Results 161 to 170 of about 233,279 (266)

Insulin increases expression of cannabinoid receptor 1 by suppressing lysosomal degradation via ERK signaling pathway. [PDF]

Int J Med Sci
Liu SY, Ting CH, Hwang GS, Chen CW, Chen LK, Ho PH, Lee PH, Wu GL, Yin WH, Wu LY, Seow KM, Lin HF, Juan CC.   +12 more
europepmc   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

TGFβ activity stabilizes ACC1 to increase de novo lipogenesis in metabolic liver disease. [PDF]

Mol Metab
Mayfield B, Yagashita Y, Kang J, Zhu C, Mira S, Kendall TJ, Sun Q, Meincke ME, Raphael D, Li M, Chen S, Cullen H, Meadows SM, Berchowitz LE, Carrer M, Fallowfield JA, Schwabe RF, Valenti L, Pajvani UB.   +18 more
europepmc   +1 more source

Indole‐3‐Acetic Acid Protects Bovine Hepatocytes Against Palmitic Acid‐Induced Lipid Accumulation and ER Stress Through SIRT3

Animal Research and One Health, EarlyView.
Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi, Chenchen Zhao, Guiying Li, Jinxia Li, Menglin Liu, Fanrong Kong, Enzhu Li, Jie Gao, Wenqi Liao, Akos Kenez, Wenwen Gao, Yuxiang Song, Xiliang Du, Guowen Liu, Xinwei Li, Lin Lei   +15 more
wiley   +1 more source

Inhibition of STING alleviates lipotoxicity in viral-infected primary mouse hepatocytes and viral hepatitis-associated liver damage. [PDF]

Front Pharmacol
Zhang Y, Li Y, Qin Y, Liang S, Liu K, Liang X.   +5 more
europepmc   +1 more source

Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics

Animal Research and One Health, EarlyView.
Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley   +1 more source

Influence of farnesoid X receptor (<i>FXR</i>) on lipid metabolism in calf hepatocytes exposed to high fatty acid levels. [PDF]

Front Vet Sci
Jia B, Tian Y, Gao C, Chang Y, Zhang Z, Song Y, Xia C, Qu Y, Yang W.   +8 more
europepmc   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source

Residue 188 of the Hexon protein governs FAdV-4 pathogenicity by activating PINK1/Parkin-mediated mitophagy. [PDF]

Vet Res
Wang B, Qiao Q, Yang P, Xu M, Qiu L, Zhu Y, Xiang M, Cong Y, Yang D, Li J, Yu K, Zhao J.   +11 more
europepmc   +1 more source

Pathophysiological Mechanisms of Emaciation Syndrome in Plectropomus leopardus: Insights From Histology and Transcriptomics

Animal Research and One Health, EarlyView.
Integrated phenotypic, histological, transcriptomic, and validation analyses reveal that emaciation syndrome in Plectropomus leopardus is associated with intestinal structural damage, hepatic metabolic remodeling, and muscle protein degradation, highlighting coordinated multi‐tissue alterations underlying disease progression.
Zhihao Zhang, Bo Wang, Mengya Wang, Haizhan Tang, Mingjian Liu, Da Zheng, Zhongyi Zhai, Jiahang Li, Jinyang Xie, Chaofan Jin, Jingjie Hu, Zhenmin Bao   +11 more
wiley   +1 more source