Results 11 to 20 of about 169,803 (413)
Heterocycles in Medicinal Chemistry [PDF]
Molecules, 2019 Heteroatoms constitute a very common fragment of a number of active pharmaceutical ingredients as well as excipients; from the point of view of significance, it is all the same if these are isosterically/bioisosterically replaced carbons/carbon ...
J. Jampílek
semanticscholar +4 more sources
Photomediated ring contraction of saturated heterocycles
Science, 2021 Shuffling nitrogen with a light push Manipulation of carbon–nitrogen rings is integral to the synthesis of numerous pharmaceutical and agrochemical compounds. Jurczyk et al.
Justin Jurczyk +6 more
semanticscholar +1 more source
Cycloadditions of cyclohexynes and cyclopentyne. [PDF]
, 2014 We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described.
Garg, Neil K +4 more
core +6 more sources
Pharmaceuticals, 2021 A new series of twenty-two C-5 substituted N-arylsulfonylindoles was prepared with the aim of exploring the influence of C-5 substitution on 5-HT6 receptor affinity. Eleven compounds showed moderate to high affinity at the receptor (Ki = 58–403 nM), with
Loreto Arrieta-Rodríguez +8 more
doaj +1 more source
Heterocyclic Electrochemistry: Renewable Electricity in the Construction of Heterocycles
ACS Omega, 2023 Numerous applications in the realm of biological exploration and drug synthesis can be found in heterocyclic chemistry, which is a vast subject. Many efforts have been developed to further improve the reaction conditions to access this interesting family to prevent employing hazardous ingredients.
Samina Aslam +5 more
openaire +3 more sources
Charge Migration in Heterocyclic Five-Membered Rings [PDF]
, 2023 This contribution presents numerical simulations of N-electron dynamics in heterocyclic five-membered ring molecules to shed light on the effect of molecular symmetry on charge migration. Laser-driven dynamics is studied using the hybrid time-dependent density functional theory/configuration methodology, and the ensuing field-free charge migration is ...
arxiv +1 more source
Structure and Stability of Aromatic Nitrogen Heterocycles Used in the Field of Energetic Materials
Molecules, 2020 Understanding the stabilization of nitrogen heterocycles is critical in the field of energetic materials and calls for innovative knowledge of nitrogen aromatics.
He-Hou Zong +4 more
doaj +1 more source
optimizing the searches for interstellar heterocycles [PDF]
, 2021 It is a fact that interstellar formation processes are thermodynamically affected. Based on this, the seven heterocycles; imidazole, pyridine, pyrimidine, pyrrole, quinoline, isoquinoline and furan that have been searched for from different astronomical sources with only upper limits of their column density determined without any successful detection ...
arxiv +1 more source
Synthesis of Phosphorus(V)-Substituted Six-Membered N-Heterocycles: Recent Progress and Challenges
Molecules, 2023 Heterocycles functionalized with pentavalent phosphorus are of great importance since they include a great variety of biologically active compounds and pharmaceuticals, advanced materials, and valuable reactive intermediates for organic synthesis ...
Yulia Volkova, Igor Zavarzin
doaj +1 more source
Molecules, 2020 Aromatic heterocycles are ubiquitous building blocks in bioactive natural products, pharmaceutical and agrochemical industries. Accordingly, the carborane-fused heterocycles would be potential candidates in drug discovery, nanomaterials ...
Ke Cao +7 more
doaj +1 more source