Quality of Life in Adult Individuals Living With or at Risk of a Hereditary Cancer Predisposition Syndrome: A Scoping Review of the Qualitative Literature. [PDF]
Cancer MedABSTRACT Background The in‐depth understanding of the impact of a hereditary cancer predisposition syndrome (HCPS) on the health‐related quality of life (HRQOL) of individuals with a hereditary cancer burden contributes to the improvement of counselling strategies as well as care planning and informs the development of patient‐reported outcome measures
Sztankay M +9 more
europepmc +2 more sources
A Comparison Between Denaturing Gradient Gel Electrophoresis and Denaturing High Performance Liquid Chromatography in Detecting Mutations in Genes Associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and the Identification of 9 New Mutations Previously Unidentified by DGGE [PDF]
, 2003 Denaturing high performance liquid chromatography is a relatively new method by which heteroduplex structures formed during the PCR amplification of heterozygote samples can be rapidly identified.
Meldrum Cliff J +8 more
core +2 more sources
Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. [PDF]
, 2008 Individuals with Lynch syndrome are predisposed to cancer due to an inherited DNA mismatch repair gene mutation. However, there is significant variability observed in disease expression likely due to the influence of other environmental, lifestyle, or ...
Amos, Christopher I +6 more
core +1 more source
Role of
Molecular Cancer, 2003 Colorectal cancer is the third most common cause of cancer-related death in both men and women in the western hemisphere. According to the American Cancer Society, an estimated 105,500 new cases of colon cancer with 57,100 deaths will occur in the U.S ...
Roy Deodutta, Narayan Satya
doaj +1 more source
Lynch syndrome: An unusal case of familial cancer unearthed
Indian Journal of Pathology and Microbiology, 2022 Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer.
Subhra Dhar +4 more
doaj +1 more source
Prevalence of Lynch Syndrome among Patients with Newly Diagnosed Endometrial Cancers [PDF]
, 2013 Background: Lynch syndrome (LS) is a hereditary condition that increases the risk for endometrial and other cancers. The identification of endometrial cancer (EC) patients with LS has the potential to influence life-saving interventions.
Alenda, Cristina +17 more
core +4 more sources
Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x. [PDF]
PLoS ONE, 2013 Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects.We
Mev Dominguez-Valentin +6 more
doaj +1 more source
Primary retroperitoneal nodal endometrioid carcinoma associated with Lynch syndrome: A case report
Frontiers in Oncology, 2023 We report a rare case of primary nodal, poorly differentiated endometrioid carcinoma associated with Lynch syndrome. A 29-year-old female patient was referred by her general gynecologist for further imaging with suspected right-sided ovarian endometrioid
Daniela Fischerova +12 more
doaj +1 more source
Mismatch repair genes founder mutations and cancer susceptibility in Lynch syndrome [PDF]
, 2015 ..
Alonso-Espinaco +101 more
core +1 more source
iNew Medicine, EarlyView.ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid +4 more
wiley +1 more source