Results 151 to 160 of about 85,707 (260)
Glia, Volume 74, Issue 1, January 2026.Astrocytic ATRX loss causes non‐cell‐autonomous neuronal hyperexcitability. Inducing ATRX deficiency in astrocytes causes selective long‐term memory deficits. Dynamic transcriptomic changes reveal metabolic and synaptic pathway dysregulation. ABSTRACT Astrocytes are increasingly recognized as active regulators of synaptic transmission and memory, yet ...
Miguel A. Pena‐Ortiz +6 more
wiley +1 more source
Linking replication stress with heterochromatin formation [PDF]
, 2015 Ivaylo Nikolov, Angela Taddei
openalex +1 more source
Female Patients With Mucopolysaccharidosis II (MPS II): Insights From the Hunter Outcome Survey
JIMD Reports, Volume 67, Issue 1, January 2026.ABSTRACT Mucopolysaccharidosis II is a rare, X‐linked disease, with very few reports of affected female patients. Natural history data describe a predominantly male population, and appropriate disease characterization in female patients is lacking. This analysis explores the somatic disease burden and clinical progression of female patients with MPS II
Barbara K. Burton +10 more
wiley +1 more source
Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression
Cell, 2017 B. Steensel, A. Belmont
semanticscholar +1 more source
Diploid origins and early genome stabilization in the allotetraploid Arabidopsis suecica
New Phytologist, Volume 249, Issue 1, Page 524-538, January 2026.Summary Polyploidization, followed by genome downsizing, is a recurrent evolutionary cycle that dramatically reshapes genome structure. Newly formed polyploids must quickly adjust their cell division machinery to maintain stable chromosome inheritance, while long‐term stabilization involves rediploidization, returning the genome to a diploid‐like state.
Robin Burns +6 more
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 1, Page 450-473, January 2026.ABSTRACT Glucosinolates (GSLs) are secondary metabolites central to plant defence in the Brassicaceae family. While the role of histone modifications in developmental gene regulation is well studied, their function in stress‐induced secondary metabolism remains unclear.
Dasom Choi +2 more
wiley +1 more source
Ten principles of heterochromatin formation and function
Nature reviews. Molecular cell biology, 2017 R. Allshire, H. Madhani
semanticscholar +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.A novel chromatin‐labeling probe is developed to investigate chromatin mobility during differentiation. The silicon rhodamine–conjugated dCTP is efficiently delivered into iPSCs and NSCs using a synthetic transporter. Super‐resolution microscopy and single‐particle tracking show decreased chromatin mobility during differentiation.
Maruthi K. Pabba +11 more
wiley +1 more source
UHRF1 Controls the Timing of RAD51 Removal During DNA Damage Repair Through Suppressing RFWD3
Advanced Science, Volume 12, Issue 45, December 4, 2025.We demonstrate here that the recombinase RAD51 is protected by UHRF1 through ubiquitinating RFWD3, an E3 for RAD51, and this very process is inhibited by RAD51, leading to a triple negative feedback circuit that ensures appropriate levels of RFWD3 and RAD51 for DNA damage response. Abstract The RAD51 recombinase is evolutionarily conserved critical for
Guangxue Liu +4 more
wiley +1 more source