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Hereditary Nonpolyposis Colon Cancer (Lynch Syndrome): An Emerging Public Health Concern [PDF]

Health Science Reports
Background Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes that confer increased lifetime risks for colorectal, endometrial,
Md Mohiuddin
doaj   +3 more sources

Extensive colectomy in colorectal cancer and hereditary nonpolyposis colorectal cancer – long-term results [PDF]

Journal of Coloproctology, 2019
Background: Colorectal cancer survival is better in hereditary nonpolyposis colorectal cancer patients than in sporadic colorectal cancer patients and even for hereditary nonpolyposis colorectal cancer with colorectal cancer is not consensual that ...
Marisa D. Santos, Cláudio Silva, João Oliveira, Pedro Brandão, Mónica Sampaio, Ana Cristina Silva, Anabela Rocha, Eduarda Matos, Ricardo Marcos-Pinto   +8 more
doaj   +4 more sources

Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Diagnostics [PDF]

JNCI Journal of the National Cancer Institute, 2007
Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance.
Kristina Lagerstedt‐Robinson, Thalia D. Liu, Jana Vandrovcová, B. Halvarsson, Mark Clendenning, Thierry Frébourg, Nikolaos G. Papadopoulos, K. W. Kinzler, Bert Vogelstein, Païvi Peltomäki, Richard D. Kolodner, Mef Nilbert, Annika Lindblom   +12 more
openalex   +3 more sources

Hereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2021
Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various ...
Mohammad Hassan Jokar, Sima Sedighi, Maliheh Moradzadeh   +2 more
doaj   +2 more sources

Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome. [PDF]

Dtsch Arztebl Int, 2013
Hereditary nonpolyposis colorectal cancer HNPCC, Lynch syndrome) is a genetic disease of autosomal dominant inheritance. It is caused by a mutation in one of four genes of the DNA mismatch repair system and confers a markedly increased risk for various types of cancer, particularly of the colon and the endometrium.
Steinke V, Engel C, Büttner R, Schackert HK, Schmiegel WH, Propping P.   +5 more
europepmc   +4 more sources

Numbers of mutations to different types of colorectal cancer [PDF]

BMC Cancer, 2005
Background The numbers of oncogenic mutations required for transformation are uncertain but may be inferred from how cancer frequencies increase with aging. Cancers requiring more mutations will tend to appear later in life.
Tavaré Simon, Aaltonen Lauri A, Järvinen Heikki J, Mecklin Jukka-Pekka, Calabrese Peter, Shibata Darryl   +5 more
doaj   +3 more sources

Prediction of hereditary nonpolyposis colorectal cancer using mRNA MSH2 quantitative and the correlation with nonmodifiable factor. [PDF]

World J Gastrointest Pathophysiol, 2021
Tedjasaputra TR, Hatta M, Massi MN, Natzir R, Bukhari A, Masadah R, Parewangi ML, Prihantono P, Nariswati R, Tedjasaputra V.   +9 more
europepmc   +2 more sources

Algunos aspectos genéticos, moleculares y clínicos del cáncer colorrectal hereditario no polipoideo Some genetic, molecular and clinical aspects of nonpolyposis hereditary colorectal cancer

Revista Cubana de Investigaciones Biomédicas, 2004
Se hizo una revisión con el objetivo de profundizar en el conocimiento del cáncer colorrectal hereditario no polipoideo; resaltando su evolución histórica, así como sus características genéticas, moleculares y clínicas que condicionan el manejo clínico ...
Silvia Gra Menéndez, Diana Cruz-Bustillo Clarens   +1 more
doaj   +1 more source

Hereditary Nonpolyposis Colorectal Cancer [PDF]

, 2020
Lars Bo Svendsen
openalex   +2 more sources

Characteristics of hereditary nonpolyposis colorectal cancer patients with double primary cancers in endometrium and colorectum. [PDF]

Obstet Gynecol Sci, 2015
Shin SH, Yu EJ, Lee YK, Song YS, Seong MW, Park SS.   +5 more
europepmc   +3 more sources