Results 1 to 10 of about 169,654 (276)
Pharmaceutics, 2023 Five-membered heterocycles are essential structural components in various antibacterial drugs; the physicochemical properties of a five-membered heterocycle can play a crucial role in determining the biological activity of an antibacterial drug.
Aura Rusu +3 more
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Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis
Nature Communications, 2020 Heterocycles containing difluoromethyl groups are molecules with potential application in pharmaceutical, agricultural and materials science. Here, the authors show an organophotocatalytic difluoromethylation of heterocycles using O2 as green oxidant and
Wei Zhang +7 more
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Prescribed drugs containing nitrogen heterocycles: an overview
RSC Advances, 2020 Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in a plethora of active pharmaceuticals natural products.
Majid M Heravi, Majid M Heravi
exaly +2 more sources
Nature Communications, 2021 Enantioenriched medium-sized silicon-stereogenic heterocycles are in high demand due to the potential use in functional materials. Here, the authors show a rhodium-catalyzed enantioselective synthesis of six- and seven-membered tri-organosubstituted ...
Shuyou Chen +5 more
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Late-stage functionalization of BN-heterocycles
Chemical Society Reviews, 2019 BN/CC isosterism has emerged as a viable strategy to expand the chemical space of organic molecules. In particular, the application of BN/CC isosterism to arenes has received significant attention due to the vast available chemical space provided by ...
Cameron R Mcconnell, Shih-yuan Liu
exaly +2 more sources
Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective
Pharmaceuticals, 2023 Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance.
Adarsh Kumar +14 more
semanticscholar +1 more source
Molecules, 2022 We here have developed an S(O)2–N coupling between phenylsulfinic acid derivatives and aryl azides by dual copper and visible light catalysis. In this efficient and mild pathway, the reaction produces sulfonamide compounds under redox-neutral condition ...
Zhipeng Liang, Ya-Nan Wu, Yang Wang
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Insertion of ammonia into alkenes to build aromatic N-heterocycles
Nature Communications, 2022 Ammonia is one of the most abundant and simple nitrogen sources with decent stability and reactivity. Direct insertion of ammonia into a carbon skeleton is an ideal approach to building valuable N -heterocycles for extensive applications with ...
Shuai Liu, Xu Cheng
semanticscholar +1 more source
Molecules, 2021 Coumarins are natural heterocycles that widely contribute to the design of various biologically active compounds. Fusing different aromatic heterocycles with coumarin at its 3,4-position is one of the interesting approaches to generating novel molecules ...
Eslam Reda El-Sawy +2 more
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A Review on The Medicinal And Industrial Applications of N-Containing Heterocycles
Open Medicinal Chemistry Journal, 2022 Nitrogen-containing heterocycles constitute an important division of organic chemistry. The structural and functional diversity in nitrogen-containing heterocyclic compounds emanates from the presence and nature of the heteroatom that optimizes the ...
Andleeb Amin +4 more
semanticscholar +1 more source