Results 111 to 120 of about 102,928 (311)

Human cell recovery after microwave irradiation [PDF]

arXiv, 2009
Cells of human buccal epithelium of 6 male donors were exposed to microwave radiation (frequency f=36,64 GHz, power density E = 10, 100, and 400 mcW/cm^2). Exposure time in all experiments was 10 seconds. Heterochromatin was stained by 2% orcein in 45 % acetic acid. The stainability of cells with trypan blue (0,5 %) and indigocarmine (5 mM) after 5 min
arxiv  

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study [PDF]

, 2014
Background: Friedreich's ataxia is a progressive degenerative disorder caused by deficiency of the frataxin protein. Expanded GAA repeats within intron 1 of the frataxin (FXN) gene lead to its heterochromatinisation and transcriptional silencing ...
Athanasopoulos, Stavros, Chan, Ping Kei, Festenstein, Richard, Giunti, Paola, Huson, Les, Law, Pui Pik, Leiper, James, Libri, Vincenzo, Loyse, Naomi, Mauri, Marta, Mohammad, Tariq, Natisvili, Theona, Parkinson, Michael H, Piper, Sophie, Ramesh, Aravind, Tam, Kin Tung, Yandim, Cihangir   +16 more
core   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus

Nucleus
Abnormal cell nuclear shapes are hallmarks of diseases, including progeria, muscular dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin and increases in euchromatin lead to nuclear deformations, such as blebs and ...
Ali Goktug Attar, Jaroslaw Paturej, Edward J. Banigan, Aykut Erbaş   +3 more
doaj   +1 more source

A simulation model of heterochromatin formation at submolecular detail

iScience, 2022
Summary: Heterochromatin is a physical state of the chromatin fiber that maintains gene repression during cell development. Although evidence exists on molecular mechanisms involved in heterochromatin formation, a detailed structural mechanism of ...
Michael R. Williams, Yan Xiaokang, Nathaniel A. Hathaway, Dmitri Kireev   +3 more
doaj  

RNA from a simple-tandem repeat is required for sperm maturation and male fertility in Drosophila melanogaster. [PDF]

, 2019
Tandemly-repeated DNAs, or satellites, are enriched in heterochromatic regions of eukaryotic genomes and contribute to nuclear structure and function. Some satellites are transcribed, but we lack direct evidence that specific satellite RNAs are required ...
Allshire, Brown, Cai, Chen, Demarco, Dernburg, Ding, Eren-Ghiani, Ferree, Herbert, Hoskins, Hoskins, Jagannathan, Jain, Jandura, Jayaramaiah Raja, Johnson, Kaessmann, Kelemen, Kost, Larracuente, Legendre, Lohe, Lohe, McKee, McNulty, Ni, Nicholson, Pathak, Rathke, Rathke, Rinn, Rošić, Shirai, Shpiz, Steinhauer, Strom, Sun, Velazquez Camacho, Wei, White-Cooper, White-Cooper, Yap, Yuan, Zhu   +44 more
core   +2 more sources

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Hexavalents in spermatocytes of Robertsonian heterozygotes between Mus m. domesticus 2n 26 from the Vulcano and Lipari Islands (Aeolian Archipelago, Italy) [PDF]

, 2018
The size and shape of the chromosomes, as well as the chromosomal domains that compose them, are determinants in the distribution and interaction between the bivalents within the nucleus of spermatocytes in prophase I of meiosis.
Eliana Ayarza, Emanuela Solano, Ernesto Capanna, Jesús Page, Raúl Fernández-Donoso, Riccardo Castiglia, Soledad Berríos   +6 more
core   +3 more sources

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, EarlyView.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

The Emerging Roles of Heterochromatin in Cell Migration

Frontiers in Cell and Developmental Biology, 2020
Cell migration is a key process in health and disease. In the last decade an increasing attention is given to chromatin organization in migrating cells. In various types of cells induction of migration leads to a global increase in heterochromatin levels.
Gabi Gerlitz
doaj   +1 more source