Results 31 to 40 of about 16,403 (211)

AI-enabled engineering of hesperidin/ursodeoxycholic acid nanomedicine for synergistic treatment of drug-induced liver injury. [PDF]

Smart Mol
An AI‐driven framework integrating disease‐network analysis, direction‐aware molecular screening, and carrier‐free co‐assembly engineering enables nanomedicine design. The dual‐constraint deep learning model predicts API–target affinity and regulatory direction to prioritize complementary APIs.
Xiao K, Fan M, Zheng H, Gu B, Wang S, Wu Z, Zhang S, Zhao X, Zhang W, Ning Q, A S, Yang C, Sun H, Mo R, Shao D.   +14 more
europepmc   +2 more sources

The pharmacological potential of hesperidin [PDF]

, 2019
The modern scientific society has presently recognized flavonoids to be a unique class of therapeutic molecules due to their varied therapeutic properties.
Saluja, Ajay, Ganeshpurkar, Aditya
core   +1 more source

Hesperidin depolarizes the pacemaker potentials through 5-HT4 receptor in murine small intestinal interstitial cells of Cajal

Animal Cells and Systems, 2020
Hesperidin, a citrus flavonoid, can exert numerous beneficial effects on human health. Interstitial cells of Cajal (ICC) are pacemaker cells in the gastrointestinal (GI) tract.
Minwoo Hwang, Jeong Nam Kim, Byung Joo Kim   +2 more
doaj   +1 more source

A High-Yield Process for Production of Biosugars and Hesperidin from Mandarin Peel Wastes

Molecules, 2020
In this research, novel biorefinery processes for obtaining value-added chemicals such as biosugar and hesperidin from mandarin peel waste (MPW) are described.
Eun Jin Cho, Yoon Gyo Lee, Jihye Chang, Hyeun-Jong Bae   +3 more
doaj   +1 more source

The Antidepressant-Like Effects of Hesperidin in Streptozotocin‐Induced Diabetic Rats by Activating Nrf2/ARE/Glyoxalase 1 Pathway

Frontiers in Pharmacology, 2020
The co-occurrence of diabetes and depression is a challenging and underrecognized clinical problem. Alpha-carbonyl aldehydes and their detoxifying enzyme glyoxalase 1 (Glo-1) play vital roles in the pathogenesis of diabetic complications, including ...
Xia Zhu, Haiyan Liu, Yuan Liu, Yajing Chen, Yaowu Liu, Xiaoxing Yin   +5 more
doaj   +1 more source

Insight into the Inhibitory Mechanisms of Hesperidin on α-Glucosidase through Kinetics, Fluorescence Quenching, and Molecular Docking Studies

Foods, 2023
The α-glucosidase inhibitor is of interest to researchers due to its association with type-II diabetes treatment by suppressing postprandial hyperglycemia. Hesperidin is a major flavonoid in orange fruit with diverse biological properties.
Kumaravel Kaliaperumal, Linyan Zhang, Liangliang Gao, Qin Xiong, Yan Liang, Yueming Jiang, Jun Zhang   +6 more
doaj   +1 more source

Hesperidin prevents lipopolysaccharide-induced endotoxicity in rats. [PDF]

, 2016
CONTEXT Lipopolysaccharide (LPS) is a major trigger of septic shock resulting in multiple organ damage through excessive stimulation of the host's immune cells resulting in the release of cytokines.
Adelani, Isaacson Bababode, Bankole, Goodness Esther, Rotimi, Solomon Oladapo, Rotimi, Oluwakemi Anuoluwapo   +3 more
core   +3 more sources

The flavonoid hesperidin exerts anti-photoaging effect by downregulating matrix metalloproteinase (MMP)-9 expression via mitogen activated protein kinase (MAPK)-dependent signaling pathways

BMC Complementary and Alternative Medicine, 2018
Background Hesperidin is a flavonoid with antioxidant, anti-inflammatory, and immune modulatory activities. Photoaging is a consequence of chronic exposure to the sun and ultraviolet (UV) radiation.
Hee Jeong Lee, A-Rang Im, Su-Man Kim, Hyung-Sik Kang, Jae Dong Lee, Sungwook Chae   +5 more
doaj   +1 more source

Recovery of pure Hesperidin from Iraqi Sweet Oranges Peel and study the effect in some bacteria

مجلة بغداد للعلوم, 2014
Citrus fruit contain variety of flavonoids such as Hesperidin (the principal flavonoid in oranges and grapefruit). Hesperidin is found in high concentration in fruit peel of oranges and in substantially lower concentration in juice of these fruits ...
Baghdad Science Journal
doaj   +1 more source

Hesperidin Interacts With CREB-BDNF Signaling Pathway to Suppress Pentylenetetrazole-Induced Convulsions in Zebrafish

Frontiers in Pharmacology, 2021
Hesperidin (3,5,7-trihydroxyflavanone 7-rhamnoglucoside) is a β-7-rutinoside of hesperetin (4′-methoxy-3′,5,7-trihydroxyflavanone), abundantly found in citrus fruits and known to interact with various cellular pathways to show a variety of ...
Pallavi Sharma, Pallavi Sharma, Savita Kumari, Savita Kumari, Jatin Sharma, Rituraj Purohit, Rituraj Purohit, Damanpreet Singh, Damanpreet Singh   +8 more
doaj   +1 more source