Results 111 to 120 of about 124,493 (360)
Advanced Science, EarlyView.As an m6A reader, hnRNPA2B1 predominantly regulates specific transcripts (e.g., Ep400, Rrs1) that are essential for chromosome organization and remodeling in an m6A‐dependent manner. Furthermore, it is demonstrated to interact with factors involved in mRNA processing and translation. This dual functionality is pivotal for ensuring the proper occurrence
Lisha Yin +11 more
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Epigenetic aberrations and cancer [PDF]
, 2006 The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
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Heterochromatin and genetic conflict [PDF]
Proceedings of the National Academy of Sciences, 2016 Meiosis is a dangerous business. The two alleles in diploid organisms share an evolutionary interest in the survival and reproduction of their host individual; however, as soon as they segregate into haploid gametes, these alleles find themselves competing for transmission to the next generation (1).
openaire +3 more sources
Scientific ReportsHeterochromatin organization is critical to many genome-related programs including transcriptional silencing and DNA repair. While super-resolution imaging, electron microscopy, and multiomics methods have provided indirect insights into the ...
Rajshikhar Gupta +5 more
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Animal Models and Experimental Medicine, EarlyView.At steady state, DRG ensures low‐level expression of TH+ neurons under the protection of AKT. However, the DRG level of PD mouse model under MPTP toxicity increased significantly, and the expression of IL‐6 and CASP3 increased. This process was accompanied by the occurrence of m6A demethylation, with a significant increase in FTO as the main ...
Yatan Li +6 more
wiley +1 more source
CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair. [PDF]
Nat CommunThe CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1α, is enriched in heterochromatin though its cellular function in these regions of the genome remain unknown.
Li F +8 more
europepmc +2 more sources
Somatic Pairing in Drosophila virilis Mitosis [PDF]
, 1975 In neuroblast cells homologous chromosomes tend to pair during prophase of mitosis. Heterochromatic elements of homologous chromosomes are widely separated in very early prophase, at which time the euchromatin is poorly stained.
Guest, William C.
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Recent advances in malaria genomics and epigenomics [PDF]
, 2016 Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian +2 more
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A rosy future for heterochromatin. [PDF]
Proceedings of the National Academy of Sciences, 1994 The demonstration by Zhang and Spradling (1) of efficient P element transposition into heterochromatic regions will aid ongoing studies of heterochromatin structure and function. P element insertions will provide entry points for further molecular analysis of heterochromatin and will allow the isolation of small and large heterochromatic deficiencies ...
Gary H. Karpen, Kevin R. Cook
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Cells, 2020 The stability of pericentromeric heterochromatin is maintained by repressive epigenetic control mechanisms, and failure to maintain this stability may cause severe diseases such as immune deficiency and cancer.
Simone Johansen +1 more
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