Results 81 to 90 of about 128,452 (331)

Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors [PDF]

, 2011
With the aim to develop novel HIV-1 integrase inhibitors, we obtained a set of condensed ring systems based on the furo[2,3-h]cinnolin-3(2H)-one and pyridazino[3,4-f]cinnolin-3-ol scaffolds bearing a potential chelating pharmacophore, which can be ...
Casule, Paola, Derudas, Marco, El-Tamany, El-Sayed H, Gomaa, Mohamed F Y, Hasanen, Jehan Abd-Elrazik, Mariani, Alberto, Pala, Nicolino, Sechi, Mario   +7 more
core   +1 more source

Harnessing Carbenoid Reactivity From Imidazoles and Oxiranes

Advanced Synthesis &Catalysis, EarlyView.
The combination of azole compounds and oxiranes exhibits carbenoid reactivity at elevated temperatures, as demonstrated by the successful benzoin condensation of aromatic aldehydes. Using this catalytic system to polymerize bifunctional aldehyde/oxirane monomers yields thermosets with glass transition temperatures above 100°C.
Matthias R. Steiner, Johanna M. Uher, Jürgen Lindner, Cordula M. Zeiler, Christian Slugovc   +4 more
wiley   +1 more source

Synthesis of pyrrolo[1,2-a]indole-1,8(5H)-diones as new synthons for developing novel tricyclic compounds of pharmaceutical interest [PDF]

, 2004
In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, a new tricycle, the tetrahydropyrrolo[1,2-a]indole-1,8-dione, has been synthesized by an intramolecular Friedel-Crafts acylation, as a synthon suitable to be ...
Mura, Alessio, Orecchioni, Maria, Paglietti, Giuseppe, Sannia, Luciano, Sechi, Mario   +4 more
core  

Synthesis and (spectro)electrochemistry of mixedvalent diferrocenyl–dihydrothiopyran derivatives [PDF]

, 2015
Three novel diferrocenyl complexes were prepared and characterised. 2,2-Diferrocenyl-4,5-dimethyl- 3,6-dihydro-2H-thiopyran (1, sulphide) was accessible by the hetero-Diels–Alder reaction of diferrocenyl thioketone with 2,3-dimethyl-1,3-butadiene ...
Aguirre-Etcheverry, Alexander Hildebrandt, Allen, Barlow, Barrière, Barrière, Becke, Bruno Therrien, Ceccon, Costuas, D'Alessandro, Delgado-Pena, Denifl, Diallo, Diallo, Dominique Miesel, Dong, Dong, Drabowicz, Duggan, Enders, Farrugia, Ferguson, Filipczyk, Fourie, Geiger, Geiger, Gericke, Glover, Gray, Gritzner, Grzegorz Mlostoń, Heinrich Lang, Hildebrandt, Hildebrandt, Hildebrandt, Hildebrandt, Hildebrandt, Hush, Inamoto, Jones, Kaleta, Kaleta, Kienz, Konrad Kowalski, Kotz, Kowalski, Kowalski, Krejcik, Lapinte, Larsen, Lee, Lehrich, Linseis, Lohan, Lohan, Miesel, Mücke, Nafady, Nemykin, Nemykin, O'Connor Salazar, Paul, Petrov, Petrov, Pfaff, Pfaff, Pfaff, Pfaff, Pichlmaier, Poppitz, Rafał Czerwieniec, Rafał Karpowicz, Ratner, Ribou, Robin, Rulkens, Sheldrick, Snyder, Speck, Speck, Swarts, Ward, Weeb, Winter, Xie, Xie, Yamaguchi   +87 more
core   +3 more sources

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Polyoxometalate catalysts for the synthesis of N-heterocycles

Polyoxometalates
N-Heterocycle compounds are crucial scaffolds in natural products, synthetic molecules, agricultural chemicals, and pharmaceuticals. Hence, green catalytic systems for the synthesis of N-heterocycles have been widely researched in organic synthesis and ...
Qilong Hu, Ke Li, Xuejiao Chen, Yufeng Liu, Guoping Yang   +4 more
doaj   +1 more source

Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities

Results in Chemistry, 2020
A greener strategy for the synthesis of some functionalized heterocycles have been developed using Sonogashira cross-coupling reaction of furfural derived isoxazolidine and isoxazoline derivatives.
Bhaskar Chakraborty, Esmita Chettri
doaj   +1 more source

Photochemistry of N-(selenoalkyl)-phthalimides. Formation of N, Se-heterocyclic systems [PDF]

, 2015
A variety of N-(selenomethyl)alkyl-phthalimides (alkyl = -(CH2)n-; n = 2-5, 1a, b, d, e) and N-(selenobenzyl)propyl phthalimide (1c) were synthesized and their photochemistry was studied at λ = 300 nm.
Argüello, Juan Elias, Heredia, Adrián Alberto, Oksdath Mansilla, Gabriela, Peñeñory, Alicia Beatriz   +3 more
core   +1 more source

Coupling Nitrogenous Organic Wastewater Treatment and Biorefinery via N‐Cycling Bacterium

Advanced Science, EarlyView.
The vast reservoir of nitrogenous organic pollutants in industrial wastewaters can serve as untapped carbon‐nitrogen resources. This study employs the newly discovered Paracoccus sp. ZQW‐1 as a versatile chassis to simultaneously achieve N‐methylpyrrolidone (NMP) wastewater depuration and polyhydroxybutyrate (PHB) synthesis.
Ziqian Wang, Chunyu Du, Guanyu Zheng, Dahu Ding   +3 more
wiley   +1 more source

Reactivity and Stability of (Hetero)Benzylic Alkenes via the Wittig Olefination Reaction

Molecules
Wittig olefination at hetero-benzylic positions for electron-deficient and electron-rich heterocycles has been studied. The electronic effects of some commonly used protective groups associated with the N-heterocycles were also investigated for alkenes ...
Ajmir Khan, Mohammed G. Sarwar, Sher Ali
doaj   +1 more source