Results 21 to 30 of about 79,825 (316)
Hepatocyte nuclear factor 1 alpha activates promoter 1 of the human insulin-like growth factor I gene via two distinct binding sites. [PDF]
Molecular Endocrinology, 1995 Expression of the human insulin-like growth factor I (hIGF-I) gene is regulated in a tissue- and developmental stage-specific manner. The hIGF-I gene has two promoters, P1 and P2. P1 is the more active promoter by far in adult liver, the main endocrine source of IGF-I.
Linda A. Nolten +2 more
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Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
Cell Reports, 2023 Summary: The nuclear receptor liver receptor homolog-1 (LRH-1) has been shown to promote apoptosis resistance in various tissues and disease contexts; however, its role in liver cell death remains unexplored.
Rebekka Lambrecht +9 more
doaj +1 more source
Hepatocyte nuclear factor 1-alpha mutation in normal glucose-tolerant subjects and early-onset type 2 diabetic patients [PDF]
The Korean journal of internal medicine, 2008 The prevalence of diabetes in Korea is reported to be approximately 10%, but cases of maturity-onset diabetes of the young (MODY) are rare in Korea. A diagnostic technique for autosomal dominant MODY is being actively sought. In this regard, we used a DNA chip to investigate the frequency of mutations of the MODY3 gene (hepatocyte nuclear factor-1alpha)
Dong Mee Lim, Nam Huh, Keun Yong Park
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, 1995 Pterin-4a-carbinolamine dehydratase/dimerization cofactor for hepatocyte nuclear factor-1α is a protein with two different functions. We have overexpressed and purified the human wild-type protein, and its Cys81Ser and Cys81Arg mutants. The Cys81Arg mutant has been proposed to be causative in a hyperphenylalaninaemic patient [Citron, B. A., Kaufman, S.,
Sandra Köster +6 more
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Journal of Biological Chemistry, 1994 Elevated levels of lipoprotein(a) (Lp(a)) in the plasma are a risk factor for coronary artery disease and stroke. Plasma Lp(a) concentrations are highly heritable and predominantly determined by the liver-specific apolipoprotein(a) (apo(a)) gene.
David P. Wade +2 more
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A Novel HNF4A Mutation Causing Three Phenotypic Forms of Glucose Dysregulation in a Family
Frontiers in Pediatrics, 2020 Maturity-onset diabetes of the young (MODY) classically describes dominantly inherited forms of monogenic diabetes diagnosed before 25 years of age due to pancreatic β-cell dysfunction.
Suresh Chandran +13 more
doaj +1 more source
Hepatocyte Nuclear Factor-1α Gene Mutations and Diabetes in Norway [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2003 Mutations in the hepatocyte nuclear factor (HNF)-1 alpha gene cause maturity-onset diabetes of the young (MODY), type 3. To estimate the prevalence of MODY3 in Norwegian diabetic pedigrees, we screened a total of 130 families for HNF-1 alpha mutations; 42 families with clinical MODY, 75 with suspected MODY, and 13 pedigrees with multiplex type 1 ...
Lise, Bjørkhaug +5 more
openaire +2 more sources
Journal of Biological Chemistry, 1994 Hepatocyte nuclear factor-1 alpha (HNF-1 alpha) and HNF-1 beta are transcription factors that contain a divergent homeodomain, bind to DNA as homo- or heterodimers, and act to regulate transcription of many genes that are expressed primarily in liver.
Gary D. Wu +3 more
openalex +3 more sources
Development and characterization of a new human hepatic cell line [PDF]
, 2015 The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert +6 more
core +4 more sources