Results 51 to 60 of about 31,297 (199)

Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts

Journal of Pharmacological Sciences, 2013
In short QT syndrome, inherited gain-of-function mutations in the human ether a-go-go-related gene (hERG) K+ channel have been associated with development of fatal arrhythmias. This implies that drugs that activate hERG as a side effect may likewise pose
Mahoko Asayama, Junko Kurokawa, Kiyoshi Shirakawa, Hisashi Okuyama, Toshiki Kagawa, Jun-ichi Okada, Seiryo Sugiura, Toshiaki Hisada, Tetsushi Furukawa   +8 more
doaj   +1 more source

Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue

Pharmaceuticals, 2023
hERG (human Ether-à-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (IKr) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form of ...
Matthew V. Helliwell, Yihong Zhang, Aziza El Harchi, Christopher E. Dempsey, Jules C. Hancox   +4 more
doaj   +1 more source

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations. [PDF]

, 2019
Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome.
Chen, I-Shan, Furutani, Kazuharu, Handa, Kenichiro, Kurachi, Yoshihisa, Sack, Jon T, Tsumoto, Kunichika, Yamakawa, Yuko   +6 more
core   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

Environmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min, Seunghee Oh, Min Seong Jang, Kang‐Hyun Han   +3 more
wiley   +1 more source

Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley   +2 more sources

Global analysis reveals families of chemical motifs enriched for HERG inhibitors.

PLoS ONE, 2015
Promiscuous inhibition of the human ether-à-go-go-related gene (hERG) potassium channel by drugs poses a major risk for life threatening arrhythmia and costly drug withdrawals.
Fang Du, Joseph J Babcock, Haibo Yu, Beiyan Zou, Min Li   +4 more
doaj   +1 more source

Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. [PDF]

PLoS ONE, 2015
Human Ether á go-go Related Gene potassium channels form the rapid component of the delayed-rectifier (IKr) current in the heart. The N-terminal 'eag' domain, which is composed of a Per-Arnt-Sim (PAS) domain and a short PAS-cap region, is a critical ...
Qiang-Ni Liu, Matthew C Trudeau
doaj   +1 more source

Analysis and prediction of injury severity in single micromobility crashes with Random Forest

Heliyon, 2023
Urban micromobility represents a significant shift towards sustainable cities, underscoring the paramount importance of its safety. With the surge in micromobility adoption, collisions involving micromobility devices, such as bicycles and e-scooters ...
Almudena Sanjurjo-de-No, Ana María Pérez-Zuriaga, Alfredo García   +2 more
doaj   +1 more source

The Large Area Radio Galaxy Evolution Spectroscopic Survey (LARGESS): survey design, data catalogue and GAMA/WiggleZ spectroscopy [PDF]

, 2016
© 2016 The Authors. We present the Large Area Radio Galaxy Evolution Spectroscopic Survey (LARGESS), a spectroscopic catalogue of radio sources designed to include the full range of radio AGN populations out to redshift z ~ 0.8. The catalogue covers ~800
Ching, John H.Y., Couch, Warrick J., Croom, Scott M., Hopkins, A. M., Johnston, Helen M., Jurek, Russell J., Pimbblet, K. A., Pracy, Michael B., Sadler, Elaine M.   +8 more
core   +2 more sources

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, EarlyView.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source