Results 151 to 160 of about 73,923 (265)

G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials

open access: yesMedicinal Research Reviews, Volume 45, Issue 3, Page 985-1015, May 2025.
ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis   +10 more
wiley   +1 more source

Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

open access: yesCell, 2003
M. Narita   +8 more
semanticscholar   +1 more source

The significance of PAX5 in Merkel cell carcinoma

open access: yesThe Journal of Pathology, Volume 266, Issue 1, Page 81-94, May 2025.
Abstract Merkel cell carcinoma (MCC) is a highly malignant skin cancer that expresses epithelial‐, neuroendocrine‐, and lymphoid‐associated genes. Here, we focused on B‐cell differentiation, which is characterised by the coexpression of PAX5 and TdT. PAX5 is the master regulator of B‐cell commitment and is expressed in 65% of MCC cases.
Emil Chteinberg   +16 more
wiley   +1 more source

Sequence-directed curvature of repetitiveAluIDNA in constitutive heterochromatin ofArtemia franciscana [PDF]

open access: bronze, 1989
Roberta Benfante   +3 more
openalex   +1 more source

Effects of Thermal Manipulation and Serotonin Modulation on Brain HSP70 and HSP90 Gene Expression in Late Embryogenesis of Broilers

open access: yesVeterinary Medicine and Science, Volume 11, Issue 3, May 2025.
This study is the first to report decreased gene expression of brain HSP70 and HSP90 in late embryogenesis of Ross broiler under heat stress, with serotonin serving as an anti‐stress agent by promoting HSP gene expression. ABSTRACT Introduction Broiler chickens are particularly vulnerable to elevated temperatures compared to mammals because they have ...
Hamed KHasti   +4 more
wiley   +1 more source

Aerobic exercise improves astrocyte mitochondrial quality and transfer to neurons in a mouse model of Alzheimer's disease

open access: yesBrain Pathology, Volume 35, Issue 3, May 2025.
Aerobic exercise improves transfer of healthy mitochondria from astrocytes to neurons in the 5 × FAD mice. Abstract Mitochondrial dysfunction is a well‐established hallmark of Alzheimer's disease (AD). Despite recent documentation of transcellular mitochondrial transfer, its role in the pathogenesis of AD remains unclear.
Jiachen Cai   +10 more
wiley   +1 more source

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