Results 71 to 80 of about 11,723 (175)

G PROTEIN–COUPLED RECEPTOR KINASES

, 1998
G protein–coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein–coupled receptors (GPCRs) as their primary substrates.
Robert J. Lefkowitz, Julie A. Pitcher, Neil J. Freedman   +2 more
core   +1 more source

The alpha subunit of Go modulates cell proliferation and differentiation through interactions with Necdin [PDF]

, 2014
BACKGROUND: Heterotrimeric GTP-binding proteins (G-proteins) play an important role in mediating signal transduction generated by neurotransmitters or hormones.
Ghil, S, Hyunhee Ju, Sujin Lee, Sunghak Kang, Ju, H, Sung-Soo Kim, Kang, S, Kim, SS, Sungho Ghil, Lee, S   +9 more
core   +1 more source

Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα_(13) Deficiency

, 1997
Heterotrimeric GTP-binding proteins (G proteins) participate in cellular signaling and regulate a variety of physiological processes. Disruption of the gene encoding the G protein subunit α_(13) (Gα_(13)) in mice impaired the ability of endothelial cells
Offermanns, Stefan, Simon, Melvin I., Revel, Jean-Paul, Mancino, Valeria   +3 more
core  

Equibiaxial strain and strain rate stimulate early activation of G proteins in cardiac fibroblasts

, 1998
Cardiac fibroblasts are responsible for the production of the extracellular matrix of the heart, with alterations of fibroblast function implicated in myocardial infarction and cardiac hypertrophy.
Ann A. Lee, Siva R. P. Gudi, Craig B. Clark, John A. Frangos   +3 more
core   +1 more source

Immunolocalization of the G protein alpha subunit encoded by the GPA1 gene in Arabidopsis

, 1993
Heterotrimeric GTP binding proteins (G proteins) are important signal transducers in lower eukaryotes and in animal cells. In plants, the occurrence of GTP binding proteins has been reported, but their biological function remains unclear.
Weiss, C. A., Huang, H., Ma, H.
core   +1 more source

Structural basis for the specific inhibition of heterotrimeric G _q protein by a small molecule

, 2010
Heterotrimeric GTP-binding proteins (G proteins) transmit extracellular stimuli perceived by G protein-coupled receptors (GPCRs) to intracellular signaling cascades. Hundreds of GPCRs exist in humans and are the targets of a large percentage
Masatoshi Taniguchi, Jun Takasaki, Kenji Tago, Akiyuki Nishimura, Norikazu Mizuno, Hiroshi Itoh, Toshio Hakoshima, Ken Kitano   +7 more
core   +1 more source

The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

International Journal of Biological Sciences, 2005
The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane domain (7TM) cell-surface receptors.
doaj  

G-protein regulation of capacitative calcium entry may be mediated by protein kinases A and C in Xenopus oocytes

Inositol 2,4,5-trisphosphate irreversibly activated capacitative calcium entry in Xenopus oocytes, whereas guanosine thiotriphosphate (GTP[S]) and AIF4- only activated capacitative calcium entry transiently.
Berridge, M. J., Petersen, C. C.
core   +1 more source

Ion channel regulation by G proteins

, 1995
Ion channels are poised uniquely to initiate, mediate, or regulate such distinct cellular activities as action potential propagation, secretion, and gene transcription.
K. Wickman, D. E. Clapham
core   +1 more source

A Region Containing a Proline-Rich Motif Targets sGi2 to the Golgi Apparatus

, 2000
International audienceThe central function of heterotrimeric GTP-binding proteins (G proteins) is the transduction of extracellular signals, via membrane receptors, leading to the activation of intracellular effectors.
Borrelli, Emiliana, Picetti, Roberto
core   +1 more source