Activation of p53 After Irradiation Impairs the Regenerative Capacity of the Mouse Liver
Hepatology Communications, 2022 Radiation therapy is one of the treatment methods for hepatocellular carcinoma. However, radiation tolerance of the liver is low, and the detailed effect of radiation on liver regeneration has not been clarified.
Makiko Urabe +14 more
doaj +1 more source
The regulatory landscape of retinoblastoma: a pathway analysis perspective
Royal Society Open Science, 2022 Retinoblastoma (Rb) is a rare intraocular tumour in early childhood, with an approximate incidence of 1 in 18 000 live births. Experimental studies for Rb are complex due to the challenges associated with obtaining a normal retina to contrast with ...
Laura Gómez-Romero +4 more
doaj +1 more source
TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases [PDF]
, 2019 The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process in the liver, where it contributes also to organ inflammation following several ...
Amicone, Laura +8 more
core +1 more source
Scalar and vector form factors of the in-medium nucleon [PDF]
Phys.Lett. B575 (2003) 4-10, 2003 Using the quark-meson coupling model, we calculate the form factors at sigma- and omega-nucleon strong-interaction vertices in nuclear matter. The Peierls-Yoccoz projection technique is used to take account of center of mass and recoil corrections. We also apply the Lorentz contraction to the internal quark wave function.
arxiv +1 more source
Malignant Transformation of an HNF1a-Inactivated Hepatocellular Adenoma to Hepatocellular Carcinoma
Case Reports in Gastroenterology, 2020 Hepatocellular adenomas (HCA) are rare benign tumors of the liver, occurring predominantly in females using oral contraceptives. Our case describes a 66-year-old woman presenting with a palpable mass in her upper abdomen.
Joris T. Hepkema +6 more
doaj +1 more source
Human Mutation, 2006 Maturity‐onset diabetes of the young (MODY) is a monogenic form of diabetes mellitus characterized by autosomal dominant inheritance, early age of onset (often
S. Ellard, K. Colclough
semanticscholar +1 more source
The effect of estrogen and tamoxifen on hepatocyte proliferation in Vivo and in Vitro [PDF]
, 1989 We have previously shown that changes in estrogen‐hepatocyte interaction occur during liver regeneration. Following 70% hepatectomy, estrogen levels in the blood were elevated, the number of estrogen receptors in the liver was increased and there was an ...
Ambrosino, G +10 more
core +1 more source
Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolism. [PDF]
PLoS ONE, 2012 Lipin 1 is a bifunctional protein that serves as a metabolic enzyme in the triglyceride synthesis pathway and regulates gene expression through direct protein-protein interactions with DNA-bound transcription factors in liver. Herein, we demonstrate that
Zhouji Chen +3 more
doaj +1 more source
Journal of Biological Chemistry, 2002 Sucrase-isomaltase (SI), an intestine-specific gene, is induced in the differentiated small intestinal villous epithelium during the suckling-weaning transition in mice.
F. Boudreau +9 more
semanticscholar +1 more source
An epistatic mini-circuitry between the transcription factors Snail and HNF4a controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs [PDF]
, 2012 Preservation of the epithelial state involves the stable repression of EMT program while maintenance of the stem compartment requires the inhibition of differentiation processes.
AMICONE, Laura +8 more
core +1 more source