Results 141 to 150 of about 133,661 (356)
Small Science, EarlyView.Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello +5 more
wiley +1 more source
Genetics and Molecular Biology, 1998 We describe the karyotypes of eight bee species of the genus Melipona and compare them in terms of heterochromatin content and location (C-banding technique).
Marla Piumbini Rocha +1 more
doaj +1 more source
bioRxiv, 2019 Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the
A. Poleshko +8 more
semanticscholar +1 more source
Aging Cell, EarlyView.We developed a human microglia aging model by doxycycline‐induced GFP‐progerin expression, which offers a valuable tool to study human microglial aging and its contribution to neurodegeneration. Induced HMC3‐Progerin cells exhibited increased age markers as well as transcriptomic alterations, including an age‐associated transcriptomic shift and ...
Christiane Hartmann +16 more
wiley +1 more source
Age‐Associated Transcriptomic and Epigenetic Alterations in Mouse Hippocampus
Aging Cell, EarlyView.Single‐nucleus multiome sequencing of hippocampus reveals aging‐dependent changes in gene expression and chromatin accessibility. Chromatin alterations in synaptic genes often occur without corresponding expression changes, suggesting a “susceptible” chromatin state.
Merve Bilgic +6 more
wiley +1 more source
Nucleus, 2019 Constitutive heterochromatin is considered as a functionally inert genome compartment, important for its architecture and stability. How such stable structure is maintained is not well understood.
Vadim O. Chagin +7 more
doaj +1 more source
Organ‐Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming
Aging Cell, EarlyView.Transient in vivo expression of Yamanaka factors (OSKM) enhances regenerative competence and rejuvenation across multiple tissues. We highlight mechanistic links between injury‐induced dedifferentiation and OSKM reprogramming, while emphasizing safety challenges and the need for precise spatiotemporal control to enable clinical translation.
Beom‐Ki Jo +4 more
wiley +1 more source
On the Heterogeneity of Heterochromatin
Caryologia, 1982 SUMMARY The properties of constitutive heterochromatin so far described, perhaps with the exception of the possibility of being C-banded, are not all common to all the species examined. The use of staining techniques or in vivo treatments makes it possible to demonstrate the existence of a marked heterogeneity of fractions of heterochromatin sometimes ...
openaire +2 more sources
MTHFR promotes heterochromatin maintenance
Biochemical and Biophysical Research Communications, 2014 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the folate cycle, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Methionine serves as the precursor of the active methyl donor S-adenosylmethionine, which provides methyl groups for many ...
Hongchang Zhao +5 more
openaire +3 more sources
The cell proliferation antigen Ki-67 organises heterochromatin
eLife, 2016 Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls heterochromatin organisation.
M. Sobecki +20 more
semanticscholar +1 more source