Results 171 to 180 of about 16,515 (221)

Hereditary Nonpolyposis Colorectal Cancer

Scandinavian Journal of Gastroenterology, 1994
(1994). Hereditary Nonpolyposis Colorectal Cancer. Scandinavian Journal of Gastroenterology: Vol. 29, No. 8, pp. 673-677.
J P, Mecklin, L B, Svendsen, P, Peltomäki, H F, Vasen   +3 more
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Identifying Hereditary Nonpolyposis Colorectal Cancer

New England Journal of Medicine, 1998
The recent discovery of the genetic basis of certain familial aggregations of colorectal cancer validated 90 years of clinical observation suggesting that such aggregations are hereditary.1 It also...
H T, Lynch, T C, Smyrk
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Hereditary Nonpolyposis Colorectal Cancer

2007
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant colon cancer syndrome. The first description of a cancer-prone family with HNPCC dates back to the late 1800s.1 However, it was not until the work of Lynch in the 1970s that a more complete clinical picture of this disorder began to emerge.2,3 The diagnosis of HNPCC has, until ...
Erik C. Thorland, Stephen N. Thibodeau
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Hyperplastic Polyps in Hereditary Nonpolyposis Colorectal Cancer

American Journal of Gastroenterology, 2003
Hereditary nonpolyposis colorectal cancer (HNPCC) is a genetic syndrome caused by germline mutations in DNA mismatch repair (MMR) genes, in particular hMLH1, hMSH2, and hMSH6. Dysfunction of MMR genes leads to loss of MMR protein expression and to microsatellite instability (MSI).
Rijcken, FEM, Van der Sluis, T, Hollema, H, Kleibeuker, JH   +3 more
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Hereditary Nonpolyposis Colon Cancer

2009
Colorectal cancer affects 148,300 patients in the United States annually (72,600 males and 75,700 females) causing 56,600 deaths each year. Those patients who have two or more first-and/or second-degree relatives with colorectal cancer have a potentially definable inheritable disorder.
David E. Beck, Patricia L. Roberts, John L. Rombeau, Michael J. Stamos, Steven D. Wexner   +4 more
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Genetic testing for hereditary nonpolyposis colorectal cancer

Current Opinion in Gastroenterology, 2003
Colorectal cancer remains a major cause of morbidity and mortality in United States. While most newly diagnosed cases are sporadic, a small percent of colorectal cancers are due to hereditary cancer syndromes, of which hereditary nonpolyposis colorectal cancer (HNPCC) is the most common.
Deepa, Jagadeesh, Sapna, Syngal
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Hereditary Gastrointestinal Polyposis and Nonpolyposis Syndromes

New England Journal of Medicine, 1994
Colon cancer is one of the most frequent cancers in men and women in the United States.1 There is a 6 percent lifetime risk of colon cancer in the general population.1 Approximately 160,000 new cases arise every year, and despite advances in detection and therapy, 60,000 people die of colon cancer and its complications each year.2 Epidemiologic studies
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Hereditary nonpolyposis colorectal cancer: preventive management

Cancer Treatment Reviews, 2003
Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer. Inherited mutations in the mismatch repair genes associated with this syndrome have an approximate 80% lifetime risk of colorectal cancer. Since there are no premonitory signs of susceptibility to HNPCC, family history is the initial method for ...
Hwei-Ju, Annie Yu, Kevin M, Lin, David M, Ota, Henry T, Lynch   +3 more
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Extracolonic Cancer in Hereditary Nonpolyposis Colorectal Cancer

Cancer, 1990
It has been hypothesized that in some but not all families with hereditary nonpolyposis colorectal cancer (HNPCC) there is a high risk of certain cancers other than colon cancer.The authors compared the observed frequency of cancer at specific sites in more than 1300 high-risk members of 23 kindreds with HNPCC with expectations based on general ...
P, Watson, H T, Lynch
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Hereditary Nonpolyposis Colorectal Cancer

2010
Hereditary nonpolyposis colorectal cancer (HNPCC) is one of two distinct inherited colorectal cancer syndromes with known genetic defects. It is estimated to account for approximately 5% of all large bowel cancers. Originally called Lynch syndrome after Dr. Henry Lynch, it is an autosomal dominant disorder characterized by a predilection for colorectal
W. Donald Buie, Anthony R. MacLean
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