Results 151 to 160 of about 124,493 (360)

Two Types of Heterochromatin in Drosophila Nebulosa [PDF]

, 1946
C. Pavan
openalex   +1 more source

Proteomic Analysis of Bone Marrow CD138+ Cells to Identify Proteins Associated With the Response of Multiple Myeloma Patients to Commonly Used Therapeutic Regimens

PROTEOMICS, EarlyView.
ABSTRACT Multiple myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs’ resistance mechanisms are involved in the failure of therapies. This study aims to identify proteins significantly impacting MM patients’ response to commonly used therapeutic regimens.
Foteini Paradeisi, Aggeliki Tserga, Vasiliki Lygirou, Manousos Makridakis, Rafael Stroggilos, Grigoris Georgiou, George M. Spyrou, Ioannis V. Kostopoulos, Christine‐Ivy Liacos, Aikaterini Termentzi, Meletios A. Dimopoulos, Ourania Tsitsilonis, Antonia Vlahou, Efstathios Kastritis, Jerome Zoidakis   +14 more
wiley   +1 more source

The Extremely Low Mechanical Force Generated by Nano‐Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons

Small, EarlyView.
Nano‐pulling induces stabilization, reorganization, and reorientation of the microtubule network. The nucleus of stretched cells experiences increased lateral tension, becomes more spherical, and develops surface grooves. At the level of gene expression regulation, changes in nuclear morphology induce global chromatin remodeling, leading to reduced ...
Alessandro Falconieri, Lorenzo Da Palmata, Valentina Cappello, Tiziana Julia Nadjeschda Schmidt, Pietro Folino, Barbara Storti, Ranieri Bizzarri, Vittoria Raffa   +7 more
wiley   +1 more source

CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation.

PLoS Biology
The densely packed centromeric heterochromatin at minor and major satellites is comprised of H3K9me2/3 histones, the heterochromatin protein HP1α, and histone variants.
Gokul Gopinathan, Qian Xu, Xianghong Luan, Thomas G H Diekwisch   +3 more
doaj   +1 more source

MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line.

PLoS ONE, 2012
The X-linked Mecp2 is a known interpreter of epigenetic information and mutated in Rett syndrome, a complex neurological disease. MeCP2 recruits HDAC complexes to chromatin thereby modulating gene expression and, importantly regulates higher order ...
Bianca Bertulat, Maria Luigia De Bonis, Floriana Della Ragione, Anne Lehmkuhl, Manuela Milden, Christian Storm, K Laurence Jost, Simona Scala, Brian Hendrich, Maurizio D'Esposito, M Cristina Cardoso   +10 more
doaj   +1 more source

RepeatOBserver: Tandem Repeat Visualisation and Putative Centromere Detection

Molecular Ecology Resources, EarlyView.
ABSTRACT Tandem repeats play an important role in centromere structure, subtelomeric regions, DNA methylation, recombination and the regulation of gene activity. Analysis of their distribution in genomes offers a potential means for predicting putative centromere locations, which continues to be a challenge for genome annotation.
Cassandra Elphinstone, Rob Elphinstone, Marco Todesco, Loren H. Rieseberg   +3 more
wiley   +1 more source

SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres

Science Advances, 2019
Atypical heterochromatin forms on telomeres and correlates with ALT activities. Alternative lengthening of telomeres, or ALT, is a recombination-based process that maintains telomeres to render some cancer cells immortal.
Mathilde Gauchier, Sophie Kan, Amandine Barral, Sandrine Sauzet, E. Agirre, Erin Bonnell, Nehmé Saksouk, T. Barth, Satoru Ide, S. Urbach, R. Wellinger, R. Luco, A. Imhof, J. Déjardin   +13 more
semanticscholar   +1 more source

cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging

Aging Cell, EarlyView.
cTAGE5 regulates LBR trafficking between the ER and the nucleus membrane to maintain the integrity of both the ER and the nuclear envelope. cTAGE5 KO results in LBR retention in the ER, reduced stability, and subsequent disruption of nuclear envelope integrity. ABSTRACT cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER‐to‐Golgi trafficking,
Yaqing Wang, Pengyu Sun, Fuqiang Yang, Tiantian Ma, Junwan Fan, Lei Shi, Nan Li, Fei Gao, Kangmin He, Zhiheng Xu   +9 more
wiley   +1 more source

Metaphase Configurations in Drosophila: A Comparison of Endemic Hawaiian Species and Non-Endemic Species [PDF]

, 1976
The metaphase configurations of 400 strains from 63 species of Hawaiian Drosophila were determined from squash preparations of larval brain tissue or spermatogenic cells from adult testes.
Clayton, Frances E.
core   +2 more sources

Dynamics of BAF- Polycomb Complex Opposition on Heterochromatin in Normal and Oncogenic States

Nature Genetics, 2016
The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF) complexes has a critical role in both development and disease. Mutations in the genes encoding BAF subunits contribute to more than 20% of human malignancies, yet the ...
Cigall Kadoch, Robert T. Williams, Joseph P. Calarco, Erik L. Miller, Christopher M. Weber, S. Braun, John L. Pulice, Emma J. Chory, G. Crabtree   +8 more
semanticscholar   +1 more source