Results 151 to 160 of about 33,807 (258)

Reduced sensitivity of HERG S620T to quinidine

, 2000
Minako Kimura, Masahiro Takahashi, Masao Endoh, Kuniaki Ishii   +3 more
openalex   +1 more source

An amino acid residue whose change by mutation affects drug binding to the HERG channel [PDF]

, 2001
Kuniaki Ishii, Kazumi Kondo, Masahiro Takahashi, Minako Kimura, Masao Endoh   +4 more
openalex   +1 more source

Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy. [PDF]

Sci Adv
Liu X, Dhumal D, Santofimia-Castaño P, Liu J, Casanova M, Garcia-Muñoz AC, Perles-Barbacaru TA, Elkihel A, Zhang W, Roussel T, Galanakou C, Wu J, Zerva E, Dusetti N, Xia Y, Liang XJ, Viola A, Iovanna JL, Peng L.   +18 more
europepmc   +1 more source

Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine [PDF]

, 2002
Ashok A Paul, Harry J. Witchel, Jules C. Hancox   +2 more
openalex   +1 more source

FDA's insights: implementing new strategies for evaluating drug-induced QTc prolongation. [PDF]

J Pharmacokinet Pharmacodyn
Ji Y, Johannesen L, Garnett C.
europepmc   +1 more source

IRAK1/4/pan-FLT3 Kinase Inhibitors with Reduced hERG Block as Treatments for Acute Myeloid Leukemia. [PDF]

ACS Med Chem Lett
Hoyt SB, Finocchio CJ, Croll E, Tawa GJ, Zhang M, Wang J, Li H, Ma L, Li K, Zhang X, Xu X, Shah P, Fang Y, Bolanos LC, Gracia-Maldonado G, Kolt A, Robinson C, Free J, Edmondson EF, Difilippantonio S, Jones LM, Culver-Cochran AE, Rosenbaum JS, Starczynowski DT, Thomas CJ.   +24 more
europepmc   +1 more source

Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels [PDF]

, 2002
Jun Chen, Guiscard Seebohm, Michael C. Sanguinetti   +2 more
openalex   +1 more source

Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations. [PDF]

J Biomed Sci
Kumawat A, Tavazzani E, Lentini G, Trancuccio A, Kukavica D, Oldani A, Denegri M, Priori SG, Camilloni C.   +8 more
europepmc   +1 more source

[3H]Dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen

, 2001
Keith Finlayson, L Turnbull, Craig T. January, John Sharkey, John S. Kelly   +4 more
openalex   +1 more source

Recent advances in AI-based toxicity prediction for drug discovery. [PDF]

Front Chem
Lee H, Kim J, Kim JW, Lee Y.
europepmc   +1 more source