Results 21 to 30 of about 541,993 (403)

Toxicological Analysis of Hepatocytes Using FLIM Technique: In Vitro versus Ex Vivo Models

Cells, 2021
The search for new criteria indicating acute or chronic pathological processes resulting from exposure to toxic agents, testing of drugs for potential hepatotoxicity, and fundamental study of the mechanisms of hepatotoxicity at a molecular level still ...
Svetlana Rodimova, Vadim Elagin, Maria Karabut, Irina Koryakina, Alexander Timin, Vladimir Zagainov, Mikhail Zyuzin, Elena Zagaynova, Daria Kuznetsova   +8 more
doaj   +1 more source

IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis.

Gastroenterology, 2020
BACKGROUND & AIMS Endoplasmic reticulum to nucleus signaling 1 (ERN1, also called IRE1A) is a sensor of the unfolded protein response that is activated in livers of patients with nonalcoholic steatohepatitis (NASH).
Debanjali Dasgupta, Yasuhiko Nakao, Amy Mauer, Jill Thompson, Tejasav S. Sehrawat, Chieh-Yu Liao, A. Krishnan, F. Lucien, Qianqian Guo, Mengfei Liu, Fei Xue, Masanori Fukushima, Tomohiro Katsumi, Aditya Bansal, M. Pandey, Jessica L. Maiers, T. DeGrado, Samar H. Ibrahim, A. Revzin, K. Pavelko, M. Barry, R. Kaufman, H. Malhi   +22 more
semanticscholar   +1 more source

Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages

Antioxidants, 2023
Hepatotoxicity or drug-induced liver injury (DILI) is a major safety issue in drug development as a primary reason for drug failure in clinical trials and the main cause for post-marketing regulatory measures like drug withdrawal.
Estela Villanueva-Badenas, M. Teresa Donato, Laia Tolosa   +2 more
doaj   +1 more source

Extracellular Vesicles From Hepatocytes Are Therapeutic for Toxin-Mediated Fibrosis and Gene Expression in the Liver

Frontiers in Cell and Developmental Biology, 2020
Extracellular vesicles (EVs) are nano-sized membrane-limited organelles that are liberated from their producer cells, traverse the intercellular space, and may interact with other cells resulting in the uptake of the EV molecular payload by the recipient
Xinlei Li, Ruju Chen, Sherri Kemper, David R. Brigstock, David R. Brigstock   +4 more
doaj   +1 more source

Hepatoprotective Effect of Solanum melongena/Eggplant against Acute Hepatitis

Althea Medical Journal, 2015
Background: Hepatitis is a liver inflammation that can be acute or chronic and may cause damage to hepatocytes such as necrosis.. Hepatocyte necrosis can be inhibited by antioxidants such as flavonoids found in Solanum melongena fruit.
Nabhan Komara, Herri S. Sastramihardja, Afiati   +2 more
doaj   +1 more source

Increased Levels of Phosphorylated ERK Induce CTGF Expression in Autophagy-Deficient Mouse Hepatocytes

Cells, 2022
Autophagy performs essential cell functions in the liver through an intracellular lysosomal degradation process. Several studies have reported that autophagy deficiency can lead to liver injury, including hepatic fibrosis; however, the mechanisms ...
Hye-Young Seo, So-Hee Lee, Eugene Han, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang   +5 more
doaj   +1 more source

Hepatocyte transplantation

Revista Española de Enfermedades Digestivas, 2019
We have read with great interest the study by Vera MC et al. on the intrasplenic transplantation of hepatocytes from donors receiving the carcinogenic drugs diethylnitrosamine (DEN) and 2-actylaminofluorene (2-AAF). The most important conclusion of the study is that there were no signs of tumor progression in the recipient liver at seven and 60 days ...
Javier A, Cienfuegos, Fernando, Rotellar, Víctor, Valenti   +2 more
openaire   +2 more sources

NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte

eLife, 2019
Hepatocellular carcinoma (HCC) is a deadly human cancer associated with chronic inflammation. The cytosolic pathogen sensor NLRP12 has emerged as a negative regulator of inflammation, but its role in HCC is unknown.
SM Nashir Udden, Youn-Tae Kwak, Victoria Godfrey, Md Abdul Wadud Khan, Shahanshah Khan, Nicolas Loof, Lan Peng, Hao Zhu, Hasan Zaki   +8 more
doaj   +1 more source

Dynamics of Hepatitis B Virus Covalently Closed Circular DNA: A Mini-Review

Microorganisms, 2023
Eradication of cccDNA is an ideal goal of chronic hepatitis B (CHB) therapy. Understanding the changes in the cccDNA pool during therapy provides a basis for developing CHB treatment strategies.
Jie-Li Hu, Ai-Long Huang
doaj   +1 more source

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources