Results 61 to 70 of about 2,645,999 (191)

Longitudinal Phenotypic Trajectories in GNAO1‐Related Disorders: Defining Disease Progression and Clinical Profiles

Annals of Neurology, Volume 100, Issue 1, Page 154-170, July 2026.
Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral, Ana María Domínguez Cobo, Sol Balsells, Anna Aguilar‐Ros, Chu‐Ting Chang, William G. Ludlam, Kathryn Yang, Katerina Bernardi, Micaela Chinigioli, Ainara Salazar‐Villacorta, Veronica Di Pisa, Nuria Lamagrande‐Casanova, Elena González‐Alguacil, Beatriz De la Casa‐Fages, Akihisa Okumura, Josefina Rodríguez, Ayush Agarwal, Daniela Muñoz‐Chesta, Carolina Reynoso‐Osnayo, Amy Lin, Brahim Tabarki, Jobaida Parvin, Adolfo Alberto Gallo, Andreia Forno, Fabian Maass, Johnny Montiel Blanco, Salomé Nasif, Elizabeth Jennions, Jorge Luis Ramón‐Gómez, Helene Verhelst, Juan José Nieto Barceló, Dunja Čokolić Petrović, Luz Victoria García Ruiz, Christoph van Riesen, Paulo Rego Sousa, Maria del Pilar Massaro Sanchez, Husnea Ara Khan, Wejdan Hakami, Jennifer Friedman, Iván Espinoza‐Quinteros, Monica Troncoso, Divyani Garg, Micaela Pauni, Hirokazu Kurahashi, María Concepción Miranda‐Herrero, Anna Duat‐Rodriguez, Luca Soliani, Manju A. Kurian, Angeles Schteinschnaider, Siddharth Srivastava, Darius Ebrahimi‐Fakhari, Kirill A. Martemyanov, Juan Darío Ortigoza‐Escobar   +52 more
wiley   +1 more source

Splice Type‐Specific Effects of Gαo Subunits on Cerebellar Anatomy and Synapse Formation

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Heterotrimeric Go alpha subunits are widely expressed in the brain to act as molecular switches. In this study we show that Gαo1 and Gαo2 affect cerebellar morphology and synapse formation in an opposite manner. While knockout of Gαo1 results in cerebellar hypoplasia and reduced synaptic input to Purkinje cells by VGLUT2‐positive brainstem climbing ...
Markus Höltje, Anton Wolkowicz, Gudrun Ahnert‐Hilger   +2 more
wiley   +1 more source

Conditional ablation of RGS2 in myeloid cells does not influence blood pressure and organ damage in angiotensin II‐induced hypertension in mice

Physiological Reports, Volume 14, Issue 14, July 2026.
Abstract The role of the immune system in the development of hypertension is well‐established. Recent studies revealed the critical role of G‐protein‐coupled receptor signaling, particularly angiotensin II (Ang II) type 1 receptor (AT1R), in immune cell function.
Pablo Nakagawa, Ko‐Ting Lu, John J. Reho, Mina Ghobrial, Kathren Kaminski, Ana Hantke‐Guixa, Natalia M. Mathieu, Daniel T. Brozoski, Nisita Chaihongsa, Kelsey K. Wackman, Nikhil R. Rajendiran, Zahra Dhoondia, Jeffrey L. Segar, Curt D. Sigmund, Justin L. Grobe   +14 more
wiley   +1 more source

GTP and Ca2+ Modulate the Inositol 1,4,5-Trisphosphate-Dependent Ca2+ Release in Streptolysin O-Permeabilized Bovine Adrenal Chromaffin Cells [PDF]

, 1991
The inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release was studied using streptolysin O-permeabilized bovine adrenal chromaffin cells. The IP3-induced Ca2+ release was followed by Ca2+ reuptake into intracellular compartments.
Föhr, K. J., Ahnert-Hilger, G., Scott, J., Gratzl, Manfred, Stecher, B., M. Gratzl, K. J. Föhr, J. Scott, G. Ahnert-Hilger, B. Stecher   +9 more
core   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 698-710, June 2026.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Ligand-induced dynamics of heterotrimeric G protein-coupled receptor-like kinase complexes.

PLoS ONE, 2017
BackgroundArabidopsis, 7-transmembrane Regulator of G signaling protein 1 (AtRGS1) modulates canonical G protein signaling by promoting the inactive state of heterotrimeric G protein complex on the plasma membrane.
Meral Tunc-Ozdemir, Alan M Jones
doaj   +1 more source

Comprehensive Characterization of ^SGTP-Binding Proteins by Orthogonal Quantitative ^SGTP-Affinity Profiling and ^SGTP/GTP Competition Assays

, 2015
Thiopurine drugs are widely used as antileukemic drugs and immunosuppressive agents, and 6-thioguanosine triphosphate (SGTP) is a major metabolite for these drugs.
Lei Guo (36221), Yongsheng Xiao (1317882), Debin Ji (604255), Yinsheng Wang (8699)   +3 more
core   +2 more sources

Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]

, 2000
The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner, Faussner, Alexander, Adelbert A. Roscher, Roscher, Adelbert A.   +3 more
core   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, Volume 2, Issue 3, Page 280-298, June 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation

Journal of Neuroinflammation, 2012
Background WNT-5A signaling in the central nervous system is important for morphogenesis, neurogenesis and establishment of functional connectivity; the source of WNT-5A and its importance for cellular communication in the adult brain, however, are ...
Halleskog Carina, Dijksterhuis Jacomijn, Kilander Michaela Brita, Becerril-Ortega Javier, Villaescusa Juan, Lindgren Eva, Arenas Ernest, Schulte Gunnar   +7 more
doaj   +1 more source