Results 1 to 10 of about 541,993 (403)
Nature Communications, 2020 Due to their bacterial ancestry, many components of mitochondria share structural similarities with bacteria. Release of molecular danger signals from injured cell mitochondria (mitochondria-derived damage-associated molecular patterns, mito-DAMPs ...
Ping An, Michelle Lai, Yury V Popov
exaly +2 more sources
The hepatocyte clock and feeding control chronophysiology of multiple liver cell types
Science, 2020 The hepatocyte clock and food availability control gene expression and metabolism in nonhepatocytic cells in the liver. Keeping rhythm requires communication In mammals, daily cycles in physiology require the synchronized activity of circadian clocks in ...
Dongyin Guan, Yang Xiao, Wenxiang Hu
exaly +2 more sources
De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation
Nature, 2018 Transdifferentiation is a complete and stable change in cell identity that serves as an alternative to stem-cell-mediated organ regeneration. In adult mammals, findings of transdifferentiation have been limited to the replenishment of cells lost from ...
Simone N T Kurial +2 more
exaly +2 more sources
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis
Science Translational Medicine, 2018 Aberrant hepatocyte Notch activation is required for development of NASH-associated fibrosis, and Notch inhibition ameliorates obesity-induced liver disease.
Changyu Zhu, KyeongJin Kim, Xiaobo Wang
exaly +2 more sources
Hepatocyte transplantation [PDF]
Journal of Hepatology, 2004 Numerous laboratory studies have shown that hepatocyte transplantation may serve as an alternative to organ transplantation for patients with life-threatening liver disease. Because of the successes of experimental hepatocyte transplantation, institutions have attempted to use this therapy in the clinic for the treatment of a variety of hepatic ...
Ira J, Fox, Jayanta, Roy-Chowdhury
openaire +7 more sources
Theranostics, 2023 Rationale: Liver ischemia-reperfusion (LI/R) injury is characterized by two interconnected phases: local ischemia that causes hepatic cell damage to release damage-associated molecular pattern (DAMPs), and DAMPs that recruit immune cells to elicit ...
Shuya Du +9 more
semanticscholar +1 more source
Biological Effects of Aqueous Extract of Laurus noboilis L. Leaves on Some Histological and Immunological Parameters in Male Rat Liver Affected by Aluminum Chloride [PDF]
Archives of Razi Institute, 2021 The present current study aimed to assess the protective effect of the aqueous extract of Laurus noboilis L. leaves against the toxic effects of aluminum chloride on liver tissue.
N Marza Hamza +2 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 The liver is the most important metabolic hub of endo and xenobiotic compounds. Pre-clinical studies using rodents to evaluate the toxicity of new drugs and cosmetics may produce inconclusive results for predicting clinical outcomes in humans, moreover ...
Kayque Alves Telles-Silva +7 more
doaj +1 more source