Results 121 to 130 of about 85,707 (260)

Reorganization of H3K9me heterochromatin leads to neuronal impairment via the cascading destruction of the KDM3B-centered epigenomic network

iScience
Summary: Histone H3K9 methylated heterochromatin silences repetitive non-coding sequences and lineage-specific genes during development, but how tissue-specific genes escape from heterochromatin in differentiated cells is unclear.
Mi-Jin An, Ji-Young Kim, Jinho Kim, Dae-Hyun Kim, Geun-Seup Shin, Hyun-Min Lee, Ah-Ra Jo, Yuna Park, Yujeong Hwangbo, Chul-Hong Kim, Mi Jin Kim, Youn-Sang Jung, Jeongkyu Kim, Sangmyung Rhee, Sang-Beom Seo, Jung-Woong Kim   +15 more
doaj   +1 more source

Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin

Nature Biotechnology, 2021
Martina Tedesco, Francesca Giannese, D. Lazarević, Valentina Giansanti, D. Rosano, Silvia Monzani, Irene Catalano, Elena Grassi, E. Zanella, O. Botrugno, Leonardo Morelli, Paola Panina Bordignon, G. Caravagna, A. Bertotti, G. Martino, L. Aldrighetti, S. Pasqualato, L. Trusolino, Davide Cittaro, G. Tonon   +19 more
semanticscholar   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, EarlyView.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Variation of the centromeric heterochromatin region (CHR) in the Iranian house mouseMus musculusLinnaeus, 1758 (Rodentia: Muridae) [PDF]

, 2016
Farahnaz Molavi, Jamshid Darvish, Farhang Haddad, Maryam Moghaddam Matin   +3 more
openalex   +1 more source

Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition

The FEBS Journal, EarlyView.
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis, Abibe Useini, Heike Betat, Sonja Bonin, Helen Broghammer, Rima Nuwayhid, Stefan Langer, Mario Mörl, Norbert Sträter, John T. Heiker   +9 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair [PDF]

, 2011
Irene Chiolo, Aki Minoda, Serafin U. Colmenares, Aris Polyzos, Sylvain V. Costes, Gary H. Karpen   +5 more
openalex   +1 more source

Hop stunt viroid infection alters host heterochromatin [PDF]

, 2023
Joan Márquez‐Molins, Jinping Cheng, Julia Corell‐Sierra, Vasti Thamara Juárez-González, Pascual Villalba‐Bermell, María Luz Annacondia, Gustavo Gómez, Germán Martínez   +7 more
openalex   +1 more source

New insights into the putative XX/XY sex chromosomal system in blue‐eyed red‐fin pleco Hypostomus soniae (Siluriformes, Loricariidae)

Journal of Fish Biology, EarlyView.
Abstract Blue‐eyed red‐fin pleco Hypostomus soniae (family Loricariidae) presented a putative sex system XX/XY in early stage. Aiming to explore the inter‐populational karyotypic variation and proposed emergence of the XX/XY system, we studied 13 H. soniae individuals (6 males, 7 females) from the Tapajós River.
Luan Aércio Melo Maciel, Renata Coelho Rodrigues Noronha, Bruno Rafael Ribeiro de Almeida, Manoella Gemaque Cavalcante, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka, Luís Reginaldo R. Rodrigues   +6 more
wiley   +1 more source

Optimisation of freeze substitution protocols for the examination of malaria parasite structure by volumetric electron microscopy

Journal of Microscopy, EarlyView.
Abstract Malaria is one of the deadliest infectious diseases in the world, annually responsible for over 400,000 deaths. It is caused by parasites of the genus Plasmodium, which undergo remarkable structural changes during their development within different cells across various hosts.
Rachel Rachid, Camila Wendt, Wanderley de Souza, Kildare Miranda   +3 more
wiley   +1 more source