Results 141 to 150 of about 124,493 (360)

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

bioRxiv, 2019
Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the
A. Poleshko, Cheryl L Smith, S. Nguyen, P. Sivaramakrishnan, J. Murray, M. Lakadamyali, E. Joyce, Rajan Jain, J. Epstein   +8 more
semanticscholar   +1 more source

Karyotypes and heterochromatin variation (C-bands) in Melipona species (Hymenoptera, Apidae, Meliponinae)

Genetics and Molecular Biology, 1998
We describe the karyotypes of eight bee species of the genus Melipona and compare them in terms of heterochromatin content and location (C-banding technique).
Marla Piumbini Rocha, Silvia das Graças Pompolo   +1 more
doaj   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair

Nucleus, 2019
Constitutive heterochromatin is considered as a functionally inert genome compartment, important for its architecture and stability. How such stable structure is maintained is not well understood.
Vadim O. Chagin, Britta Reinhart, Annette Becker, Oliver Mortusewicz, K. Laurence Jost, Alexander Rapp, Heinrich Leonhardt, M. Cristina Cardoso   +7 more
doaj   +1 more source

Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Cerebral tumors, particularly in pediatric patients, pose a significant challenge in oncology. Radiotherapy is a crucial component of the multimodal treatment approach for these tumors. Understanding the molecular basis of these tumors, particularly their response to radiotherapy, is crucial for improving treatment outcomes and patient ...
Ahana Maitra, Morena Miciaccia, Manuela Mandorino, Domenico Armenise, Olga Maria Baldelli, Savina Ferorelli, Ludmila Papusha, Alexander Druy, Maria Grazia Perrone, Antonio Scilimati   +9 more
wiley   +1 more source

The cell proliferation antigen Ki-67 organises heterochromatin

eLife, 2016
Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls heterochromatin organisation.
M. Sobecki, K. Mrouj, A. Camasses, N. Parisis, Emilien Nicolas, D. Llères, François Gerbe, S. Prieto, L. Krasinska, Alexandre David, M. Eguren, M. Birling, S. Urbach, S. Hem, J. Déjardin, Marcos Malumbres, P. Jay, V. Dulić, D. Lafontaine, R. Feil, D. Fisher   +20 more
semanticscholar   +1 more source

On the Heterogeneity of Heterochromatin

Caryologia, 1982
SUMMARY The properties of constitutive heterochromatin so far described, perhaps with the exception of the possibility of being C-banded, are not all common to all the species examined. The use of staining techniques or in vivo treatments makes it possible to demonstrate the existence of a marked heterogeneity of fractions of heterochromatin sometimes ...
openaire   +2 more sources

MTHFR promotes heterochromatin maintenance

Biochemical and Biophysical Research Communications, 2014
Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the folate cycle, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Methionine serves as the precursor of the active methyl donor S-adenosylmethionine, which provides methyl groups for many ...
Hongchang Zhao, Xingzhi Xu, Bin Peng, Bingtao Zhu, Heyu Zhao, Zhikai Xiahou   +5 more
openaire   +3 more sources

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source