Results 111 to 120 of about 85,707 (260)

Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation [PDF]

, 2015
Verawan Boonsanay, Ting Zhang, Angelina M. Georgieva, Sawa Kostin, Hui Qi, Xuejun Yuan, Yonggang Zhou, Thomas Braun   +7 more
openalex   +1 more source

TGM2 Regulates Radiosensitivity via POGZ‐Mediated Repair of DNA Double‐Strand Breaks in Cervical Cancer

Cancer Science, EarlyView.
The present study revealed for the first time that TGM2 could regulate the radiosensitivity of cervical cancer via POGZ‐mediated DNA DSB repair. Our findings revealed that TGM2 regulates the radiosensitivity of cervical cancer and demonstrated that POGZ serves as a bridge linking TGM2 to the DNA damage repair process, and suggested a novel mechanistic ...
Yunbo Chi, Peng Dong, Ning Zhang, Baocai Liu, Qian Wang, Guanghui Cheng   +5 more
wiley   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair

Nature Communications
The CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1α, is enriched in heterochromatin though its cellular function in these regions of the genome remain unknown.
Feng Li, Tianpeng Zhang, Aleem Syed, Amira Elbakry, Noella Holmer, Huy Nguyen, Sirisha Mukkavalli, Roger A. Greenberg, Alan D. D’Andrea   +8 more
doaj   +1 more source

Nucleation and spreading of a heterochromatic domain in fission yeast

Nature Communications, 2016
Chromosomes contain large heterochromatin domains. Here, the authors measure the kinetics of heterochromatin formation in fission yeast and show both global and local feedbacks by nucleosome-bound enzymes are important for formation and stability of the ...
Michaela J. Obersriebnig, Emil M. H. Pallesen, Kim Sneppen, Ala Trusina, Geneviève Thon   +4 more
doaj   +1 more source

Guanine quadruplex structures localize to heterochromatin [PDF]

, 2017
Roland F. Hoffmann, Yuri M. Moshkin, Stijn Mouton, Nicola A. Grzeschik, Ruby D. Kalicharan, Jeroen Kuipers, Anouk H. G. Wolters, Kazuki Nishida, А. В. Ромащенко, Jan Postberg, Hans J. Lipps, Eugène Berezikov, Ody C.M. Sibon, Ben N. G. Giepmans, Peter M. Lansdorp   +14 more
openalex   +1 more source

Overcoming BET‐inhibitor JQ1 resistance in aggressive non‐small cell lung cancer by inducing ferroptosis via inhibition of the BRD2–FTH1 axis

The FEBS Journal, EarlyView.
Recent studies emphasize alternative functions of FTH1 relevant for nuclear processes, such as transcriptional regulation. This study shows a novel FTH1/BRD2 association in non‐small cell lung carcinoma (NSCLC). This nuclear interaction affects BRD2 protein stability in aggressive NSCLC cells.
Stefania Scicchitano, Cinzia Garofalo, Beatrice Stella, Gianluca Santamaria, Flora Cozzolino, Vittoria Monaco, Flavia Biamonte, Maria Monti, Eleonora Vecchio, Maria Concetta Faniello   +9 more
wiley   +1 more source

Mitotic Phosphorylation of Swi6/HP1 Regulates Its Chromatin Binding and Chromosome Segregation. [PDF]

FASEB J
Heterochromatin protein 1 (HP1) plays an important role in heterochromatin assembly. HP1 proteins undergo additional phosphorylation during mitosis. However, the functional significance of the mitotic phosphorylation of HP1 remains unclear. We identified mitotic phosphorylation sites within fission yeast Swi6 and showed that this phosphorylation is ...
Yoshimura Y, Hayashi A, Tanaka M, Suzuki-Matsubara M, Nakagawa R, Nishibuchi G, Tagami H, Oki M, Nakayama JI.   +8 more
europepmc   +2 more sources

THE STRUCTURE OF SALIVARY GLAND CHROMOSOMES OF DROSOPHILA MELANOGASTER IN EXCHANGES BETWEEN EUCHROMATIN AND HETEROCHROMATIN [PDF]

, 1940
Eileen Sutton
openalex   +1 more source

Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression

The FEBS Journal, EarlyView.
Genes repressed by the Polycomb system display greater chromatin folding compared to ‘regular’ inactive genes. The associated chromatin compaction, driven by PRC1‐H3K27me3 interactions, is modest and dynamic. This questions traditional models where Polycomb proteins repress transcription by sheltering genes from transcriptional activators.
Ludvig Lizana, Yuri B. Schwartz
wiley   +1 more source