Results 41 to 50 of about 56,507 (292)

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

A Histopathological, Immunohistochemical and Biochemical Investigation on the in vitro Antioxidant, Myeloprotective, Hematoprotective and Hepatoprotective Effects of Hypericum triquetrifolium Seed Extract Against Cyclophosphamide-Induced Toxicity

Brazilian Archives of Biology and Technology
The aim of this study was to investigate in vitro antioxidant properties and in vivo protective effects of the methanol extract of the Hypericum triquetrifolium Turra (HT) seed against acute hepatotoxicity, myelotoxicity and hematotoxicity in rats ...
Songul Cetik Yildiz, Cumali Keskin, Varol Sahintürk, Adnan Ayhanci   +3 more
doaj   +1 more source

Hepatoprotective Effect of Kaempferol—A Review

Molecules
Liver diseases, including chronic inflammation and related metabolic dysfunction-associated steatotic liver disease (MASLD), fibrosis and cirrhosis remain a growing global health burden. Currently, available pharmacotherapy for liver dysfunction has limited efficacy.
Przemysław Niziński, Anna Krajewska, Tomasz Oniszczuk, Beata Polak, Anna Oniszczuk   +4 more
openaire   +3 more sources

Evaluation of Anti-Inflammatory and Hepatoprotective Potency of a Selected Medicinal Plant [PDF]

, 2010
Not ...
Baravalia, Yogesh K.
core  

Hepatoprotective Properties of Starflowers from an Annual Herb, Borago officinalis L. (Boraginaceae): Hepatoprotective profile of Borage

, 2022
Traditionally, the decoction of leaves, flowers and stems of Borago officinalis was widely used in the treatment of liver diseases. The present work is aimed to assess the hepatoprotective properties of selected ethanolic fractions of Borago officinalis ...
Annam, Satya Sowbhagya Priya, Hieu, Ho Viet, Polimati, Haritha, Manthena, Sanjay Samanth   +3 more
core   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

The efficacy of hepatic protectors in patients having chronic hepatitis

Бюллетень сибирской медицины, 2008
The purpose of the present work was the study of new hepatic protectors liproksol influence in the chronic hepatitis viral and alcohol etiology in comparison of carsil effect. 69 patients having chronic hepatitis were include in the investigation.
E. I. Beloborodova, A. I. Vengerovsky, I. K. Livshits, Ye. V. Beloborodova, V. A. Burkovskaya, D. I. Kuzmenko   +5 more
doaj   +1 more source

Hepatoprotective Herbs, Avicenna Viewpoint [PDF]

Iranian Red Crescent Medical Journal, 2014
Liver injury or dysfunction is considered as a serious health problem. The available synthetic drugs to treat liver disorders are expensive and cause further damage. Hence, hepatoprotective effects of some herbal drugs have been investigated, and one of the methods to choose herbs in order to study their biological effects is to search in ancient ...
Shamsi-Baghbanan, Hamid, Sharifian, Afsaneh, Esmaeili, Somayeh, Minaei, Bagher   +3 more
openaire   +2 more sources

Hepatoprotective properties of Gentiana SPP: Against non-alcoholic fatty liver disease (NAFLD) [PDF]

, 2018
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterised by the accumulation of fat in the liver. It is estimated that 33 % of the UK population have NAFLD with 2-5 % progressing to non-alcoholic steatohepatitis (NASH).
Boateng, A.
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source