Results 61 to 70 of about 16,515 (221)

DNA Mismatch Repair in Eukaryotes and Bacteria

Journal of Nucleic Acids, 2010
DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human ...
Kenji Fukui
doaj   +1 more source

Malignant phyllodes tumor in Lynch syndrome: a case report

Journal of Medical Case Reports, 2019
Background Lynch syndrome, or hereditary nonpolyposis colorectal cancer, is an autosomal dominant genetic syndrome that predisposes individuals to multiple cancer types.
Shayma Kazmi, Steven Wagner, Rebecca Heintzelman, Melanie Corbman   +3 more
doaj   +1 more source

Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Diagnostics [PDF]

JNCI Journal of the National Cancer Institute, 2007
Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance.
Kristina, Lagerstedt Robinson, Tao, Liu, Jana, Vandrovcova, Britta, Halvarsson, Mark, Clendenning, Thierry, Frebourg, Nickolas, Papadopoulos, Kenneth W, Kinzler, Bert, Vogelstein, Päivi, Peltomäki, Richard D, Kolodner, Mef, Nilbert, Annika, Lindblom   +12 more
openaire   +2 more sources

Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease)

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
(A) Post hoc pairwise comparisons between the four studied groups regarding the log2 of serum fold change of CircFUNDC1. There were significant differences between CRC, UC, or CD and controls. p values (Controls vs. UC = < 0.001, Controls vs. CD = < 0.001, Controls vs. CRC = < 0.001, UC vs. CD = 1.000, UC vs. CRC = 0.194, CD vs. CRC = 0.255).
Marwa A. Ali, Olfat G. Shaker, Eman M. Ezzat, Abeer A. Khalefa, Naglaa A. Ahmed, Raghda Yahia Abu El‐Ela, Amal A. Ibrahim Amin, Fatma Abdel Hamid Mohamed, Marwa Mamdouh Ahmed Abdelhafeez, Mohamed Saad Zaghloul Ahmed, Marwa N. AbdelHafez, Abdulrhman Khaled Al Abdulqader, Reham Fares   +12 more
wiley   +1 more source

Clinical and genetic aspects of differential diagnostics of hereditary non-polyposis colorectal cancer

Успехи молекулярной онкологии, 2019
Lynch syndrome was synonymous with hereditary non-polyposis colorectal cancer for a long time, however, mapping of the DNA mismatch repair (MMR) genes has led to distinguish Lynch syndrome as an independent syndromic unit from a number of Lynch-like ...
A. V. Semyanikhina, A. O. Rasulov, L. N. Lyubchenko   +2 more
doaj   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

The Quality of Life of Patients with Hereditary Nonpolyposis Colorectal Cancer Undergoing Preoperative Chemoradiation

Applied Sciences, 2020
Of all the neoplastic sites, colorectal cancer (CRC) is one of the most common cancers in the family. Studies estimate that approximately 30% of all the CRC cases are a hereditary form of the disease with a potentially high impact on the quality of life (
Valeriu Aurelian Chirica, Mioara Matei, Roxana Postolica, Liliana Chelaru, Irina Mihaela Esanu, Lidia Sanduleac, Vlad Porumb, Mihaela Boanca, Elena Adorata Coman, Doina Azoicai   +9 more
doaj   +1 more source

Microsatellite Instability in the Tumor Microenvironment: The Role of Inflammation and the Microbiome

Cancer Medicine, Volume 14, Issue 8, April 2025.
The microbiome, an environmental factor, can contribute to DNA damage and affect mutation accumulation. Infections with genotoxin‐producing pathobionts can induce inflammation and oxidative stress through reactive nitrogen and oxygen species, which may influence MSI.
Elizabeth Vargas‐Castellanos, Andrés Rincón‐Riveros   +1 more
wiley   +1 more source

Identification of Diagnostic Biomarkers for Colorectal Polyps Based on Noninvasive Urinary Metabolite Screening and Construction of a Nomogram

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Purpose/Backgrounds Colorectal polyps (CRPs) are precursors to colorectal cancer (CRC), and early detection is crucial for prevention. Traditional diagnostic methods are invasive, prompting a need for noninvasive biomarkers. This study aimed to identify urinary metabolite biomarkers for diagnosing CRPs and construct a diagnostic nomogram based
Yang Xie, Yiyi Jin, Zide Liu, Jun Li, Qing Tao, Yonghui Wu, Youxiang Chen, Chunyan Zeng   +7 more
wiley   +1 more source

Recognition and management of hereditary colorectal cancer syndromes [PDF]

, 2009
Over 1,900 colorectal tumors will arise in association with a hereditary colorectal cancer syndrome in Spain in 2009. The genetic defects responsible for the most common syndromes have been discovered in recent years. Genetic testing
Herraiz-Bayod, M.J. (Maite J.), Muñoz-Navas, M. (Miguel)   +1 more
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