Results 31 to 40 of about 541,993 (403)

Isolated Hepatocytes versus Hepatocyte Spheroids: In Vitro Culture of Rat Hepatocytes [PDF]

Cell Transplantation, 2005
The use of hepatocytes that express liver-specific functions to develop an artificial liver is promising. Unfortunately, the loss of specialized liver functions (dedifferentiation) is still a major problem. Different techniques, such as collagen entrapment, spherical multicellular aggregates (spheroids), and coculture of hepatocytes with extracellular
Giovanni Ambrosino, Stefano M. M. Basso, Sergio Varotto, Enrico Zardi, Antonio Picardi, Davide F. D'amico   +5 more
openaire   +4 more sources

The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver

Journal of Lipid Research, 2005
The ABC transporter ABCG1 (ATP binding cassette transporter G1), expressed in macrophages, liver, and other tissues, has been implicated in the efflux of cholesterol to high density lipoprotein.
Steven L. Sabol, H. Bryan Brewer, Jr., Silvia Santamarina-Fojo   +2 more
doaj   +1 more source

Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

Gut, 2020
Objective Lipotoxic hepatocyte injury is a primary event in non-alcoholic steatohepatitis (NASH), but the mechanisms of lipotoxicity are not fully defined.
E. Koh, Ji Eun Yoon, M. Ko, Jaechan Leem, Ji-Young Yun, Chung Hwan Hong, Y. Cho, Seung Eun Lee, J. E. Jang, J. Baek, H. Yoo, S. Kim, C. Sung, Joon Seo Lim, W. Jeong, S. Back, In-Jeoung Baek, S. Torres, E. Solsona-Vilarrasa, Laura Conde de la Rosa, C. Garcia-Ruiz, A. Feldstein, J. Fernández-Checa, Ki-Up Lee   +23 more
semanticscholar   +1 more source

Human iPS Cell–based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B

Cell Transplantation, 2018
Instead of liver transplantation or liver-directed gene therapy, genetic liver diseases are expected to be treated effectively using liver tissue engineering technology.
Ryota Okamoto, Kazuo Takayama, Naoki Akita, Yasuhito Nagamoto, Daiki Hosokawa, Shunsuke Iizuka, Fuminori Sakurai, Hiroshi Suemizu, Kazuo Ohashi, Hiroyuki Mizuguchi   +9 more
doaj   +1 more source

Hepatic Nampt Deficiency Aggravates Dyslipidemia and Fatty Liver in High Fat Diet Fed Mice

Cells, 2023
Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis.
Dao-Xin Wang, Sheng-Li Qing, Zhu-Wei Miao, Heng-Yu Luo, Jia-Sheng Tian, Xiu-Ping Zhang, Shu-Na Wang, Tian-Guang Zhang, Chao-Yu Miao   +8 more
doaj   +1 more source

Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]

, 2018
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core   +1 more source

Adipocytes as lipid sensors of oleic acid transport through a functional Caco-2/HT29-MTX intestinal barrier

Adipocyte, 2019
Adipose tissue function in the regulation of lipemia is highly dependent on intestinal absorption of nutrients. Therefore the aim of the present study was the development and validation of an in vitro multiculture model allowing to measure intestinal ...
Emmanuelle Berger, Alain Géloën
doaj   +1 more source

Structured Illumination Microscopy of Mitochondrial in Mouse Hepatocytes with an Improved Image Reconstruction Algorithm

Micromachines, 2023
In this paper, a structured illumination microscopy (SIM) image reconstruction algorithm combined with notch function (N-SIM) is proposed. This method suppresses the defocus signal in the imaging process by processing the low-frequency signal of the ...
Kai Hu, Xuejuan Hu, Ting He, Jingxin Liu, Shiqian Liu, Jiaming Zhang, Yadan Tan, Xiaokun Yang, Hengliang Wang, Yifei Liang, Jianze Ye   +10 more
doaj   +1 more source

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

Scientific Reports, 2016
Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to study using current in vitro models such as primary human hepatocyte (PHH) monolayer cultures, as their rapid de-differentiation restricts their usefulness ...
Catherine C. Bell, D. Hendriks, Sabrina M. L. Moro, Ewa C. S. Ellis, Joanne Walsh, A. Renblom, Lisa Fredriksson Puigvert, A. Dankers, F. Jacobs, J. Snoeys, R. Sison-Young, R. Jenkins, Å. Nordling, S. Mkrtchian, B. K. Park, N. Kitteringham, C. Goldring, V. M. Lauschke, M. Ingelman-Sundberg   +18 more
semanticscholar   +1 more source

Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis.

Journal of Clinical Investigation, 2020
Neutrophil infiltration around lipotoxic hepatocytes is a hallmark of nonalcoholic steatohepatitis (NASH); however, how these two types of cells communicate remain obscure.
Yong He, R. Rodrigues, Xiaolin Wang, Wonhyo Seo, Jing Ma, Seonghwan Hwang, Yaojie Fu, Eszter Trojnar, C. Mátyás, Suxian Zhao, Ruixue Ren, D. Feng, P. Pacher, G. Kunos, B. Gao   +14 more
semanticscholar   +1 more source