Results 31 to 40 of about 2,189 (194)

Insights into the Antimicrobial Properties of Hepcidins: Advantages and Drawbacks as Potential Therapeutic Agents

open access: yesMolecules, 2015
The increasing frequency of multi-drug resistant microorganisms has driven research into alternative therapeutic strategies. In this respect, natural antimicrobial peptides (AMPs) hold much promise as candidates for the development of novel antibiotics ...
Lisa Lombardi   +3 more
doaj   +1 more source

Hepcidin and Host Defense against Infectious Diseases. [PDF]

open access: yes, 2015
Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.
Ganz, Tomas   +3 more
core   +1 more source

Urine hepcidin, netrin-1, neutrophil gelatinase-associated lipocalin and C-C motif chemokine ligand 2 levels in multicystic dysplastic kidney

open access: yesBrazilian Journal of Nephrology, 2020
Introduction: Glomerular hyperfiltration may lead to proteinuria and chronic kidney disease in unilateral multicystic dysplastic kidney (MCDK). We aimed to investigate the urine neutrophil-gelatinase-associated lipocalin (NGAL), netrin-1, hepcidin, and C-
Nuran Cetin   +2 more
doaj   +2 more sources

Antimicrobial Peptides as Mediators of Innate Immunity in Teleosts

open access: yesBiology, 2015
Antimicrobial peptides (AMPs) have been identified throughout the metazoa suggesting their evolutionarily conserved nature and their presence in teleosts is no exception. AMPs are short (18–46 amino acids), usually cationic, amphipathic peptides.
Barbara A. Katzenback
doaj   +1 more source

Teleost Piscidins—In Silico Perspective of Natural Peptide Antibiotics from Marine Sources

open access: yesAntibiotics, 2023
Fish, like all other animals, are exposed to constant contact with microbes, both on their skin and on the surfaces of their respiratory and digestive systems. Fish have a system of non-specific immune responses that provides them with initial protection
Patricia Asensio-Calavia   +5 more
doaj   +1 more source

Human Antimicrobial Peptides as Therapeutics for Viral Infections

open access: yesViruses, 2019
Successful in vivo infection following pathogen entry requires the evasion and subversion of multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune pathways upregulated during infection by multiple pathogens, in ...
Aslaa Ahmed   +4 more
doaj   +1 more source

Hepcidin: inflammation versus hypoxia [PDF]

open access: yesSleep and Breathing, 2014
The finding of periodic leg movements (PLM) during polysomnographic recordings is a relatively common phenomenon. PLM is associated with a variety of sleep disorders [1, 2] and other diseases. An association between obstructive sleep apnea (OSA) and PLM [3–5] has been clearly established.
F, del Campo, C, Zamarrón
openaire   +2 more sources

Identification of Antimicrobial Peptide Genes in Black Rockfish Sebastes schlegelii and Their Responsive Mechanisms to Edwardsiella tarda Infection

open access: yesBiology, 2021
The black rockfish, Sebastes schlegelii, is a typical viviparous teleost, which belongs to the family Scorpaenidae. Due to its high economic and ecological values, S. schlegelii has been widely cultured in East Asian countries.
Min Zhang   +6 more
doaj   +1 more source

Molecular characterization and expression analysis of a hepcidin gene from rice field eel (Monopterus albus) [PDF]

open access: yes, 2013
Hepcidin is a cysteine-rich, dual-function peptide with antimicrobial activity that plays crucial roles in iron homeostasis. A few hepcidin-like genes have been isolated from teleost. Here, we have identified a hepcidin-like gene from rice field eel (RFE)
Li, CP, Li, W, Liu, CD, Sun, WX, Tang, F
core   +2 more sources

Hepcidin in hepatocellular carcinoma

open access: yesBritish Journal of Cancer, 2022
AbstractHepatocellular carcinoma (HCC) is one of the most common reasons for cancer-related deaths. Excess iron increases HCC risk. Inevitably, hepcidin, the iron hormone that maintains systemic iron homoeostasis is involved in HCC pathology. Distinct from other cancers that show high hepcidin expression, HCC patients can show low hepcidin levels. Thus,
Jonathan H. Joachim, Kosha J. Mehta
openaire   +5 more sources

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