Results 31 to 40 of about 16,515 (221)

Molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome)

Revista de la Facultad de Medicina, 2016
Lynch syndrome is the most common cause of inherited colorectal cancer, totaling 5 to 8% of all the cases with high susceptibility to this type of cancer and extracolonic cancer.
David Serrano, Clara Eugenia Arteaga
doaj   +1 more source

A comprehensive custom panel evaluation for routine hereditary cancer testing: improving the yield of germline mutation detection

Journal of Translational Medicine, 2020
Background In the context of our Regional Program of Hereditary Cancer, individuals fulfilling the criteria are tested for germline mutations to subsequently establish the clinical management.
Carolina Velázquez, Enrique Lastra, Francisco Avila Cobos, Luis Abella, Virginia de la Cruz, Blanca Ascensión Hernando, Lara Hernández, Noemí Martínez, Mar Infante, Mercedes Durán   +9 more
doaj   +1 more source

Role of APC and DNA mismatch repair genes in the development of colorectal cancers

Molecular Cancer, 2003
Colorectal cancer is the third most common cause of cancer-related death in both men and women in the western hemisphere. According to the American Cancer Society, an estimated 105,500 new cases of colon cancer with 57,100 deaths will occur in the U.S ...
Roy Deodutta, Narayan Satya
doaj   +1 more source

Lynch syndrome: An unusal case of familial cancer unearthed

Indian Journal of Pathology and Microbiology, 2022
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer.
Subhra Dhar, Ashraf U Mannan, J Jaya Singh, Sandipan Dhar, Swetalina Pradhan   +4 more
doaj   +1 more source

Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. [PDF]

, 2008
Individuals with Lynch syndrome are predisposed to cancer due to an inherited DNA mismatch repair gene mutation. However, there is significant variability observed in disease expression likely due to the influence of other environmental, lifestyle, or ...
Amos, Christopher I, Broaddus, Russell, Chen, Jinyun, Frazier, Marsha L, Lynch, Patrick M, Osterwisch, Daniel R, Pande, Mala   +6 more
core   +1 more source

Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x. [PDF]

PLoS ONE, 2013
Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects.We
Mev Dominguez-Valentin, Christina Therkildsen, Srinivas Veerla, Mats Jönsson, Inge Bernstein, Ake Borg, Mef Nilbert   +6 more
doaj   +1 more source

Primary retroperitoneal nodal endometrioid carcinoma associated with Lynch syndrome: A case report

Frontiers in Oncology, 2023
We report a rare case of primary nodal, poorly differentiated endometrioid carcinoma associated with Lynch syndrome. A 29-year-old female patient was referred by her general gynecologist for further imaging with suspected right-sided ovarian endometrioid
Daniela Fischerova, Umberto Scovazzi, Natacha Sousa, Tatevik Hovhannisyan, Andrea Burgetova, Pavel Dundr, Kristýna Němejcová, Rosalie Bennett, Michal Vočka, Filip Frühauf, Roman Kocian, Tereza Indrielle-Kelly, David Cibula   +12 more
doaj   +1 more source

Mismatch repair genes founder mutations and cancer susceptibility in Lynch syndrome [PDF]

, 2015
..
Alonso-Espinaco, Ashley-Koch, Baglietto, Behar, Berends, Boland, Borelli, Borelli, Borras, Caluseriu, Castellsague, Cavalli-Sforza, Cederquist, Chan, Chan, Chong, Clendenning, Clendenning, Desai, Dominguez-Valentin, Fishel, Fokkema, Foulkes, Froggatt, Froggatt, Goldberg, Gomez, Grindedal, Gruber, Gruber, Guo, Hendriks, Hiljadnikova-Bajro, Hitchins, Hitchins, Hutter, Jager, Jenkins, Karami, Kimura, Kwok, Lang, Lastella, Leon, Ligtenberg, Lohmann, Lopez-Escribano, Lynch, Lynch, Lynch, Lynch, Mangold, McPeek, Medina-Arana, Menendez, Miyaki, Moisio, Morak, Morral, Mur, Nicolaides, Niell, Nystrom-Lahti, Olsson, Palomaki, Papadopoulos, Peltomaki, Pensotti, Perez-Cabornero, Pineda, Pinheiro, Pinheiro, Plaschke, Pritchard, Ramsoekh, Rannala, Rannala, Raskin, Reeve, Riel, Ripa, Salovaara, Senter, Shin, Shiri-Sverdlov, Sjursen, Slatkin, Slatkin, Stella, Stella, Sun, Tamura, Tang, Therkildsen, Thiffault, Tomsic, Tomsic, Vahteristo, Valentin, Vasen, Wagner, Wimmer   +101 more
core   +1 more source

Patient‐Reported‐Outcome‐Measures (PROMs) After Gastrointestinal Endoscopic Resections

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Data on patient‐reported outcome measures (PROMs) of patients undergoing endoscopic resections have been sparse. The aim of our study was the prospective assessment of the Gastrointestinal Quality of Life Index (GIQLI) as a baseline and post‐endoscopic resection (ER) measurement in patients with epithelial mucosal neoplasms ...
Laura Retzbach, Karl‐Hermann Fuchs, Markus Brand, Thomas J. Lux, Alexander Meining   +4 more
wiley   +1 more source

Urothelial carcinoma: Perioperative considerations from top to bottom

CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 528-551, November/December 2025.
Abstract Urothelial carcinoma is an aggressive entity that is associated with significant morbidity, but there have been major advances in both our understanding of and treatment options for patients with this disease. In this review, the authors focus on novel therapeutic and diagnostic approaches in the perioperative setting, with an emphasis on ...
Wesley Yip, Salvador Jaime‐Casas, Anjaney Kothari, Mary Sullivan, Leslie K. Ballas, Domenique Escobar, Anne K. Schuckman, Jonathan E. Rosenberg, Jonathan A. Coleman   +8 more
wiley   +1 more source