Results 11 to 20 of about 214 (132)

Muribaculum intestinale-derived 3-hydroxybutyric acid from Heterophyllin B attenuated pulmonary fibrosis through IDO1-mediated ferroptosis

Pharmacological Research
Pulmonary fibrosis (PF) is a fatal disease with increasing incidence, poor prognosis, and unclear pathogenesis. Our previous research demonstrated the beneficial effects of the natural cyclopeptide Heterophyllin B (HB) in PF.
Ce Chen, Jialin Wang, Mengqin Cheng, Haifeng Xie, Wei Li, Chaofeng Zhang   +5 more
doaj   +3 more sources

Review of the ethnobotany, phytochemistry, pharmacology, and toxicity studies of the genus <i>Adenia</i>. [PDF]

Front Pharmacol
BackgroundThe genus Adenia has a rich history of traditional medicinal use across various cultures, particularly in Africa and parts of Asia. The present review summarizes key features of the genus Adenia, focusing on its occurrence, distribution ...
Mouafon IL, Katerere DR.
europepmc   +3 more sources

Natural products for anti-fibrotic therapy in idiopathic pulmonary fibrosis: marine and terrestrial insights. [PDF]

Front Pharmacol
Idiopathic Pulmonary Fibrosis (IPF) is a chronic fibrotic interstitial lung disease (ILD) of unknown etiology, characterized by increasing incidence and intricate pathogenesis.
Ma M, Chu Z, Quan H, Li H, Zhou Y, Han Y, Li K, Pan W, Wang DY, Yan Y, Shu Z, Qiao Y.   +11 more
europepmc   +3 more sources

太子参环肽B(Heterophyllin B, HB)的酶环化反应 [PDF]

Science in China Series B-Chemistry (in Chinese), 2005
利用从 Pseudostellaria heterophylla 提取分离的粗酶PH-1, 以链八肽NH 2 -Gly 1 -Gly 2 -Leu-Pro-Pro-Pro-Ile-Phe-COOH (4)为底物成功地进行了太子参环肽B(heterophyllin B (HB))的环化反应, 并利用TLC, HPLC, M, NMR以及同位素标记等手段对反应产物进行了分析和确证.
俊 周, 宁华 谭, 小烛 刘, 月毛 沈, 湘 李, 爱群 贾   +5 more
core   +2 more sources

Heterophyllin B inhibits the malignant phenotypes of gastric cancer cells via CXCR4

Human Cell, 2022
Heterophyllin B (HB) is a cyclic lipopeptide that has been shown to have anticancer effects. This study intended to further explore the effects and modulatory mechanism of HB in gastric cancer (GC) cells. The binding relationship between HB and CXCR4 was investigated by network pharmacological analysis, molecular docking, and cellular thermal shift ...
Jianing Tang, Jinyu Zhang, Lei Yin, Xiaofeng Yu, Yuhai Gao, Yunhai Wei, Zhongxin Wu   +6 more
core   +3 more sources

Comparison of Chemical Compositions in Pseudostellariae Radix from Different Cultivated Fields and Germplasms by NMR-Based Metabolomics

Molecules, 2016
Pseudostellariae Radix (PR) is an important traditional Chinese medicine (TCM), which is consumed commonly for its positive health effects. However, the chemical differences of PR from different cultivated fields and germplasms are still unknown.
Yujiao Hua, Ya Hou, Shengnan Wang, Yang Ma, Zixiu Liu, Lisi Zou, Xunhong Liu, Yiyuan Luo, Juanxiu Liu   +8 more
doaj   +3 more sources

Paclobutrazol suppresses the synthesis of key secondary metabolites by antagonizing gibberellin signaling in Pseudostellaria heterophylla

Biomedical Chromatography, 2023
Background：Pseudostellaria heterophyllais one of the most well-known traditional Chinese medicines, and its secondary metabolites play an important medicinal role.
Changgui Yang, Chen Zhang, Chenghong Xiao, Jiao Xu, Jinqiang Zhang, Liangyuan Li, Qingsong Yuan, Tao Zhou, Taosheng Wu, Zhen Ouyang   +9 more
core   +4 more sources

Host heterogeneity in humoral bactericidal activity can be complement independent. [PDF]

Front Immunol
BackgroundHumoral bactericidal activity was first recognized nearly a century ago. However, the extent of inter-individual heterogeneity and the mechanisms underlying such heterogeneity beyond antibody or complement systems have not been well studied ...
Abe R, Ram-Mohan N, Zudock EJ, Lewis S, Carroll KC, Yang S.   +5 more
europepmc   +3 more sources

Identification and expression analysis of R2R3-MYB transcription factor in Pseudostellaria heterophylla

Guangxi Zhiwu
R2R3-MYB transcription factor plays an important role in plant growth and development, stress response, and secondary metabolism. In order to explore the temporal and spatial expression pattern of R2R3-MYB transcription factors in Pseudostellaria ...
HUANG Yishu, HE Hua, ZHOU Tao, PAN Qi, LIU Hongxia, XU Jiao, OU Xiaohong, JIANG Weike*
doaj   +2 more sources

Harnessing nature's pharmacy: investigating natural compounds as novel therapeutics for ulcerative colitis. [PDF]

Front Pharmacol
BackgroundsUlcerative colitis (UC) is a form of chronic inflammatory bowel disease, and UC diagnosis rates continue to rise throughout the globe. The research and development of new drugs for the treatment of UC are urgent, and natural compounds are an ...
Huang Y, Wu Q, Li S, Lin X, Yang S, Zhu R, Fu C, Zhang Z.   +7 more
europepmc   +3 more sources