liver cancer affecting children.
Rebecca Jeyaraj, Deirdre Kelly
doaj   +1 more source

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway

Cancer Medicine, 2022
Background & Aims Capsaicin, a functional component of chili pepper, possesses anti‐inflammatory, analgesic, and anti‐cancer properties. This study aimed to determine the property of capsaicin against hepatocarcinogenesis in vivo and investigate the role
Zhi‐Qin Xie, Hong‐Xia Li, Xiao‐Juan Hou, Mei‐Yuan Huang, Ze‐Min Zhu, Li‐Xin Wei, Cai‐Xi Tang   +6 more
doaj   +1 more source