Results 71 to 80 of about 36,434 (294)

Analysis of a Driving Simulator’s Steering System for the Evaluation of Autonomous Vehicle Driving

Sensors
The integration of autonomous vehicles (AVs) into road transport requires robust experimental tools to analyze the human–machine interaction, particularly under conditions of system disengagement.
Juan F. Dols, Samuel Boix, Jaime Molina, Sara Moll, Francisco J. Camacho, Griselda López   +5 more
doaj   +1 more source

Chaperone Rer1 involves in transport of hERG potassium channel protein in cell line HEK293T [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the role of Rer1 in hERG potassium channel protein transport,and to study the medicine Baf A1 that may restore abnormal hERG transport.
CHEN Bang-sheng, YU Xiao-ling, MAO Fei-yan, LIAN Jiang-fang, YU Xu-yun
doaj  

Stimulation of HERG channel activity by β-catenin. [PDF]

PLoS ONE, 2012
The multifunctional protein ß-catenin governs as transcription factor the expression of a wide variety of genes relevant for cell proliferation and cell survival.
Carlos Munoz, Ambrish Saxena, Tatsiana Pakladok, Evgenii Bogatikov, Jan Wilmes, Guiscard Seebohm, Michael Föller, Florian Lang   +7 more
doaj   +1 more source

The Strength of hERG Inhibition by Erythromycin at Different Temperatures Might Be Due to Its Interacting Features with the Channels

Molecules, 2023
Erythromycin is one of the few compounds that remarkably increase ether-a-go-go-related gene (hERG) inhibition from room temperature (RT) to physiological temperature (PT).
Dongrong Cheng, Xiaofeng Wei, Yanting Zhang, Qian Zhang, Jianwei Xu, Jiaxin Yang, Junjie Yu, Antony Stalin, Huan Liu, Jintao Wang, Dian Zhong, Lanying Pan, Wei Zhao, Yuan Chen   +13 more
doaj   +1 more source

Enhancing hERG Risk Assessment with Interpretable Classificatory and Regression Models

Chemical Research in Toxicology
The human Ether-à-go-go-Related Gene (hERG) is a transmembrane protein that regulates cardiac action potential, and its inhibition can induce a potentially deadly cardiac syndrome.
Igor H Sanches, R. Braga, Vinicius M. Alves, C. Andrade   +3 more
semanticscholar   +1 more source

Computational determination of hERG-related cardiotoxicity of drug candidates

BMC Bioinformatics, 2019
Drug candidates often cause an unwanted blockage of the potassium ion channel of the human ether-a-go-go-related gene (hERG). The blockage leads to long QT syndrome (LQTS), which is a severe life-threatening cardiac side effect.
Hyang-Mi Lee, Myeong-Sang Yu, Sayada Reemsha Kazmi, Seong Yun Oh, Ki-Hyeong Rhee, M. Bae, B. Lee, Dae-Seop Shin, K. Oh, Hyithaek Ceong, Donghyun Lee, D. Na   +11 more
semanticscholar   +1 more source

Modulation of hERG 1a Trafficking by hERG 1b Subunits in Heart [PDF]

Biophysical Journal, 2016
In human heart the rapid component of the delayed rectifier potassium current (IKr), is an important contributor to repolarization. IKr exists as heterotetrameric channel complexes composed of hERG 1a/1b subunits. hERG 1b is defined by a shorter and unique N-terminus that lacks the Per-Arnt-Sim or ether-a-go-go, domain with implications for its role in
Aromolaran, Kelly A., Chang, Donald D., Zukin, R. Suzanne, Colecraft, Henry M., Chahine, Mohamed, Boutjdir, Mohamed, Aromolaran, Ademuyiwa   +6 more
openaire   +1 more source

The Study on the hERG Blocker Prediction Using Chemical Fingerprint Analysis

Molecules, 2020
Human ether-a-go-go-related gene (hERG) potassium channel blockage by small molecules may cause severe cardiac side effects. Thus, it is crucial to screen compounds for activity on the hERG channels early in the drug discovery process.
Kwang-Eun Choi, A. Balupuri, N. Kang
semanticscholar   +1 more source

In vitro chronic effects on hERG channel caused by the marine biotoxin Yessotoxin.

Frontiers in Marine Science, 2014
INTRODUCTION Marine algal blooms caused by the overgrowth of marine phytoplankton have increased in frequency and severity in the last years; supposing a worldwide public health problem.
Sara Fernández Ferreiro
doaj   +1 more source

Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block

PLoS ONE, 2020
Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QTC prolongation that crosses the 10 msec threshold of regulatory concern was observed at a supratherapeutic dose in two thorough QT studies for the transdermal
Phu N. Tran, Jiansong Sheng, Aaron L Randolph, Claudia P. Alvarez Baron, Nicolas Thiebaud, Ming Ren, Min Wu, L. Johannesen, D. Volpe, Dakshesh Patel, K. Blinova, D. Strauss, Wendy W Wu   +12 more
semanticscholar   +1 more source