A novel technique for selective NF-kappa B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. [PDF]
, 2009 Background and aims: The transcription factor nuclear factor kappa B (NF-kB) has risen as a promising target for anti-inflammatory therapeutics. In the liver, however, NFkB inhibition mediates both damaging and protective effects.
A. Hartkorn +11 more
core +1 more source
Frontiers in Pharmacology, 2017 Hepatocyte nuclear factor 1-alpha (HNF1A) is a liver-enriched transcription factor that plays a key role in many aspects of hepatic functions including detoxification processes.
Adrien Labriet +15 more
doaj +1 more source
TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases [PDF]
, 2019 The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process in the liver, where it contributes also to organ inflammation following several ...
Amicone, Laura +8 more
core +1 more source
Annals of Saudi Medicine, 2014 BACKGROUND AND OBJECTIVES: The prevalence of maturity-onset diabetes of the young (MODY) in Saudi population remains unknown, and data on molecular etiology of this condition is limited.
Sarar Mohamed +4 more
doaj +1 more source
Effect of Urtica dioica L extract on quantitative morphometric alterations of liver parenchymal cells in STZ diabetic rats [PDF]
, 2009 Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative ...
Farsi, M.M. +2 more
core +1 more source
BMC Medicine, 2021 Background Serum transferrin levels represent an independent predictor of mortality in patients with liver failure. Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of hepatocyte functions.
Nurdan Guldiken +17 more
doaj +1 more source
RIPK1 protects from TNF-α-mediated liver damage during hepatitis [PDF]
, 2016 Cell death of hepatocytes is a prominent characteristic in the pathogenesis of liver disease, while hepatolysis is a starting point of inflammation in hepatitis and loss of hepatic function.
Bertin, John +11 more
core +1 more source
Hepatocyte Nuclear Factor 1α: A Key Mediator of the Effect of Bile Acids on Gene Expression [PDF]
Hepatology, 2003 Bile acids regulate the expression of genes involved in cholesterol homeostasis. They are ligands of the farnesoid X receptor, which induces small heterodimer partner (SHP)–1, a transcriptional repressor of bile acid synthetic enzymes.
Jung Diana, Kullak-Ublick Gerd A
openaire +3 more sources
Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins. [PDF]
PLoS ONE, 2016 Refined methods for maintaining specific functions of isolated hepatocytes under xeno-free and chemical defined conditions is of great importance for the development of hepatocyte research and regenerative therapy.
Masaaki Watanabe +6 more
doaj +1 more source
Searching for "monogenic diabetes" in dogs using a candidate gene approach [PDF]
, 2014 BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and ...
Catchpole, B +7 more
core +2 more sources