Results 61 to 70 of about 16,165 (220)

Algunos aspectos genéticos, moleculares y clínicos del cáncer colorrectal hereditario no polipoideo Some genetic, molecular and clinical aspects of nonpolyposis hereditary colorectal cancer

Revista Cubana de Investigaciones Biomédicas, 2004
Se hizo una revisión con el objetivo de profundizar en el conocimiento del cáncer colorrectal hereditario no polipoideo; resaltando su evolución histórica, así como sus características genéticas, moleculares y clínicas que condicionan el manejo clínico ...
Silvia Gra Menéndez, Diana Cruz-Bustillo Clarens   +1 more
doaj  

HEREDITARY NON-POLYPOSIS COLORECTAL CANCER (LYNCH SYNDROME) PADA WANITA UMUR 16 TAHUN

Majalah Kedokteran Andalas, 2011
AbstrakKanker kolorektal menduduki peringkat ketiga jenis kanker yang paling sering terjadi di dunia. Sekitar 3% kasus kanker kolorektal merupakan jenis hereditary non polyposis colorectal cancer (HNPCC)/Lynch syndrome, yang sering muncul pada usia muda.
Asril Zahari, Sudiyatmo Sudiyatmo
doaj   +1 more source

Associations of the Colon Tissue Microbiome and Circulating Bile Acids With Colorectal Adenoma Among Average‐Risk Women

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Objective The gut microbiome and bile acids (BAs) likely influence colorectal cancer (CRC) development and disparities. We conducted a nested case–control study of the associations of the colon tissue microbiome and circulating BAs with colorectal adenoma prevalence in the previously conducted multi‐center Colorectal Neoplasia Screening with ...
Doratha A. Byrd, Maria F. Gomez, Stephanie R. Hogue, Jessica R. Burns, Nate Smith, Joshua Sampson, Erikka Loftfield, Patricia G. Wolf, Yunhu Wan, Andrew Warner, Belynda Hicks, Casey Dagnall, Kristine Jones, Youngchul Kim, Jin Xu, Jianxin Shi, Rashmi Sinha, Emily Vogtmann   +17 more
wiley   +1 more source

Malignant phyllodes tumor in Lynch syndrome: a case report

Journal of Medical Case Reports, 2019
Background Lynch syndrome, or hereditary nonpolyposis colorectal cancer, is an autosomal dominant genetic syndrome that predisposes individuals to multiple cancer types.
Shayma Kazmi, Steven Wagner, Rebecca Heintzelman, Melanie Corbman   +3 more
doaj   +1 more source

Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Diagnostics [PDF]

JNCI Journal of the National Cancer Institute, 2007
Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance.
Kristina, Lagerstedt Robinson, Tao, Liu, Jana, Vandrovcova, Britta, Halvarsson, Mark, Clendenning, Thierry, Frebourg, Nickolas, Papadopoulos, Kenneth W, Kinzler, Bert, Vogelstein, Päivi, Peltomäki, Richard D, Kolodner, Mef, Nilbert, Annika, Lindblom   +12 more
openaire   +2 more sources

DNA Mismatch Repair in Eukaryotes and Bacteria

Journal of Nucleic Acids, 2010
DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human ...
Kenji Fukui
doaj   +1 more source

The Quality of Life of Patients with Hereditary Nonpolyposis Colorectal Cancer Undergoing Preoperative Chemoradiation

Applied Sciences, 2020
Of all the neoplastic sites, colorectal cancer (CRC) is one of the most common cancers in the family. Studies estimate that approximately 30% of all the CRC cases are a hereditary form of the disease with a potentially high impact on the quality of life (
Valeriu Aurelian Chirica, Mioara Matei, Roxana Postolica, Liliana Chelaru, Irina Mihaela Esanu, Lidia Sanduleac, Vlad Porumb, Mihaela Boanca, Elena Adorata Coman, Doina Azoicai   +9 more
doaj   +1 more source

Germline Cancer Susceptibility Variants in Patients With Uveal Melanoma

Pigment Cell &Melanoma Research, Volume 38, Issue 5, September 2025.
Germline exome sequencing of 106 Finnish patients with UM, considered at higher risk for genetic cancer predisposition, identified pathogenic or likely pathogenic variants associated with varying risk of malignancies in 16 patients (15%). Six patients (6%) carried multiple variants and had a median diagnosis age of 51, compared to 60 in the full cohort
Pauliina E. Repo, Eveliina Jakkula, Juho Hiltunen, Heidi Putkuri, Aleksandra Staskiewicz‐Tuikkanen, Reetta‐Stiina Järvinen, Martin Täll, Virpi Raivio, Rana'a T. Al‐Jamal, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Frequency of the Common MYH Mutations (G382D and Y165C) in MMR Mutation Positive and Negative HNPCC Patients [PDF]

, 2005
Recently mutations in the MYH gene have been associated with a milder form of adenomatous polyposis which is characterized by a variable level of colonic polyps ranging from a few to several hundred.
Katie A Ashton, Cliff J Meldrum, Mary L McPhillips, Carla F Kairupan, Rodney J Scott   +4 more
core   +1 more source

Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease)

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
(A) Post hoc pairwise comparisons between the four studied groups regarding the log2 of serum fold change of CircFUNDC1. There were significant differences between CRC, UC, or CD and controls. p values (Controls vs. UC = < 0.001, Controls vs. CD = < 0.001, Controls vs. CRC = < 0.001, UC vs. CD = 1.000, UC vs. CRC = 0.194, CD vs. CRC = 0.255).
Marwa A. Ali, Olfat G. Shaker, Eman M. Ezzat, Abeer A. Khalefa, Naglaa A. Ahmed, Raghda Yahia Abu El‐Ela, Amal A. Ibrahim Amin, Fatma Abdel Hamid Mohamed, Marwa Mamdouh Ahmed Abdelhafeez, Mohamed Saad Zaghloul Ahmed, Marwa N. AbdelHafez, Abdulrhman Khaled Al Abdulqader, Reham Fares   +12 more
wiley   +1 more source