Results 31 to 40 of about 334,700 (354)

Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]

, 2012
BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen, Fang, Yaping, He, Yuqi, Liu, Hui-Xin, Wan, Yu-Jui Yvonne, Zhan, Qi   +5 more
core   +12 more sources

A Novel HNF4A Mutation Causing Three Phenotypic Forms of Glucose Dysregulation in a Family

Frontiers in Pediatrics, 2020
Maturity-onset diabetes of the young (MODY) classically describes dominantly inherited forms of monogenic diabetes diagnosed before 25 years of age due to pancreatic β-cell dysfunction.
Suresh Chandran, Suresh Chandran, Suresh Chandran, Suresh Chandran, Victor Samuel Rajadurai, Victor Samuel Rajadurai, Victor Samuel Rajadurai, Victor Samuel Rajadurai, Wai Han Hoi, Sarah E. Flanagan, Khalid Hussain, Fabian Yap, Fabian Yap, Fabian Yap   +13 more
doaj   +1 more source

The Protective Effect and Mechanism of a Phytochemical Extract from the Wild Vegetable Shutou (Crateva unilocularis Buch.) against Acetaminophen-Induced Liver Injury in Mice

Foods, 2023
Acetaminophen (APAP) abuse is a common public health problem which can cause severe liver damage. However, strategies for dealing with this situation safely and effectively are very limited. The goal of the current work was to evaluate the protection and
Meimei Shan, Qian Ma, Yilin Sun, Fengyi Gao, Shengbao Cai   +4 more
doaj   +1 more source

Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

Diabetology & Metabolic Syndrome, 2022
Background Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess the association of HNF1A gene and haplotypes with the metabolic syndrome (MetS) and ...
Hamza Dallali, Meriem Hechmi, Imane Morjane, Sahar Elouej, Haifa Jmel, Yosra Ben Halima, Abdelmajid Abid, Afef Bahlous, Abdelhamid Barakat, Henda Jamoussi, Sonia Abdelhak, Rym Kefi   +11 more
doaj   +1 more source

The Use of Cell-penetrating Peptide for Delivery of Recombinant Transcription Factor DNA into Primary Human Fibroblast

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Reprogrammed cell therapy has not been applied for clinical purposes due to the malignancy issue. The aim of this study was to design the recombinant vector of the transcription factors and analyze the effectiveness of cell-penetrating ...
Melinda Remelia, Budiman Bela, Silvia Tri Widyaningtyas, Radiana Dhewayani Antarianto, Nuzli Fahdia Mazfufah, Jeanne Adiwinata Pawitan   +5 more
doaj   +1 more source

Development and characterization of a new human hepatic cell line [PDF]

, 2015
The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert, De Craene, Bram, De Kock, Joey, Ramboer, Eva, Rogiers, Vera, Vanhaecke, Tamara, Vinken, Mathieu   +6 more
core   +4 more sources

Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma

Case Reports in Gastroenterology, 2020
Hepatocellular adenomas (HCA) are rare benign tumors of the liver, occurring predominantly in females using oral contraceptives. Our case describes a 66-year-old woman presenting with a palpable mass in her upper abdomen.
Joris T. Hepkema, Floris B. Poelmann, Annette S.H. Gouw, Robbert J. de Haas, Evelien W. Duiker, Hans Blokzijl, Joost M. Klaase   +6 more
doaj   +1 more source

Mutations in transcription factor as rare causes of diabetes in pregnancy

Сахарный диабет, 2019
MODY1 and MODY3 represent rare causes of diabetes in pregnancy. Establishing a molecular diagnosis of MODY1 or MODY3 during pregnancy may be important for minimizing risk of perinatal complications and for improving glycemic control after pregnancy.
Natalia A. Zubkova, Fatima F. Burumkulova, Vasily A. Petrukhin, Margarita A. Plechanova, Anton E. Panov, Evgeny V. Vasilyev, Vasily M. Petrov, Nina A. Makretskaya, Anatoliy N. Tyulpakov   +8 more
doaj   +1 more source

HNF4A (Hepatocyte Nuclear Factor 4 alpha) [PDF]

, 2017
Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (Nuclear Receptor Subfamily 2, group A, member 1) is a member of the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. The encoded protein controls the expression of
Banerjee, Sreeparna, Tunçer, Sinem
core   +1 more source

Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease. [PDF]

Cell Death Discov
RelA, also known as nuclear factor kappa B p65, plays a crucial role in the pathogenesis of various liver diseases. However, the specific role of RelA in hepatocytes during the progression of metabolic dysfunction-associated steatotic liver disease ...
He Y, Jiang J, Ou L, Chen Y, Abudukeremu A, Chen G, Zhong W, Jiang Z, Nuermaimaiti N, Guan Y.   +9 more
europepmc   +2 more sources