Results 201 to 210 of about 102,928 (311)

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

open access: yesAdvanced Science, Volume 12, Issue 21, June 5, 2025.
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun   +13 more
wiley   +1 more source

Constitutive heterochromatin distribution in pig (Sus scrofa) chromosomes [PDF]

open access: bronze, 1998
G.P. Di Meo   +5 more
openalex   +1 more source

Confined Migration Drives Stem Cell Differentiation

open access: yesAdvanced Science, Volume 12, Issue 21, June 5, 2025.
Human mesenchymal stem cell (hMSC) homing to sites of regeneration requires navigation through mechanically confining extracellular matrix environments, inducing rapid and dramatic morphological adaptation. By exposing hMSCs to specific levels of physiological confinement, it is demonstrated that confinement can induce osteogenesis, and that this fate ...
Xu Gao   +6 more
wiley   +1 more source

Epigenetic Histone Deacetylases Activity Assay in the Brain and Peripheral Organ Tissues

open access: yesCurrent Protocols, Volume 5, Issue 6, June 2025.
Abstract Histone deacetylases (HDACs) are crucial epigenetic regulators involved in the modulation of gene expression and are promising therapeutic targets for treating various diseases, including central nervous system disorders and cancer. HDAC inhibitors exhibit neuroprotective, antiepileptogenic, and antidepressant properties in animal models ...
Doodipala Samba Reddy   +5 more
wiley   +1 more source

DDM1 Maintains Heterochromatin by Regulating Histone Variants. [PDF]

open access: yesInt J Mol Sci
Sun Y   +5 more
europepmc   +1 more source

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