Results 121 to 130 of about 73,923 (265)
The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation
Nature Structural & Molecular Biology, 2019 The PIWI-interacting RNA (piRNA) pathway protects genome integrity in part through establishing repressive heterochromatin at transposon loci. Silencing requires piRNA-guided targeting of nuclear PIWI proteins to nascent transposon transcripts, yet the ...
Júlia Batki +12 more
semanticscholar +1 more source
Developmental Medicine &Child Neurology, EarlyView.Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale +14 more
wiley +1 more source
Nucleation and spreading of a heterochromatic domain in fission yeast
Nature Communications, 2016 Chromosomes contain large heterochromatin domains. Here, the authors measure the kinetics of heterochromatin formation in fission yeast and show both global and local feedbacks by nucleosome-bound enzymes are important for formation and stability of the ...
Michaela J. Obersriebnig +4 more
doaj +1 more source
A self-organised liquid reaction container for cellular memory [PDF]
arXivEpigenetic inheritance during cell division is essential for preserving cell identity by stabilizing the overall chromatin organisation. Heterochromatin,the condensed and transcriptionally silent fraction of chromatin,is marked by specific epigenetic modifications that are diluted during each cell division.
arxiv
Dynamics of BAF- Polycomb Complex Opposition on Heterochromatin in Normal and Oncogenic States
Nature Genetics, 2016 The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF) complexes has a critical role in both development and disease. Mutations in the genes encoding BAF subunits contribute to more than 20% of human malignancies, yet the ...
Cigall Kadoch +8 more
semanticscholar +1 more source
The FEBS Journal, EarlyView.The silencing of transposable elements is mediated by piRNAs through post‐transcriptional and transcriptional regulation. In Drosophila, piRNAs are processed within unique non‐membrane structures: nuage in germline cells and Yb bodies in somatic gonadal cells.
Ritsuko Suyama, Toshie Kai
wiley +1 more source
Versatile roles of disordered transcription factor effector domains in transcriptional regulation
The FEBS Journal, EarlyView.Disordered effector domains (EDs) of transcription factors (TFs) play versatile roles in transcriptional regulation. These include mediating protein–protein interactions with protein complexes like, facilitating condensate formation to enhance transcriptional efficiency, modulating DNA‐binding specificity through genome scanning, and serving as hubs ...
Rhea R. Datta +3 more
wiley +1 more source
HETEROCHROMATIN AND GENETIC ACTIVITY IN MEALY BUGS I. COMPENSATION FOR INACTIVE CHROMATIN BY INCREASE IN CELL NUMBER [PDF]
, 1968 Laurence Berlowitz +2 more
openalex +1 more source
The FEBS Journal, EarlyView.Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura +8 more
wiley +1 more source