Results 151 to 160 of about 169,803 (413)

Synthetic utility and reactivity of N-alkynylazoles [PDF]

, 2015
textThe chemistry of N-alkynylazoles is a newly emerging area of chemistry with particular interest in heterocycle synthesis. Synthetic preparations of this class of molecule have shown an increasing presence in literature, however, the synthetic ...
Gilbreath, Bradford Lynd
core  

Binding of Carminomycin to synthetic polyribonucleotides poly(A) and poly(U): absorption and polarized fluorescence study [PDF]

Biophysical Bulletin 488(1)(2000)56-59.(in Ukrainian), 2020
Binding of anthracycline antibiotic carminomycin (CM) to synthetic polyribonucleotides poly(A) and poly(U) was studied in solution of low ionic strength in a wide phosphate-to-dye (P/D) range using absorption and polarized fluorescence spectroscopy. Two different modes of CM binding to the ss-polynucleotides have been identified.
arxiv  

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

Iridium-Catalyzed Hydrogenation and Dehydrogenation of N-Heterocycles in Water under Mild Conditions.

ChemSusChem, 2019
An efficient catalytic method is presented for the hydrogenation of N-heterocycles. The iridium-based catalyst operates under mild conditions in water without any co-catalyst or stoichiometric additives. The catalyst also promotes the reverse reaction of
Shengdong Wang, Haiyun Huang, C. Bruneau, C. Fischmeister   +3 more
semanticscholar   +1 more source

Comprehensive Organic Analysis of Antartic Micrometeorites [PDF]

, 2008
Introduction: Micrometeorites (MMs) are thought to be significant contributors of organic material to the early Earth [1], and a variety of techniques have been employed to identify their organic composition [2-6]. These include the identification of key
Dobrica, E., Gilmour, I., Pearson, V. K., Turner, D. C., Wilson, R. C.   +4 more
core  

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Visible light mediated intermolecular [3 + 2] annulation of cyclopropylanilines with alkynes

Beilstein Journal of Organic Chemistry, 2014
Intermolecular [3 + 2] annulation of cyclopropylanilines with alkynes is realized using visible light photoredox catalysis, yielding a variety of cyclic allylic amines in fair to good yields.
Theresa H. Nguyen, Soumitra Maity, Nan Zheng   +2 more
doaj   +1 more source

Antagonist Targeting the Species‐Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti‐H. pylori Infection

Advanced Science, EarlyView.
This study demonstrates that the atypical dehydrogenase/isomerase FabX in Type‐II fatty acid biosynthesis pathway is essential for H. pylori infection by retaining unsaturated fatty acid synthesis and producing superoxide (ROS). A small molecule FBX‐1991 that specifically targets FabX to inhibit H.
Lin Zhang, Xiaoxue Ruan, Xudong Hang, Ding Heng, Chang Cai, Liping Zeng, Guoxin Zhang, Lu Zhou, Hongkai Bi, Liang Zhang   +9 more
wiley   +1 more source

THE CONDENSATION OF SUCCINYLOSUCCINIC ACID DIETHYL ESTER WITH GUANIDINE. A DERIVATIVE OF 1,3,5,7-NAPHTTETRAZINE, A NEW HETEROCYCLE.¹ [PDF]

, 1905
Marston Taylor Bogert, Arthur W. Dox
openalex   +1 more source

A General Strategy for C(sp3)─H Bond Etherification via Quinoline Derivative‐Mediated Electrolysis

Advanced Science, EarlyView.
A quinoline‐based mediator is introduced for the electrochemical etherification of C(sp3)─H bonds, enabling the process with minimal dependence on substrate electronic properties. The reaction demonstrates compatibility with various C─H bonds, including tertiary benzylic C─H bonds and unactivated C(sp3)─H bonds.
Yousen Xu, Hao Wu, ChenXi Zhu, Minjun Tu, Lei Zhang   +4 more
wiley   +1 more source