Results 71 to 80 of about 16,555 (261)

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Microsatellite Instability in the Tumor Microenvironment: The Role of Inflammation and the Microbiome

Cancer Medicine, Volume 14, Issue 8, April 2025.
The microbiome, an environmental factor, can contribute to DNA damage and affect mutation accumulation. Infections with genotoxin‐producing pathobionts can induce inflammation and oxidative stress through reactive nitrogen and oxygen species, which may influence MSI.
Elizabeth Vargas‐Castellanos, Andrés Rincón‐Riveros   +1 more
wiley   +1 more source

A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America [PDF]

, 2017
Background: Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spectrum of patients with suspected ...
A Giraldo, A Gomez, A Mendoza Sanchez, A Recalde, A Stella, A Umar, A Wagner, AD Clarizia, Adriana Della Valle, AL Moisio, Alexandra Martins, AM Wielandt, André Escremim de Paula, AR Cajal, BA Thompson, Benedito Mauro Rossi, BM Rossi, BM Rossi, C Castro-Mujica Mdel, C Castro-Mujica Mdel, C Houdayer, C Nique Carbajal, C Ortiz, C Sarroca, CA Vaccaro, CA Vaccaro, CA Vaccaro, Carlos Alberto Vaccaro, Carlos Sarroca, CG Rasuck, Claudia Barletta-Carrillo, CM Egoavil, Constantino Dominguez-Barrera, DD Buchanan, DE Germini, DV Viana, E Borras, Edenir Inêz Palmero, Eivind Hovig, Enrique Spirandelli, Erika Maria Monteiro-Santos, Evaluation of Genomic Applications in P, Prevention Working G, FC Silva da, Florencia Neffa, Florencia Spirandelli, Francisco López-Kostner, G Casey, G Chong, G Ponti, G Yeo, GH Garcia, H Hampel, H Kobayashi, H Song, Henrique de Campos Reis Galvão, HF Vasen, HF Vasen, Hélène Tubeuf, I Borelli, I Thiffault, IN Freitas de, J Norum, J Risco, JP Plazzer, JT Dunnen den, Julio Sanchez de Monte, K Alvarez, Karin Alvarez, L Perez-Cabornero, L. Lena Morillas, Luis Gustavo Capochin Romagnolo, M Aarnio, M Clendenning, M Cruz-Correa, M Dominguez-Valentin, M Nystrom-Lahti, M Pinheiro, M Pinheiro, M Rodriguez-Soler, M Roque, M Tanyi, MA Ramirez-Ramirez, MA RodriguezBigas, Maria del Carmen Castro-Mujica, MD Valentin, MD Valentin, Melva Gutiérrez Angulo, Mev Dominguez-Valentin, NJ Froggatt, Norma Teresa Rossi, O Soukarieh, P Ashton-Prolla, P Koehler-Santos, P Lastella, P Vahteristo, Pablo German Kalfayan, Patricia Ashton-Prolla, Patrik Wernhoff, Pål Møller, Richard Quispe, RP Kuiper, Rui Manuel Reis, S Gupta, Sabrina Daniela da Silva, Sergio Chialina, SMO Leite, Susana Revollo, Tamara Alejandra Piñero, V Alonso-Espinaco, W Sjursen, WE Jesus-Monge De, Ximena Taborga, Y Montenegro, Yenni Rodriguez   +113 more
core   +4 more sources

Identification of Diagnostic Biomarkers for Colorectal Polyps Based on Noninvasive Urinary Metabolite Screening and Construction of a Nomogram

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Purpose/Backgrounds Colorectal polyps (CRPs) are precursors to colorectal cancer (CRC), and early detection is crucial for prevention. Traditional diagnostic methods are invasive, prompting a need for noninvasive biomarkers. This study aimed to identify urinary metabolite biomarkers for diagnosing CRPs and construct a diagnostic nomogram based
Yang Xie, Yiyi Jin, Zide Liu, Jun Li, Qing Tao, Yonghui Wu, Youxiang Chen, Chunyan Zeng   +7 more
wiley   +1 more source

Prevalence of Constitutional Pathogenic Variant in a Cohort of 348 Patients With Multiple Primary Cancer Addressed in Oncogenetic Consultation

Molecular Genetics &Genomic Medicine, Volume 13, Issue 3, March 2025.
Patients recruited from the oncogenetic department with multiple cancers (348) were more likely to carry pathogenic mutations than those with a single cancer (1422) (27.3% vs. 13.39% p < 0.001). However, if the multiple primary cancers cannot be linked to the same hereditary predisposition syndrome, the prevalence of pathogenic variants is not ...
Mathis Lepage, Nancy Uhrhammer, Ioana Molnar, Maud Privat, Flora Ponelle‐Chachuat, Mathilde Gay‐Bellile, Yannick Bidet, Mathias Cavaillé   +7 more
wiley   +1 more source

SPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMA

Сибирский онкологический журнал, 2016
Colorectal cancer is one of the most common malignancies and the leading cause of cancer-related death. There are 4 basic colon carcinogenic steps: malignant transformation of adenoma into carcinoma; HNPCC (hereditary nonpolyposis colon cancer); cancer ...
G. A. Raskin, S. V. Petrov, R. V. Orlova
doaj  

Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome

Dermatology Research and Practice, 2010
Cutaneous neoplasms including sebaceous tumors, keratoacanthomas, and basal cell carcinomas with sebaceous differentiation can be markers of internal malignancy associated with the Muir-Torre Syndrome (MTS).
Michael C. Lynch, Bryan E. Anderson
doaj   +1 more source

Recognition and management of hereditary colorectal cancer syndromes [PDF]

, 2009
Over 1,900 colorectal tumors will arise in association with a hereditary colorectal cancer syndrome in Spain in 2009. The genetic defects responsible for the most common syndromes have been discovered in recent years. Genetic testing
Herraiz-Bayod, M.J. (Maite J.), Muñoz-Navas, M. (Miguel)   +1 more
core  

Comparative sequencing study of mismatch repair and homology‐directed repair genes in endometrial cancer and breast cancer patients from Kazakhstan

International Journal of Cancer, Volume 156, Issue 4, Page 764-775, 15 February 2025.
What's new? In high‐risk families, endometrial cancer appears to be mainly triggered by pathogenic variants in mismatch repair genes, and breast cancer by pathogenic variants in homology‐directed repair genes. However, the two pathways are not mutually exclusive.
Ying Zheng, Natalia Vdovichenko, Peter Schürmann, Dhanya Ramachandran, Robert Geffers, Lisa‐Marie Speith, Natalia Bogdanova, Julia Enßen, Natalia Dubrowinskaja, Tatyana Yugay, Zura Berkutovna Yessimsiitova, Nurzhan Turmanov, Peter Hillemanns, Thilo Dörk   +13 more
wiley   +1 more source

Hereditary Colorectal Cancer (CRC) Program in Latvia

Hereditary Cancer in Clinical Practice, 2003
Introduction The aim of the study is to evaluate the incidence and phenotype - genotype characteristics of hereditary colorectal cancer syndromes in Latvia in order to develop the basis of clinical management for patients and their relatives affected by ...
Irmejs Arvids, Gardovskis Andris, Borosenko Viktors, Bitina Marianna, Aigare Diana, Kurzawski Grzegorz, Suchy Janina, Górski Bohdan, Gardovskis Janis   +8 more
doaj   +1 more source