Results 51 to 60 of about 2,645,999 (191)

TARGETS FOR MAJORITY OF DRUGS: G PROTEIN-COUPLED RECEPTORS - THEIR STRUCTURE AND INTERACTIONS WITH BIOLIGANDS

TASK Quarterly, 2021
G protein-coupled receptors (GPCRs) are the most frequent targets for many drugs. They form the largest superfamily of integral membrane proteins, of which more than 1000 members have the following common features: (i) All GPCRs form 7 hydrophobic a ...
JERZY CIARKOWSKI, CEZARY CZAPLEWSKI, MARTA PASENKIEWICZ-GIERULA   +2 more
doaj  

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

The Role of G Protein Alpha Subunits in the Infection Process of the Gray Mold Fungus Botrytis cinerea

Molecular Plant-Microbe Interactions, 2001
To identify signal transduction pathways of the gray mold fungus Botrytis cinerea involved in host infection, we used heterologous hybridization and a polymerase chain reaction (PCR)-based approach to isolate two genes (bcg1 and bcg2) encoding α subunits
Christian Schulze Gronover, Daniela Kasulke, Paul Tudzynski, Bettina Tudzynski   +3 more
doaj   +1 more source

RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation

Cancer Science, Volume 117, Issue 8, Page 2194-2207, August 2026.
RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu, Gang Yu, Yuan Liu, Yu Zhou, Wei Liu, Lin Wang, Lide Liu, Yan Liu, Tiejun Pan, Zhenyu Liu, Lei Gao   +10 more
wiley   +1 more source

SIÇAN BEYİN G PROTEİNLERİNİN KARAKTERİZASYONU

Cerrahpaşa Medical Journal, 2014
Background and Design.- Heterotrimeric guanine nucleotide binding protein (G proteins) play a central role in regulation of signal transmission in the cell. G proteins which are localized in the inner surface of the cell membrane consist of α-, β- and γ-
Hülya CABADAK, Beki KAN
doaj  

G-protein β subunit AGB1 positively regulates salt stress tolerance in Arabidopsis

Journal of Integrative Agriculture, 2015
The heterotrimeric GTP-binding proteins (G-proteins) in eukaryotes consisted of α, β and γ subunits and are important in molecular signaling by interacting with G-protein-coupled receptors (GPCR), on which to transduce signaling into the cytoplast ...
Ya-nan MA, Ming CHEN, Dong-bei XU, Guang-ning FANG, Er-hui WANG, Shi-qing GAO, Zhao-shi XU, Lian-cheng LI, Xiao-hong ZHANG, Dong-hong MIN, You-zhi MA   +10 more
doaj   +1 more source

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

, 2011
GTPases act as molecular switches to control many cellular processes, including signalling, protein translation and targeting. Switch activity can be regulated by external effector proteins or intrinsic properties, such as dimerization.
Ivo Tews, Patrick Koenig, Danny J. Schnell, Tews, Ivo, Sinning, Irmgard, Enrico Schleiff, Oreb, Mislav, Schnell, Danny, Koenig, Patrick, Mislav Oreb, Maik S. Sommer, Sommer, Maik S, Wang, Fei, Schnell, Danny J., Schleiff, Enrico, Irmgard Sinning, Sommer, Maik S., Fei Wang, Anja Höfle, Höfle, Anja   +19 more
core   +1 more source

Ga and Gß Proteins Regulate the Cyclic AMP Pathway That Is Required for Development and Pathogenicity of the Phytopathogen Mycosphaerella graminicola [PDF]

, 2009
We identified and functionally characterized genes encoding three G alpha proteins and one G beta protein in the dimorphic fungal wheat pathogen Mycosphaerella graminicola, which we designated MgGpa1, MgGpa2, MgGpa3, and MgGpb1, respectively.
Lee, T.A.J., van der, Wit, P.J.G.M., de, Kema, G.H.J., M'Barek, S., Ben, Waalwijk, C., Mehrabi, A.   +5 more
core   +1 more source

Plant G proteins: Versatile signaling hubs for synergistic improvement of agronomic traits

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 3133-3152, August 2026.
This review highlights the roles of G‐protein signaling in crop yield and quality, as well as abiotic and biotic stress responses. It also discusses the feasibility of breaking the trade‐off between plant growth and stress tolerance via dissecting G‐protein regulatory pathways, gene editing, mining natural elite variants, and AI‐assisted breeding ...
Haoran Li, Zhilong Zhang, Fangyuan Liu, Haonan Wang, Zebiao He, Sanyuan Tang, Xiaojing Dong, Peng Xie   +7 more
wiley   +1 more source

Insulin signaling inhibits the 5-HT_2C receptor in choroid plexus via MAP kinase

BMC Neuroscience, 2003
Background G protein-coupled receptors (GPCRs) interact with heterotrimeric GTP-binding proteins (G proteins) to modulate acute changes in intracellular messenger levels and ion channel activity.
Guan Kunliang, DePaoli-Roach Anna A, Marshall Mark S, Bye Leighan S, Zhang Shengwen, Hurley Joyce H, Fox Aaron P, Yu Lei   +7 more
doaj   +1 more source