Results 11 to 20 of about 541,993 (403)

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

Hepatology, 2010
Karim Si-Tayeb, Stephen Dalton, Stephen A Duncan   +2 more
exaly   +2 more sources

Regenerative Medicine of Liver: Promises, Advances and Challenges

Biomimetics, 2021
Liver tissue engineering is a rapidly developing field which combines the novel use of liver cells, appropriate biochemical factors, and engineering principles, in order to replace or regenerate damaged liver tissue or the organ.
Saiful Ali, Nasira Haque, Zohya Azhar, Morvarid Saeinasab, Farshid Sefat   +4 more
doaj   +1 more source

Towards Understanding the Direct and Indirect Actions of Growth Hormone in Controlling Hepatocyte Carbohydrate and Lipid Metabolism

Cells, 2021
Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to modulate the production and function of insulin-like growth factor ...
Mari C. Vázquez-Borrego, Mercedes del Rio-Moreno, Rhonda D. Kineman   +2 more
doaj   +1 more source

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

Nature Communications, 2021
IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte lipotoxicity.
Jinrui Dong, S. Viswanathan, E. Adami, B. Singh, S. Chothani, B. Ng, Wei-Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S. J. Ko, Shamini G Shekeran, J. Tan, S. Lim, Mao Wang, P. Lio, P. Yen, S. Schafer, S. Cook, A. Widjaja   +18 more
semanticscholar   +1 more source

Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]

, 2012
BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen, Fang, Yaping, He, Yuqi, Liu, Hui-Xin, Wan, Yu-Jui Yvonne, Zhan, Qi   +5 more
core   +11 more sources

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection [PDF]

, 2020
Bovine African Trypanosomosis is an infectious parasitic disease affecting livestock productivity and thereby impairing the economic development of Sub-Saharan Africa. The most important trypanosome species implicated is T.
Brys, Lea, De Baetselier, Patrick, De Trez, Carl, Korf, Hannelie, Magez, Stefan, Stijlemans, Benoit, Van Ginderachter, Jo A   +6 more
core   +1 more source

Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis

Science Translational Medicine, 2021
Increased Jagged1 in pericentral hepatocytes causes liver fibrosis in response to hepatocyte TLR4–NF-κB pathway activation in NASH. A ligand for Notch in NASH Notch activation is known to occur during the development of nonalcoholic steatohepatitis (NASH)
Junjie Yu, Changyu Zhu, Xiaobo Wang, KyeongJin Kim, Alberto Bartolomé, P. Dongiovanni, Katherine P. Yates, Luca Valenti, M. Carrer, T. Sadowski, L. Qiang, I. Tabas, J. Lavine, U. Pajvani   +13 more
semanticscholar   +1 more source

Hepatocyte Transplantation [PDF]

Journal of Clinical and Experimental Hepatology, 2011
Hepatocyte transplantation (HTx) has been developed for use in liver-based metabolic disorders and in acute liver failure. Worldwide, there are around 80 patients that have been transplanted with hepatocytes. Almost all reported studies prove feasibility and safety of the procedure with short- to medium-term success.
Ragai R, Mitry, Robin D, Hughes, Anil, Dhawan   +2 more
openaire   +2 more sources

Liver Organoids: Updates on Disease Modeling and Biomedical Applications

Biology, 2021
Liver organoids are stem cell-derived 3D structures that are generated by liver differentiation signals in the presence of a supporting extracellular matrix. Liver organoids overcome low complexity grade of bidimensional culture and high costs of in vivo
Carmen Caiazza, Silvia Parisi, Massimiliano Caiazzo   +2 more
doaj   +1 more source

Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor

Cells, 2020
The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis.
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Yu Na Kang, Jae Seok Hwang, Keun-Gyu Park, Mi Kyung Kim, Byoung Kuk Jang   +7 more
doaj   +1 more source