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Hepatocyte transplantation [PDF]
Journal of Hepatology, 2004 Numerous laboratory studies have shown that hepatocyte transplantation may serve as an alternative to organ transplantation for patients with life-threatening liver disease. Because of the successes of experimental hepatocyte transplantation, institutions have attempted to use this therapy in the clinic for the treatment of a variety of hepatic ...
Ira J, Fox, Jayanta, Roy-Chowdhury
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Biological Effects of Aqueous Extract of Laurus noboilis L. Leaves on Some Histological and Immunological Parameters in Male Rat Liver Affected by Aluminum Chloride [PDF]
Archives of Razi Institute, 2021 The present current study aimed to assess the protective effect of the aqueous extract of Laurus noboilis L. leaves against the toxic effects of aluminum chloride on liver tissue.
N Marza Hamza +2 more
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Frontiers in Bioengineering and Biotechnology, 2022 The liver is the most important metabolic hub of endo and xenobiotic compounds. Pre-clinical studies using rodents to evaluate the toxicity of new drugs and cosmetics may produce inconclusive results for predicting clinical outcomes in humans, moreover ...
Kayque Alves Telles-Silva +7 more
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Regenerative Medicine of Liver: Promises, Advances and Challenges
Biomimetics, 2021 Liver tissue engineering is a rapidly developing field which combines the novel use of liver cells, appropriate biochemical factors, and engineering principles, in order to replace or regenerate damaged liver tissue or the organ.
Saiful Ali +4 more
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Cells, 2021 Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to modulate the production and function of insulin-like growth factor ...
Mari C. Vázquez-Borrego +2 more
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Hepatocyte Transplantation [PDF]
Journal of Clinical and Experimental Hepatology, 2011 Hepatocyte transplantation (HTx) has been developed for use in liver-based metabolic disorders and in acute liver failure. Worldwide, there are around 80 patients that have been transplanted with hepatocytes. Almost all reported studies prove feasibility and safety of the procedure with short- to medium-term success.
Ragai R, Mitry +2 more
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Liver Organoids: Updates on Disease Modeling and Biomedical Applications
Biology, 2021 Liver organoids are stem cell-derived 3D structures that are generated by liver differentiation signals in the presence of a supporting extracellular matrix. Liver organoids overcome low complexity grade of bidimensional culture and high costs of in vivo
Carmen Caiazza +2 more
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Cells, 2020 The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis.
Hye-Young Seo +7 more
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Toxicological Analysis of Hepatocytes Using FLIM Technique: In Vitro versus Ex Vivo Models
Cells, 2021 The search for new criteria indicating acute or chronic pathological processes resulting from exposure to toxic agents, testing of drugs for potential hepatotoxicity, and fundamental study of the mechanisms of hepatotoxicity at a molecular level still ...
Svetlana Rodimova +8 more
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Antioxidants, 2023 Hepatotoxicity or drug-induced liver injury (DILI) is a major safety issue in drug development as a primary reason for drug failure in clinical trials and the main cause for post-marketing regulatory measures like drug withdrawal.
Estela Villanueva-Badenas +2 more
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