Results 181 to 190 of about 16,515 (221)

[Hereditary nonpolyposis colorectal cancer].

Ugeskrift for laeger, 1996
Hereditary non polypous colon cancer (HNPCC) is inherited in a dominant fashion, and accounts for 29-39% of all colon and rectum carcinomas occurring in people under 50 years of age. We present a case of a young male with a short history of fluctuating diarrhoea and bleeding per rectum. Family records showed a high incidence of colon and rectum cancer.
C, Eithz, H T, Vaesel, T A, Knudsen
openaire   +1 more source

Strategies for Identifying Hereditary Nonpolyposis Colon Cancer

Seminars in Oncology, 2007
Hereditary nonpolyposis colorectal cancer (HNPCC) is the term given to a predisposition syndrome caused by inherited mutations in one of at least five DNA mismatch repair (MMR) genes. Dominant mutations in these genes predispose individuals to a range of cancers in addition to the most frequent, colorectal cancer. Endometrial cancer is the most notable
D Gareth, Evans, Sheila, Walsh, James, Hill, Raymond T, McMahon   +3 more
openaire   +2 more sources

[Hereditary nonpolyposis colorectal cancers].

Praxis, 1996
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal, dominantly inherited disease leading to a marked increase in cancer susceptibility, notably colorectal cancer, affecting up to one in 400 individuals in the Western world. Four genes responsible for the majority of cases have been identified.
S, Caplin, M T, Constanda, J C, Givel
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Recent Developments in Hereditary Nonpolyposis Colorectal Cancer

Scandinavian Journal of Gastroenterology, 1996
Hereditary non-polyposis colorectal cancer (HNPCC) is characterized by early onset of colorectal carcinoma (CRC), usually located proximally to the splenic flexure and reportedly carrying a better survival as compared to sporadic-type CRC. Depending on the absence or presence of extracolonic tumours, particularly carcinomas of the endometrium, stomach ...
M E, Craanen, P, Blok, G J, Offerhaus, G N, Tytgat   +3 more
openaire   +2 more sources

Pathology of Hereditary Nonpolyposis Colorectal Cancer

Annals of the New York Academy of Sciences, 2000
Abstract: The magnitude of the pathologist's role in the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) is underestimated. The diagnostic features are not specific to HNPCC cancers, but relate to all cancers showing high levels of DNA microsatellite instability (MSI‐H).
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Gynecologic screening in hereditary nonpolyposis colorectal cancer

Gynecologic Oncology, 2003
In hereditary nonpolyposis colorectal cancer (HNPCC), women with a mismatch repair (MMR) gene mutation have a cumulative lifetime risk of 25-50% for endometrial cancer and 8-12% for ovarian cancer. Therefore, female members of HNPCC families are offered an annual gynecologic and transvaginal ultrasound (TVU) examination and serum level CA 125 analysis.
Rijcken, FEM, Mourits, MJE, Kleibeuker, JH, Hollema, H, van der Zee, AGJ   +4 more
openaire   +3 more sources

Hereditary Nonpolyposis Colon Cancer

American Journal of Nursing, 1998
R J, Cavalieri, B, Franklin
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Surgical Management of Hereditary Nonpolyposis Colorectal Cancer

Advances in Surgery, 2011
HNPCC is a diverse disease with significant colorectal and extracolonic malignancy risk. A high index of suspicion is necessary to identify patients and families who potentially have this disease. Patients suspected with Lynch syndrome should be referred for genetic counseling and testing for accurate diagnosis. Timely surveillance and intervention are
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Current Approaches in Hereditary Nonpolyposis Colorectal Cancer

Journal of the National Comprehensive Cancer Network, 2012
This article emphasizes the central role of tumor-based testing for microsatellite instability followed by performance of genetic counselor-driven germline mutation testing in hereditary nonpolyposis colorectal cancer (HNPCC). Suitably aggressive colorectal neoplasm surveillance is shown to be critical.
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Genetic testing in prostate cancer management: Considerations informing primary care

Ca-A Cancer Journal for Clinicians, 2022
Veda N Giri, Jacob E Berchuck, Mary-Ellen Taplin   +2 more
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