Results 111 to 120 of about 73,923 (265)

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states

Cell Reports, 2021
Summary: Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle.
Magdalena Murawska, R.A. Greenstein, Tamas Schauer, Karl C.F. Olsen, Henry Ng, Andreas G. Ladurner, Bassem Al-Sady, Sigurd Braun   +7 more
doaj  

H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

bioRxiv, 2019
Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the
A. Poleshko, Cheryl L Smith, S. Nguyen, P. Sivaramakrishnan, J. Murray, M. Lakadamyali, E. Joyce, Rajan Jain, J. Epstein   +8 more
semanticscholar   +1 more source

CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation.

PLoS Biology
The densely packed centromeric heterochromatin at minor and major satellites is comprised of H3K9me2/3 histones, the heterochromatin protein HP1α, and histone variants.
Gokul Gopinathan, Qian Xu, Xianghong Luan, Thomas G H Diekwisch   +3 more
doaj   +1 more source

Active Hydrodynamic Theory of Euchromatin and Heterochromatin [PDF]

arXiv
The genome contains genetic information essential for cell's life. The genome's spatial organization inside the cell nucleus is critical for its proper function including gene regulation. The two major genomic compartments -- euchromatin and heterochromatin -- contain largely transcriptionally active and silenced genes, respectively, and exhibit ...
arxiv  

SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres

Science Advances, 2019
Atypical heterochromatin forms on telomeres and correlates with ALT activities. Alternative lengthening of telomeres, or ALT, is a recombination-based process that maintains telomeres to render some cancer cells immortal.
Mathilde Gauchier, Sophie Kan, Amandine Barral, Sandrine Sauzet, E. Agirre, Erin Bonnell, Nehmé Saksouk, T. Barth, Satoru Ide, S. Urbach, R. Wellinger, R. Luco, A. Imhof, J. Déjardin   +13 more
semanticscholar   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation.

Biochemistry, 2018
In eukaryotic cells, structures called heterochromatin play critical roles in nuclear processes ranging from gene repression to chromosome segregation. Biochemical and in vivo studies over the past several decades have implied that the diverse functions ...
A. Larson, G. Narlikar
semanticscholar   +1 more source

Two Types of Heterochromatin in Drosophila Nebulosa [PDF]

, 1946
C. Pavan
openalex   +1 more source

Epigenetic gene silencing by heterochromatin primes fungal resistance

Nature, 2019
Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders embedded genes transcriptionally silent1–3. In the fission yeast Schizosaccharomyces pombe, H3K9me heterochromatin can be transmitted through cell division provided the ...
Sito Torres-Garcia, Imtiyaz Yaseen, Manu Shukla, Pauline Audergon, S. White, A. Pidoux, R. Allshire   +6 more
semanticscholar   +1 more source

The Dual Roles of Lamin A/C in Macrophage Mechanotransduction

Cell Proliferation, EarlyView.
Compressive force can inhibit the expression of lamin A/C, SUN1 and SUN2 in macrophages. Lamin A deficiency may participate in mechanotransduction within macrophages through two distinct mechanisms. ABSTRACT Cellular mechanotransduction is a complex physiological process that integrates alterations in the external environment with cellular behaviours ...
Yao Wang, Sabine Ruf, Lei Wang, Thomas Heimerl, Gert Bange, Sabine Groeger   +5 more
wiley   +1 more source